Perspectives of Immune Therapy in Coronavirus Disease 2019

Gasparyan, Armen Yuri; Misra, Durga Prasanna; Yessirkepov, Marlen; Zimba, Olena

doi:10.3346/jkms.2020.35.e176

Cited by 58 publications

(62 citation statements)

References 39 publications

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“…The coronavirus disease 2019 (COVID-19) pandemic and consequent need for boosting immunity and following hygiene and social distancing regulations to mitigate infection risks have led researchers, clinicians and journal editors around the world to search for rational hypotheses, ideas, and emerging evidence for prevention and management of this new disease. 1,2 While established scholarly platforms continue publishing and disseminating peer-reviewed and validated items on the new coronavirus, numerous online channels with variable quality checks are emerging and supplying their users with statements, instructions, and recommendations on various aspects of COVID-19. 3 The scarcity of highly skilled professionals, primarily physicians with diverse interests in virology, immunology and thrombology, capable of moderating the unprecedented flow of information via the established and alternative communication channels paves the way for circulation of poorly checked and misleading hypotheses, ideas, and research outcomes.…”

Section: Introductionmentioning

confidence: 99%

Information and Misinformation on COVID-19: a Cross-Sectional Survey Study

et al. 2020

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Background: The coronavirus disease 2019 (COVID-19) pandemic has led to a large volume of publications, a barrage of non-reviewed preprints on various professional repositories and a slew of retractions in a short amount of time. Methods: We conducted an e-survey using a cloud-based website to gauge the potential sources of trustworthy information and misinformation and analyzed researchers', clinicians', and academics' attitude toward unpublished items, and pre-and post-publication quality checks in this challenging time. Results: Among 128 respondents (mean age, 43.2 years; M:F, 1.1:1), 60 (46.9%) were scholarly journal editors and editorial board members. Social media channels were distinguished as the most important sources of information as well as misinformation (81 [63.3%] and 86 [67.2%]). Nearly two in five (62, 48.4%) respondents blamed reviewers, editors, and misinterpretation by readers as additional contributors alongside authors for misinformation. A higher risk of plagiarism was perceived by the majority (70, 58.6%), especially plagiarism of ideas (64.1%) followed by inappropriate paraphrasing (54.7%). Opinion was divided on the utility of preprints for changing practice and changing retraction rates during the pandemic period, and higher rejections were not supported by most (76.6%) while the importance of peer review was agreed upon by a majority (80, 62.5%). More stringent screening by journal editors (61.7%), and facilitating open access plagiarism software (59.4%), including Artificial Intelligence (AI)-based algorithms (43.8%) were among the suggested solutions. Most (74.2%) supported the need to launch a specialist bibliographic database for COVID-19, with information indexed (62.3%), available as open-access (82.8%), after expanding search terms (52.3%) and following due verification by academics (66.4%), and journal editors (52.3%). Conclusion: While identifying social media as a potential source of misinformation on COVID-19, and a perceived high risk of plagiarism, more stringent peer review and skilled post-publication promotion are advisable. Journal editors should play a more active role in streamlining publication and promotion of trustworthy information on COVID-19.

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Section: Introductionmentioning

confidence: 99%

Information and Misinformation on COVID-19: a Cross-Sectional Survey Study

et al. 2020

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“…Rheumatologists and immunologists have substantial expertise in the pathogenesis of the immune response, the impact of inflammation, and their treatments [1][2][3][4]. Several immunomodulatory and antiinflammatory drugs (e.g., hydroxychloroquine, colchicine, tocilizumab, anakinra) have been used for COVID-19 when scientists are in search of a possible treatment for this novel virus and a resultant inflammatory response [1][2][3][4][6][7][8]. Since rheumatologists have substantial knowledge in the benefits and adverse effects of these drugs as well, rheumatologists are playing a significant role in this pandemic.…”

