Perspectives on antifungal susceptibility testing in Candida

Deorukhkar, Sachin Chandrakant; Saini, Santosh; Mathew, Stephen

doi:10.14194/ijitd.1.2.1

Cited by 3 publications

(4 citation statements)

References 43 publications

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“…Finally, the formed nystatin can combine with the produced Bi 0 (eqn (6)) though the oxygen atoms in the OH functional groups of the nystatin molecules to form more permanent Bi 2 O 3 NPs, as displayed in eqn (7).…”

Section: Proposal Reaction Mechanism For Bi 2 O 3 Nps Synthesismentioning

confidence: 99%

“…6 There are some determinants willing to enhancing the virulence of Candida species such as the expanded usage of complete parenteral diet, intravenous catheters, broad-spectrum antibiotics, and cytotoxic chemotherapy. 7 Tremendous progress in fungal diagnostics and antifungal medication has been made in the past 25 years; however, this has not been reected in signicant changes in antifungal production. 8 The emergence of C. albicans has highlighted some real challenges because several species present different levels of resistance (acquired or natural), creating difficulties for the generally applied antifungal drugs to work effectively.…”

Section: Introductionmentioning

confidence: 99%

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Nystatin-mediated bismuth oxide nano-drug synthesis using gamma rays for increasing the antimicrobial and antibiofilm activities against some pathogenic bacteria andCandidaspecies

et al. 2020

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Section: Proposal Reaction Mechanism For Bi 2 O 3 Nps Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nystatin-mediated bismuth oxide nano-drug synthesis using gamma rays for increasing the antimicrobial and antibiofilm activities against some pathogenic bacteria andCandidaspecies

et al. 2020

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“…Members of the genus Candida has been earlier recognized as commensal and normal microbiota of human. Recent findings have shown that these organisms are now resistant to many antifungal and also possess different pathogenic factors (Deorukhkar et al, 2014). They have been reported to be associated with different mycotic infections especially among the immunocompromised, severely ill patients and also immunocompetent individuals (Pfaller and Diekema, 2007).…”

Section: Introductionmentioning

confidence: 99%

Detection of virulence factors and antifungal resistant patterns of Candida species isolated from women with urinary tract infections

David¹,

Adeola²,

Faloye³

et al. 2022

Bayero J. Pure App. Sci.

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The incidence of Candida species has increased among females of child bearing age over the years. There has also been an increase in the resistance of these Candida species to the antifungal drugs used to treat them. This study is aimed at detecting the prevalence of Candida species among patients with urinary tract infections (UTI) attending gynecological unit of Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria. The distribution of pathogenic factors and the antifungal resistance pattern of the isolates were also determined. A total of 61 subjects of different ages and socioeconomic status attending the health facility were enrolled in this study. Samples of high vaginal swab (HVS) were collected from each of the participant and screened. A total of 36 candidal isolates were recovered from the samples out of which 11 (30.5%) were predominantly Candida albican, 5 (13.9%) Candida krusei, 4 (11.1%) Candida glabrata, 2 (5.6%) Candida tropicalis and 14 (38.9%) were not identified beyond the genus level. Ten (27.8%) of the isolates were not able to produce biofilm. Out of those that produce biofilm 17 (47.2%) produced weak biofilm, 5 (8.2%) produced moderate biofilm, while 4 (11.1%) produced strong biofilm. Spectrophotometer was used to quantify those that produce biofilm 9 (25%) produced moderate biofilm while 16 (44.4%) produced strong biofilm. The isolates were subjected to various pathogenicity tests which include haemolysis, catalase, phospholipase and hydrolysis. This test shows that Candida species has the highest percentage to the entire test while none of C. glabrata produced haemolysin and phospholipase. Antifungal assay was then carried out on the entire organisms showed Candida albicans to have low resistance to the azoles drugs while the non-albican Candida shows higher resistance to it. Extremely high prevalence of Candida albicans and Candida species were documented in this study. These findings should be taken into account in further research concerning presence of Candida among patient with sexually transmitted disease in Nigeria.

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“…14 Candida has emerged as important species associated with opportunistic infections, resulting in a significant public health issue. 15 Several predisposing factors including immunodeficiency, antineoplastic therapy, organ transplantation, endocrine dysfunction, and prolonged antibiotic use increase susceptibility to Candida infection. 16 Candida spp.…”

Section: Introductionmentioning

confidence: 99%

Profiling the Cymbopogon nardus Ethanol Extract and Its Antifungal Potential against Candida Species with Different Patterns of Resistance

Toledo¹,

Ramos²,

Spósito³

et al. 2020

J. Braz. Chem. Soc.

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The essential oil of Cymbopogon nardus, citronella, has been extensively studied. However, the chemical and biological properties of the ethanolic extract (EE) of C. nardus have not been evaluated. The aim of this study was to characterize the chemical composition of the EE of C. nardus and its active fraction (FrD). Moreover, the cytotoxic and antifungal properties of these extracts against Candida species with different resistance profiles to conventional drugs were evaluated. The compounds identified in EE were mono-C-and di-C-glycosyl flavones and phenylpropanoid glycosides. Phenylpropanoid glycosides were identified in FrD. EE showed antifungal activity, with minimum inhibitory concentration (MIC) values ranging from 62.5 to 500 µg mL -1 . FrD was more effective against C. glabrata, as evidenced by the lowest MIC value (15.6 µg mL -1 ). EE inhibited yeast growth similar to amphotericin-B, as demonstrated by similar time-kill curves. EE inhibited C. albicans hyphae formation and mature biofilm of C. albicans, C. krusei and C. parapsilosis. The results of the chemical and biological analyses of EE and its fractions provided novel information and may contribute to control of infections caused by Candida species.

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Perspectives on antifungal susceptibility testing in Candida

Cited by 3 publications

References 43 publications

Nystatin-mediated bismuth oxide nano-drug synthesis using gamma rays for increasing the antimicrobial and antibiofilm activities against some pathogenic bacteria andCandidaspecies

Nystatin-mediated bismuth oxide nano-drug synthesis using gamma rays for increasing the antimicrobial and antibiofilm activities against some pathogenic bacteria andCandidaspecies

Detection of virulence factors and antifungal resistant patterns of Candida species isolated from women with urinary tract infections

Profiling the Cymbopogon nardus Ethanol Extract and Its Antifungal Potential against Candida Species with Different Patterns of Resistance

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