Perspectives in the control of infectious diseases by transgenic mosquitoes in the post-genomic era: a review

Sperança, Márcia Aparecida; Capurro, Margareth Lara

doi:10.1590/s0074-02762007005000054

Cited by 42 publications

(35 citation statements)

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“…Research efforts have been made in this direction, mainly from the perspective of genetic modifications in the vector, development of traps capable of suppressing winged forms 52,60,61,62,63 , and the incorporation of new pedagogical practices favoring population behavior changes in relation to reduction in the availability of Ae. aegypti breeding sites.…”

Section: Limits and Challenges For Dengue Controlmentioning

confidence: 99%

Dengue: twenty-five years since reemergence in Brazil

et al. 2009

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Section: Limits and Challenges For Dengue Controlmentioning

confidence: 99%

Dengue: twenty-five years since reemergence in Brazil

et al. 2009

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“…The vector control, mainly by insecticide application and elimination of oviposition sites, has been used as the best solution to decrease the diseases incidence. Explore new strategies for blocking the insect transmitted diseases such as dengue fever is urgent in Tropical countries (Sperança & Capurro 2007). Microorganisms associated with the insect may have an important role for human infectious diseases epidemiology.…”

mentioning

confidence: 99%

First isolation of microorganisms from the gut diverticulum of Aedes aegypti (Diptera: Culicidae): new perspectives for an insect-bacteria association

Gusmão

Santos

Marini

et al. 2007

Mem. Inst. Oswaldo Cruz

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We show for the first time that the ventral diverticulum of the mosquito gut (impermeable sugar storage organ) harbors microorganisms. The gut diverticulum from newly emerged and non-fedAedes aegypti (Diptera: Culicidae, Aedini) is the main urban vector for the human diseases yellow fever and dengue fever (Nasci & Miller 1996). The vector control, mainly by insecticide application and elimination of oviposition sites, has been used as the best solution to decrease the diseases incidence. Explore new strategies for blocking the insect transmitted diseases such as dengue fever is urgent in Tropical countries (Sperança & Capurro 2007). Microorganisms associated with the insect may have an important role for human infectious diseases epidemiology. Once a key role bacterium is discovered, it may be modified in order to affect the pathogen development and, consequently, the disease transmission (Azambuja et al. 2005, Riehle & Jacobs-Lorena 2005.The alimentary canal of the mosquito is composed by the foregut, midgut and hindgut. The foregut is involved primarily with ingestion, conduction and storage of food (Romoser 1996). In the alimentary canal of the mosquito three diverticula arise near the posterior end of the esophagus: two from the dorso-lateral and one from the ventral wall of the gut, all surrounded by a thin impermeable cuticle. The ventral diverticulum (VD), or crop, is large and may extend into the abdomen (Dapples & Lea 1974). Usually all three diverticula are filled with air bubbles and are used as food reservoirs (Thompson 1905, Consoli & Lourenço-de-Oliveira 1994. The sugar meal, such as floral nectar, is stored in the diverticula and passes slowly to the midgut, where it is digested (Thompson 1905).Microorganisms play important and often essential roles in the growth and development of many insect species. Despite the importance of these microbial associations with insects there are relatively few studies that elucidate their components and their roles in the interactions. Insects that rely on nutritionally poor diets tend to possess bacterial endosymbionts. Aphids, for example, which subsist solely on plant sap, harbor Buchnera spp., believed to provide amino acids and vitamins to their hosts (Douglas 1989). Blood is known to be severely deficient in essential B vitamins and some amino acids. Bloodsucking arthropods such as ticks, lice, bedbugs, reduviid bugs, and tsetse flies usually harbor symbiotic microorganisms (Buchner 1965). Symbiotic relationships have already been reported for blood feeding insects and some are very well established, as in the case of Rhodnius prolixus that maintains an association with the actinomycete bacteria Rhodococcus rhodnii (Dasch et al. 1984); and tsetse flies genus Glossina, which harbor three distinct symbiotic microorganisms: Wigglesworthia glossinidia, Sodalis glossinidius (commensal), and the parasitic microbe Wolbachia pipientis (Aksoy et al. 1997, Chen et al. 1999.Many key questions about bacteria within the mosquito's midgut remain largely unanswered, and ob...

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“…aegypti were Hermes [1] from housefly Musca domestica, mariner element Mos1 [2] from D. mauritiana, piggyback (pBac) [3] from Trichoplusiani, and minos from D. hydei. The vector transformation could also be done with the help of endosymbionts such as intracellular symbiotic bacterium Wolbachia [4]. Genetically modified Wolbachia could be used to transduce mosquitoes with parasite transmission blocking genes.…”

Section: Mini-reviewmentioning

confidence: 99%

“…aegypti in the past. Since the transgene expressions driven by these promoters were very weak, stronger promoters were subsequently used in developing TMs [4]. The strong promoters such as Ae.…”

Section: Mini-reviewmentioning

confidence: 99%

“…TMs as one of the promising control strategies, the mosquito having a foreign DNA that codes for a synthetic gene, AgCP[SM1] [4] containing CP signal sequence, and coding sequences of four subunits of SM1 under the regulation of AgCP promoter was constructed and inserted into pBac transposable element (TE) containing vector with enhanced green fluorescent protein (EGFP)gene under the regulation of mosquito eye specific 3xP3 promoter. The final DNA construct was then transformed along with transposase enzyme coding helper plasmid into embryos of An.…”

Section: Mini-reviewmentioning

confidence: 99%

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