Section: Introductionmentioning

confidence: 99%

Public interest in rheumatic diseases and rheumatologist in the United States during the COVID-19 pandemic: evidence from Google Trends

et al. 2020

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To evaluate the public interest in rheumatic diseases during the coronavirus disease 2019 (COVID-19) pandemic. Google Trends was queried to analyze search trends in the United States for numerous rheumatic diseases and also the interest in a rheumatologist. Three 8-week periods in 2020 ((March 15-May 9), (May 10-July 4), and (July 5-August 29)) were compared to similar periods of the prior 4 years (2016-2019). Compared to a similar time period between 2016 and 2019, a significant decrease was found in the relative search volume for more than half of the search terms during the initial March 15-May 9, 2020 period. However, this trend appeared to reverse during the July 5-August 29, 2020 period where the relative volume for nearly half of the search terms were not statistically significant compared to similar periods of the prior 4 years. In addition, this period showed a significant increase in relative volume for the terms: Axial spondyloarthritis, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, Sjögren's syndrome, antiphospholipid syndrome, scleroderma, Kawasaki disease, Anti-Neutrophil Cytoplasmic Antibody (ANCA)-associated vasculitis, and rheumatologist. There was a significant decrease in relative search volume for many rheumatic diseases between March 15 and May 9, 2020 when compared to similar periods during the prior 4 years. However, the trends reversed after the initial period ended. There was an increase in relative search for the term "rheumatologist" between July and August 2020 suggesting the need for rheumatologists during the COVID-19 pandemic. Policymakers and healthcare providers should address the informational demands on rheumatic diseases and needs for rheumatologists by the general public during pandemics like COVID-19.

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“…According to the Guidance for healthcare professionals on coronavirus (COVID-19) infection in pregnancy, published by the RCOG and Royal College of Midwives, pregnant women do not appear to be more susceptible to coronavirus infection than the rest of the population [6]. However, the immune's system response to viral infection during pregnancy makes these women vulnerable to COVID-19 and can cause more severe symptoms [6,33]. Most of the pregnant women experience flu-like symptoms with a cough, shortness of breath, fever, anosmia, headache, and diarrhea [6,23,27].…”

Section: Clinical Features Of Covid-19 In a Pregnant Womanmentioning

confidence: 99%

Coronavirus disease 2019 (COVID-19) during pregnancy in patients with rheumatic diseases

2020

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The novel coronavirus outbreak induces many concerns about the management of pregnancy, as well as rheumatic and musculoskeletal diseases. The very rapid spread of the infection throughout all inhabited continents leads to a fast-growing number of infected with SARS-CoV-2 and requires answers and special recommendations to the most vulnerable group of people: pregnant woman and patients on immunomodulatory or immunosuppressive treatment. A systematic literature search was performed in Embase, MEDLINE, and Scopus database for studies describing COVID-19 infection in pregnant women diagnosed with rheumatic and musculoskeletal diseases. From the 1,115 initially identified articles, we selected 29 publications in the English language, from which 18 were eligible according to the inclusion criteria. Limited number of cases and further researches are required to evaluate the risk of transmission of SARS-CoV-2 from mother to her infant as well as clinical features of infection in pregnant women. The conclusions of different authors, despite the small number of cases, suggest that there is no vertical transmission in women diagnosed with COVID-19 pneumonia. Although the World Health Organization recently reported that pregnant patients do not have a higher risk of infection than the rest of the population, Royal College of Obstetricians & Gynecologists and The Royal College of Midwives for COVID-19 infection in pregnancy published Guidelines for pregnant women with suspected SARS-CoV-2 infection. Considerations about patients with rheumatic diseases on the immunosuppressive treatment required European League Against Rheumatism, American College of Rheumatology, British Society for Rheumatology, and Australian Rheumatology Association to publish recommendations for patients with rheumatic diseases and COVID-19. These algorithms are very important to the medical society, but many concerns, absence of experience, and many questions are still unanswered and need time to be resolved and proceed successfully in this global pandemic situation.

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Perspectives of Immune Therapy in Coronavirus Disease 2019

Cited by 58 publications

References 39 publications

Information and Misinformation on COVID-19: a Cross-Sectional Survey Study

Information and Misinformation on COVID-19: a Cross-Sectional Survey Study

Public interest in rheumatic diseases and rheumatologist in the United States during the COVID-19 pandemic: evidence from Google Trends

Coronavirus disease 2019 (COVID-19) during pregnancy in patients with rheumatic diseases

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