Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells

Nadalutti, Cristina A.; Prasad, Rajendra; Wilson, S.H.

doi:10.1016/j.dnarep.2021.103134

Cited by 14 publications

(13 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8,9 Formaldehyde (FA), a ubiquitous environmental contaminant, has been reported to be associated with various diseases, such as neurological, dermal, and respiratory disorders as well as cancer. 10,11 As for the association with semen quality, numerous animal studies have found that FA exposure contributes to damage on seminiferous tubules [12][13][14][15][16][17] and declines in semen quality [18][19][20] in rats and mice. Unfortunately, human studies remained limited, and findings have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

Wang

Yang

et al. 2022

JAMA Netw Open

View full text Add to dashboard Cite

IMPORTANCEThe potential effects of long-term occupational exposure to formaldehyde (FA) on human semen quality is not clear. OBJECTIVE To assess whether long-term occupational exposure to FA is associated with semen quality. DESIGN, SETTING, AND PARTICIPANTS This population-based cohort study was conducted fromJune 1 to June 30, 2021, in Xi'an, China. Participants were adults aged 23 to 40 years who had lived in the study area for 24 months or longer. Data analysis was performed from September 1 to October 1, 2021.EXPOSURES Long-term occupational exposure to FA was measured using a formaldehyde detector, and the FA exposure index (FEI) was calculated as follows: FEI = final concentration of FA (mg/m 3 ) × work time during a workday (hour) × cumulative workdays (year). MAIN OUTCOMES AND MEASURESSemen samples were collected by masturbation after 3 to 7 days of abstinence and were then assessed by the computer-automated semen analysis system, Baso-Papanicolaou staining, and sperm-chromatin structure assay. RESULTSA total of 205 men (mean [SD] age, 29.49 [3.64] years), with 124 individuals in the FA exposure group (mean [SD] FEI , 73.72 [54.86]) and 81 age-matched controls, were included in the final analysis. Long-term personal occupational exposure to FA was significantly associated with poor semen quality. Specifically, a 1-unit increase in FEI was associated with a change of −0.

show abstract

Section: Introductionmentioning

confidence: 99%

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

Wang

Yang

et al. 2022

JAMA Netw Open

View full text Add to dashboard Cite

show abstract

“…The combined loss of FANCD2 (a key protein in this pathway) and ALDH2 (which detoxifies endogenous aldehydes) results in loss of HSC-H2AX (a marker of DNA damage) and high genomic instability (Jung & Smogorzewska, 2021). Formaldehyde imbalances have been linked to many diseases including cancer and neurodegenerative diseases (Nadalutti, Prasad, & Wilson, 2021). Formaldehyde monitoring in living things can lead to biochemical findings of pathological conditions characterized by elevated formaldehyde levels such as cancer levels and neurodegenerative disorders (Lipskerov, Sheshukova, & Komarova, 2022).…”

Section: Levels Of Formaldehyde Vs Colony Bacteriamentioning

confidence: 99%

Neutralize Bacterial Activity With Anatomical Embalming Solutions

Aditya

Wicaksono²,

Afandi³

et al. 2022

Jurnal Riset Kesehatan

View full text Add to dashboard Cite

Formaldehyde had some degree of toxicity in the human body as a cadaver preservation solution. Recent studies showed that moderate formaldehyde levels in cadavers could neutralize SARS-CoV-2. However, other effects of formaldehyde levels in the air are not yet known on bacteria. This study aims to determine the optimal level of formaldehyde that can be used to neutralize bacteria and is safe for humans. This study used a post-test control group design with formaldehyde level as the independent variable and bacterial colonization as the dependent variable. The results showed that the mean levels of formaldehyde with the bacterial colony respectively were P1 (1.378±0.716; 0.40±0.10), P2 (0.347±0.038; 1.40±0.10), P3 (0.137±0.006; 2.40 ±0.10), P4 (0.042±0.005; 3.32±0.09), and P5 (0.009±0016; 4.40±0.10). The statistical analysis results revealed a value of p0.05, which indicated that the higher the formaldehyde level, the higher the ability to neutralize bacterial activity. The study concluded the optimum level for neutralizing bacterial activity safe for humans is about 0347±0038 mg/m3.

show abstract

“…Formaldehyde (FA), as the product of one-carbon cycle, folic acid metabolism, creatinine metabolism, epinephrine metabolism, DNA demethylation, and other biological metabolic processes, is a highly toxic RCS in carbonyl stress. Both MDA and FA possess high reactivity and toxicity. , Moreover, as lipid-soluble small molecules, they could easily cross the blood–brain barrier (BBB) and induce protein dysfunction or cross-linking, which are widely involved in the pathogeny of various brain diseases. , Do FA and MDA coordinately regulate the physiological and pathological processes of the brain? To solve the aforementioned issue, powerful identification and sensing tools are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

“…Both MDA and FA possess high reactivity and toxicity. 12,13 Moreover, as lipid-soluble small molecules, they could easily cross the blood−brain barrier (BBB) 14 and induce protein dysfunction or cross-linking, 15 which are widely involved in the pathogeny of various brain diseases. 16,17 Do FA and MDA coordinately regulate the physiological and pathological processes of the brain?…”

Section: ■ Introductionmentioning

confidence: 99%

Janus-Faced Fluorescence Imaging Agent for Malondialdehyde and Formaldehyde in Brains

Wang

Liu

et al. 2022

Anal. Chem.

View full text Add to dashboard Cite

Carbonyl stress caused by reactive carbonyl species (RCS) is closely related to various brain diseases. As the highly reactive, highly toxic, and lipophilic RCS, malondialdehyde (MDA) and formaldehyde (FA) could easily cross the blood–brain barrier (BBB) and induce protein dysfunction or cross-linking in the brain. Do MDA and FA coordinately regulate the physio-pathological processes of the brain? To answer the question, first of all, powerful identification and sensing tools are needed. However, competent probes for simultaneously analyzing MDA and FA in living brains are lacking, which originates from the following three challenges: (1) MDA and FA are difficult to distinguish due to their great similarity in structure and reactivity; (2) to achieve simultaneous and discriminable imaging, same excitation and different emissions are preferable; and (3) the detection of MDA and FA in living brains require the materials to pass through the BBB. Thus, we created a two-photon fluorescent agent, TFCH, for MDA/FA. The hydrazine group in TFCH could successfully differentiate MDA/FA at 440/510 nm under same excitation. Moreover, the lipophilic trifluoromethyl group (−CF3) in TFCH prompts it to traverse the BBB, thereby realizing the coinstantaneous visualization of MDA and FA in the living brain. Using TFCH, we observed the excessive production of MDA and FA in living PC12 cells under carbonyl stress and oxidative stress. Notably, for the first time, two-photon fluorescence imaging indicated the synchronous increase of MDA and FA in living brains of mice with depression. Altogether, this work provides a promising tool for revealing the carbonyl stress-related molecular mechanism involved in brain diseases.

show abstract

Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells

Cited by 14 publications

References 93 publications

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

Neutralize Bacterial Activity With Anatomical Embalming Solutions

Janus-Faced Fluorescence Imaging Agent for Malondialdehyde and Formaldehyde in Brains

Contact Info

Product

Resources

About