2022
DOI: 10.3389/fmolb.2022.777775
|View full text |Cite
|
Sign up to set email alerts
|

Perspectives for Combining Viral Oncolysis With Additional Immunotherapies for the Treatment of Melanoma

Abstract: Melanoma is the deadliest type of skin cancer with steadily increasing incidence worldwide during the last few decades. In addition to its tumor associated antigens (TAAs), melanoma has a high mutation rate compared to other tumors, which promotes the appearance of tumor specific antigens (TSAs) as well as increased lymphocytic infiltration, inviting the use of therapeutic tools that evoke new or restore pre-existing immune responses. Innovative therapeutic proposals, such as immune checkpoint inhibitors (ICIs… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(3 citation statements)
references
References 235 publications
(289 reference statements)
0
3
0
Order By: Relevance
“…Intratumoral administration of the oncolytic poliovirus PVSRIPO, the live attenuated, type I poliovirus (Sabin) vaccine harboring an internal ribosome entry site (IRES) of human rhinovirus type 2, has demonstrated initial promise in patients with recurrent glioblastoma multiforme (NCT03712358) ( 110 ). In contrast, PVSRIPO infects macrophages and DCs in culture, causing the expression of major histocompatibility complex class II (MHC II) and the generation of IFN-b and IL-12 ( 9 , 87 ).…”
Section: Various Types Of Ovsmentioning
confidence: 99%
See 2 more Smart Citations
“…Intratumoral administration of the oncolytic poliovirus PVSRIPO, the live attenuated, type I poliovirus (Sabin) vaccine harboring an internal ribosome entry site (IRES) of human rhinovirus type 2, has demonstrated initial promise in patients with recurrent glioblastoma multiforme (NCT03712358) ( 110 ). In contrast, PVSRIPO infects macrophages and DCs in culture, causing the expression of major histocompatibility complex class II (MHC II) and the generation of IFN-b and IL-12 ( 9 , 87 ).…”
Section: Various Types Of Ovsmentioning
confidence: 99%
“…Currently, oncolytic virotherapy (OVT) is one of the most popular cancer immunotherapy approaches owing to the flexibility of viral production platforms and providing a multimodal strategy to selectively and efficiently target and destroy tumor cells ( 9 , 10 ). Furthermore, OV platforms could be applied without depth knowledge of tumor antigens in various malignancies ( 11 ).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation