Perspectives for the Control of Chronic Pseudomonas aeruginosa Lung Infections of Cystic Fibrosis Patients

Woods, Donald E.

doi:10.1007/978-1-4615-3036-7_19

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…Bacterial binding can be substantially increased by modification of the epithelial surface by acid (14), trypsin (15), influenza infection, trauma (16), or the effect of the accumulated P. aeruginosa exoproducts in culture supernatants (17). The GalNAc31-4Gal sequence present in asialylated gangliosides can function as a receptor for several pathogens of the respiratory tract including P. aeruginosa (18).…”

Section: Introductionmentioning

confidence: 99%

Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression.

Cacalano¹,

Kays²,

Saiman³

et al. 1992

J. Clin. Invest.

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The pathogenesis of Pseudomonas aeruginosa infection in cystic fibrosis (CF) is a complex process attributed to specific characteristics of both the host and the infecting organism. In this study, the properties of the PA0i neuraminidase were examined to determine its potential role in facilitating Pseudomonas colonization of the respiratory epithelium. The PAO1 neuraminidase was 1000-fold more active than the Clostridium

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Section: Introductionmentioning

confidence: 99%

Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression.

Cacalano¹,

Kays²,

Saiman³

et al. 1992

J. Clin. Invest.

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“…Pseudomonas aeruginosa seldom causes uncomplicated UTIs and no specific clinical characteristics differentiate pseudomonas infections from other types of P. VISCA AND OTHERS urinary infections [2]. Their pathogenesis could be related to the production of several cell-associated and extracellular virulence factors including adhesins [6][7][8][9], alginate [10,11], endotoxin [12], exotoxin A [13][14][15][16], exoenzyme S [17][18][19], elastase [20][21][22], alkaline protease [23,24], phospholipase C [25,26] and the two siderophores pyochelin [27,28] and pyoverdin [29,30]. However, a detailed analysis of the virulence determinants in the most frequent epidemiological types of uropathogenic P. aeruginosa strains has not been carried out so far.…”

Section: Introductionmentioning

confidence: 99%

Virulence determinants inPseudomonas aeruginosastrains from urinary tract infections

et al. 1992

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A total of 121 uropathogenic Pseudomonas aeruginosa strains were examined for production of several virulence-related factors. These strains were distributed in five predominant O-serotypes, i.e. O 4, O 12, O 11, O 6 and O 5, which accounted respectively for 23.9, 23.1, 12.3, 8.2 and 5.7% of isolates. Pyochelin and pyoverdin siderophores were produced by most of the isolates, defective variants occurring at very low frequency (2.4% for pyochelin and 7.4% for pyoverdin). Adherence to uroepithelial cells and production of cytotoxins was demonstrated in 52.8 and 67.7% of the strains, respectively, with higher frequencies for epidemiologically related strains belonging to serotypes O 4 and O 12. Titration of total proteases, elastase and phospholipase C revealed a high degree of heterogeneity among isolates. However, examination of individual O-serotypes by exoenzyme production showed that elevated levels of total proteases and elastase were characteristics of serotypes of minor numerical importance, i.e. O 1, O 10, O 11 and O 17, whilst low levels of elastase were produced by strains belonging to the predominant serotypes, namely O 4 and O 12. Moreover, epidemiologically related strains belonging to serotypes O 4 and O 12 appeared more homogeneous than the whole serogroup, when compared with other groups on the basis of exoenzyme levels.

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“…A similar response was described with the inoculation of fragments of the same biofilm bacteria trapped in agar beads and introduced into the lung (Woods et al, 1980).…”

Section: Host Resistance To Biofilmmentioning

confidence: 72%

Biofilms: A Survival and Resistance Mechanism of Microorganisms

Estela¹,

Alejandro²

2012

Antibiotic Resistant Bacteria - A Continuous Challenge in the New Millennium

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Perspectives for the Control of Chronic Pseudomonas aeruginosa Lung Infections of Cystic Fibrosis Patients

Cited by 4 publications

References 29 publications

Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression.

Production of the Pseudomonas aeruginosa neuraminidase is increased under hyperosmolar conditions and is regulated by genes involved in alginate expression.

Virulence determinants inPseudomonas aeruginosastrains from urinary tract infections

Biofilms: A Survival and Resistance Mechanism of Microorganisms

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