Perspectives and strategies of alternative methods used in the risk assessment of personal care products

Quantin, Paul; Thélu, A.; Catoire, Sophie; Ficheux, H.

doi:10.1016/j.pharma.2015.06.002

Cited by 7 publications

(4 citation statements)

References 79 publications

(74 reference statements)

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“…Economic Co-operation and Development (OECD) have developed and adopted many alternative methods to assess the irritation potential of cosmetic ingredients based on cellular responses and molecular pathways leading to adverse endpoints. 13 These assays are rapid, inexpensive, and high-throughput compared to animal models and can be used to investigate the toxicological mechanism of chemicals. 14 In this study, we used the patch test and repeated open application test (ROAT), which are two regulatory methods used to evaluate adverse skin effects of cosmetics in China, to examine the skin irritation potential of five commonly used cosmetic preservatives in the general population, including phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, and DMDM hydantoin.…”

Section: Validation Of Alternative Methods (Ecvam) and Organization Formentioning

confidence: 99%

“…With increasing political and ethical demand to replace animal experiments, many countries have set regulatory requirements to evaluate the safety of cosmetic ingredients using nonanimal test methods, especially in Europe 12 . The European Centre for the Validation of Alternative Methods (ECVAM) and Organization for Economic Co‐operation and Development (OECD) have developed and adopted many alternative methods to assess the irritation potential of cosmetic ingredients based on cellular responses and molecular pathways leading to adverse endpoints 13 . These assays are rapid, inexpensive, and high‐throughput compared to animal models and can be used to investigate the toxicological mechanism of chemicals 14 …”

Section: Introductionmentioning

confidence: 99%

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Skin irritation potential of cosmetic preservatives: An exposure‐relevant study

Wang

Song

et al. 2020

J of Cosmetic Dermatology

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Cosmetic products comprise a variety of nutrient-rich ingredients that favor microbial growth, and the microbial contamination of cosmetics is a health risk for consumers. Preservatives are an essential component to inhibit the development of microorganisms and to prolong the shelf life and usage time of cosmetic products. 1 Unfortunately, preservatives have been reported to cause skin irritation and be a common source of allergies in cosmetic and household products. 2-4 Based on the frequency of use and the prevalence of skin side effects, the prominent preservatives in cosmetics comprise phenoxyethanol, parabens, formaldehyde releasers, isothiazolinones, and organic acids. 5,6 Their health effects are not only due to the induction of skin irritation but also to their multiple sources of exposure resulting in both occupational and nonoccupational contact dermatitis. 7,8 Considering the widespread use of preservatives in daily life, it is a great challenge to evaluate the skin irritation potential of these preservatives and elucidate their underlying mechanisms.

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Section: Validation Of Alternative Methods (Ecvam) and Organization Formentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Skin irritation potential of cosmetic preservatives: An exposure‐relevant study

Wang

Song

et al. 2020

J of Cosmetic Dermatology

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“…In these studies thalidomide was shown to be a low-risk drug regarding intoxication and side effects, however in the 1960s it was responsible for the congenital malformation of thousands of children. Similarly, the Draize test in rabbits for ocular and cutaneous irritation by substances, especially cosmetics, has low reproducibility and highlights concerns about extrapolation of test results in animals to humans (Quantin et al ., 2015). In vivo tests have some advantages and disadvantages.…”

Section: In Vivo Testsmentioning

confidence: 99%

In vitro culture systems as an alternative for female reproductive toxicology studies

Guerreiro

Mbemya

Bruno

et al. 2019

Zygote

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SummaryStudies have shown that daily exposure to different products, whether chemical or natural, can cause irreversible damage to women’s reproductive health. Therefore it is necessary to use tests that evaluate the safety and efficacy of these products. Most reproductive toxicology tests are performedin vivo. However, in recent years, various cell culture methods, including embryonic stem cells and tissues have been developed with the aim of reducing the use of animals in toxicological tests. This is a major advance in the area of toxicology, as these systems have the potential to become a widely used tool compared within vivotests routinely used in reproductive biology and toxicology. The present review describes and highlights data onin vitroculture processes used to evaluate reproductive toxicity as an alternative to traditional methods usingin vivotests.

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“…This is of particular relevance for cosmetic formulations, as the EU has banned animal testing of cosmetic ingredients since 2013 [7]. This framework has stemmed the development of alternative methods for the safety assessment of topical ingredients and in vitro approaches based on cell culture have risen to prominence [8]. Many of these methodologies can also be highly relevant in efficacy testing of skin repair ingredients [9] since the impact in cellular mechanisms such as proliferation or migration can be more easily dissected in vitro.…”

Section: Introductionmentioning

confidence: 99%

Impact of Portuguese propolis on keratinocyte proliferation, migration and ROS protection: Significance for applications in skin products

Saraiva

Nicolai

Martins

et al. 2022

Intern J of Cosmetic Sci

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Objective: Propolis has been used since antiquity, but recent reports of its biological properties hint that it could be employed as a topical pharmaceutical and cosmetic ingredient. This work aims to probe the action of Portuguese propolis extracts on skin cells, providing mechanistic insights into its mode of action and preliminarily assessing its applicability as a skin repair ingredient. Methods:The total phenolic content of propolis extracts was measured by the Folin Ciocalteu method. The cytotoxic effect of propolis extracts in human keratinocytes was determined and non-cytotoxic concentrations of the extracts were used to study the impact on collective cell migration, cell cycle and intracellular ROS levels.Results: o significant impact was observed in collective cell migration, but one of the extracts mildly increased G2 phase while reducing the % of sub-G1 at a noncytotoxic concentration. The two extracts with higher phenolic content strongly prevented intracellular cellular ROS accumulation upon exposure to TBHP. Collectively, these results indicate that the putative beneficial effects of propolis extracts in skin repair may not be attributable to induction of collective cell migration but could be partially ascribed to the protection from oxidative stress, which could act in synergy with its well-known antimicrobial activity. Conclusion:These data support the applicability of this material in topical and cosmetic formulations and further in vivo assays should be conducted to fully characterize its efficacy and safety.

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Perspectives and strategies of alternative methods used in the risk assessment of personal care products

Cited by 7 publications

References 79 publications

Skin irritation potential of cosmetic preservatives: An exposure‐relevant study

Skin irritation potential of cosmetic preservatives: An exposure‐relevant study

In vitro culture systems as an alternative for female reproductive toxicology studies

Impact of Portuguese propolis on keratinocyte proliferation, migration and ROS protection: Significance for applications in skin products

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