“…This is attributed to their unique nanostructural versatility, the biocompatibility of their major lipid constituents (such as monounsaturated monoglycerides, diunsaturated monoglycerides, and omega-3 fatty acid monoglycerides), bioadhesive properties, and capability of loading and sustaining the release of amphiphilic, hydrophobic, and hydrophilic drugs [ 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 ]. Further, it is worth exploring the possible functionalization of hydrogels or polymeric matrices by embedding the corresponding nanoparticles of the inverse non-lamellar lyotropic liquid crystalline phases (particularly cubosomes and hexosomes), which are recently popular nano-self-assemblies in the development of nanocarriers for drug delivery applications [ 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 ], or through their immobilization for designing cubosome or hexosome coatings by employing chemical surface activation methods. The latter strategy is typically applied for immobilization of lamellar liquid crystalline nanoparticles (liposomes) and various soft and hard nanoparticles (such as silver nanoparticles) [ 49 , 70 , 72 , 105 ].…”