Perspectives and Molecular Understanding of Pancreatic Cancer Stem Cells

Lakkakula, Saikrishna; Kasa, Prameswari; Momin, Saimila; Bhaskar, L. V. K. S.

doi:10.1007/978-981-32-9393-9_9

Cited by 1 publication

(1 citation statement)

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“…Owing to the heterogeneity in CSCs and technical difficulties in the CSC population isolation, multiple methodologies have been applied to enrich the isolation of exclusive CSC populations from heterogeneous cancer cells in pancreas tumor mass. Currently, these strategies used are limited to using the cell surface markers (e.g., EpCAM, CD133, CD44, CXCR4, ABCG2, CCR7, Oct4, Sox2, and Nanog), functional assays (spheroid formation, colony formation, ALDHs activity, SP assay), aldefluorine assay and Hoechst-33,342 dye method ( Table 1 ) [ 22 , 27 , 62 , 63 ]. As noted before, the presence of cell surface markers CD44+/CD24+/EpCAM+ or CD133 for CSCs in PC was first shown by Li et al and Hermann et al [ 21 , 64 ].…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Cancer and Therapy: Role and Regulation of Cancer Stem Cells

Barman¹,

Fatima²,

Singh

et al. 2021

IJMS

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Despite significant improvements in clinical management, pancreatic cancer (PC) remains one of the deadliest cancer types, as it is prone to late detection with extreme metastatic properties. The recent findings that pancreatic cancer stem cells (PaCSCs) contribute to the tumorigenesis, progression, and chemoresistance have offered significant insight into the cancer malignancy and development of precise therapies. However, the heterogeneity of cancer and signaling pathways that regulate PC have posed limitations in the effective targeting of the PaCSCs. In this regard, the role for K-RAS, TP53, Transforming Growth Factor-β, hedgehog, Wnt and Notch and other signaling pathways in PC progression is well documented. In this review, we discuss the role of PaCSCs, the underlying molecular and signaling pathways that help promote pancreatic cancer development and metastasis with a specific focus on the regulation of PaCSCs. We also discuss the therapeutic approaches that target different PaCSCs, intricate mechanisms, and therapeutic opportunities to eliminate heterogeneous PaCSCs populations in pancreatic cancer.

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