Perspectives of gene editing for cattle farming in tropical and subtropical regions

Camargo, L. S. A.; Saraiva, Naiara Zoccal; Oliveira, C. S.; Carmickle, Allie T; Lemos, D.R.; Siqueira, L. G. B.; Denicol, Anna C.

doi:10.1590/1984-3143-ar2022-0108

Cited by 4 publications

(2 citation statements)

References 109 publications

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“…Numerous comprehensive reviews have been published on the topic of gene-editing technology and gene-edited (GE) animal models, including those by Roth and Tuggle (2015) , Kalds et al (2019 , 2020 ), McFarlane et al (2019) , Lee et al (2020) , Menchaca et al (2020) , Navarro-Serna et al (2020) , Maynard et al (2021) , Perisse et al (2021) , Hay et al (2022) , Lin et al (2022) and Camargo et al (2023) . In this article, we aim to provide an overview of key developments and recent advancements in the CRISPR/Cas9 field, along with a review of relevant literature focused on the generation of edited cell lines and animals ( Figure 1 ) with specific biomedical and veterinary applications, building upon the existing literature.…”

Section: Gene Editingmentioning

confidence: 99%

Gene editing in small and large animals for translational medicine: a review

Mariano Junior,

Oliveira,

Ambrósio

2024

Anim. Reprod.

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The CRISPR/Cas9 system is a simpler and more versatile method compared to other engineered nucleases such as Zinc Finger Nucleases (ZFNs) and Transcription Activator-Like Effector Nucleases (TALENs), and since its discovery, the efficiency of CRISPR-based genome editing has increased to the point that multiple and different types of edits can be made simultaneously. These advances in gene editing have revolutionized biotechnology by enabling precise genome editing with greater simplicity and efficacy than ever before. This tool has been successfully applied to a wide range of animal species, including cattle, pigs, dogs, and other small animals. Engineered nucleases cut the genome at specific target positions, triggering the cell's mechanisms to repair the damage and introduce a mutation to a specific genomic site. This review discusses novel genome-based CRISPR/Cas9 editing tools, methods developed to improve efficiency and specificity, the use of gene-editing on animal models and translational medicine, and the main challenges and limitations of CRISPR-based gene-editing approaches.

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Section: Gene Editingmentioning

confidence: 99%

Gene editing in small and large animals for translational medicine: a review

Mariano Junior,

Oliveira,

Ambrósio

2024

Anim. Reprod.

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“…SCCs collected from Angus are isolated and expanded in vitro and then transplanted into the seminiferous tubules of NANOS2-null surrogate Nelore male. Beef farmers in the tropics can use surrogate Nelore sires to breed Nelore cows in order to produce Angus x Nelore F1 calves (Camargo et al 2022) Page 7 of 28 Hallerman et al CABI Agriculture and Bioscience (2024) 5:25 Poultry production in Africa is based upon a limited number of breeds, and within-breed genetic diversity is declining. Genetic variation is the basis for breeding to increase productivity and resistance to diseases and heat stress.…”

Section: Animal Biotechnology and International Developmentmentioning

confidence: 99%

Enabling regulatory policy globally will promote realization of the potential of animal biotechnology

Hallerman,

Bredlau,

Camargo

et al. 2024

CABI Agric Biosci

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Animal biotechnologies have the potential to improve the sustainability and security of our global food systems. Government regulatory authorities are responsible for ensuring the safety of food their citizens consume, whether it is produced via conventional breeding methods or biotechnologies. While some countries have implemented animal biotechnology oversight policies, many countries have yet to develop theirs. Historically, regulatory approvals were required before products of biotechnology could enter the marketplace, and the high cost of the approval process limited the number and types of animal and plant products that sought approval. Only one biotech animal in the world that was developed for food production has reached the market under a GMO or rDNA approval process. The advent of genome editing techniques has revolutionized the scientific approach to introducing changes into DNA sequences and how biotechnology can be used to enhance agricultural breeding. Regulatory dialogs about biotechnology also have changed as a result of these new technologies. Regulatory agencies have begun to respond to these scientific advances, and a growing number of countries are looking to modernize regulatory approaches for these products, based on risk (or lack thereof) and similarity to organisms that could be produced via conventional breeding methods. Advances in animal biotechnology, especially genome editing, can accelerate the incorporation of valued phenotypes in animals, including enhanced yield, disease resistance, resilience to changing climate, and improved animal welfare, as well as food qualities valued by consumers. For animals with these biotechnology-introduced traits to enter agricultural production and reach consumers, clear risk-proportionate regulatory approaches must be in place, and to facilitate international trade of animal products, regulatory processes need to be aligned and compatible. Effective scientific public communication is crucial to build public trust in precision animal biotechnology and risk-proportionate regulatory approaches. An international workshop on regulatory approaches for animal biotechnology was convened in 2022 with 27 countries represented. We synthesize here technical progress, development of regulatory policy, and strategies for engagement with diverse publics on animal biotechnology reported in the workshop. Our goal is to encourage development and implementation of risk-proportionate regulatory approaches and policies in a global context.

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Editing microbes to mitigate enteric methane emissions in livestock

Khan,

Ali,

et al. 2024

World J Microbiol Biotechnol

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Perspectives of gene editing for cattle farming in tropical and subtropical regions

Cited by 4 publications

References 109 publications

Gene editing in small and large animals for translational medicine: a review

Gene editing in small and large animals for translational medicine: a review

Enabling regulatory policy globally will promote realization of the potential of animal biotechnology

Editing microbes to mitigate enteric methane emissions in livestock

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