Perspective: Status and Future of Analytical Chemistry in India

Verma, Krishna K.

doi:10.1021/acs.analchem.6b04188

Anal. Chem.

2017

DOI: 10.1021/acs.analchem.6b04188

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Perspective: Status and Future of Analytical Chemistry in India

Krishna K. Verma

Abstract: Relative to many other areas in chemistry, analytical chemistry appears singularly lagging behind in India despite the commendable growth it had shown in the past both in teaching and research. Certain presumptions in policy making and current educational practices are believed to be the crux of the problem.

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2019

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Stability Studies of Rifampicin in Plasma and Urine of Tuberculosis Patients According to the European Medicines Agency Guidelines

et al. 2019

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Aim: The macrolide antibiotic rifampicin is prescribed against several infections, like tuberculosis disease. This drug decays to rifampicin quinone. Results/methodology: The biological fluids were diluted in a micellar solution and directly injected. Using a C18 column and a mobile phase of 0.15 M SDS-6% 1-pentanol phosphate-buffered at pH 7, running at 1 ml/min, the analytes were resolved in less than 15 min. The detection was by absorbance at 337 nm. Method was validated by the guidelines of the European Medicines Agency. Decomposition of rifampicin to rifampicin quinone was also studied. Discussion/conclusion: Procedure is rapid, easy-to-handle, economic, eco-friendly and with a high sample throughput. It was successfully used to monitor rifampicin in the plasma and urine of tubercular patients.

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Stability Studies of Rifampicin in Plasma and Urine of Tuberculosis Patients According to the European Medicines Agency Guidelines

et al. 2019

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Perspective: Status and Future of Analytical Chemistry in India

Cited by 1 publication

References 51 publications

Stability Studies of Rifampicin in Plasma and Urine of Tuberculosis Patients According to the European Medicines Agency Guidelines

Stability Studies of Rifampicin in Plasma and Urine of Tuberculosis Patients According to the European Medicines Agency Guidelines

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