Perspective on unraveling the versatility of ‘co-repressor’ complexes

Baymaz, H. Irem; Karemaker, Ino D; Vermeulen, Michiel

doi:10.1016/j.bbagrm.2015.06.012

Cited by 21 publications

(19 citation statements)

References 62 publications

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“…However, in recent times (supporting its initial discovery in yeast), there have been several reports that show recruitment of Sin3/HDAC complex at actively transcribed genes. This in fact is true for several other "corepressor complexes" like N-CoR/SMRT and NuRD complexes (Baymaz et al, 2015).…”

Section: Structure Of Sin3 Protein and Core Complexmentioning

confidence: 95%

“…However, it is important to mention that despite the initial discoveries of Sin3 as positive regulator of transcription in yeast, the mammalian Sin3/HDAC complex is commonly referred to as "corepressor" complex. This is primarily due to recruitment of HDAC activity that is linked to promoter hypoacetylation, chromatin condensation, and gene repression (Baymaz, Karemaker, & Vermeulen, 2015;Laugesen & Helin, 2014). However, in recent times (supporting its initial discovery in yeast), there have been several reports that show recruitment of Sin3/HDAC complex at actively transcribed genes.…”

Section: Structure Of Sin3 Protein and Core Complexmentioning

confidence: 97%

“…1; Kadamb et al, 2013). While the mechanism of repression mostly involves deacetylation of histone and nonhistone proteins, the mechanism for gene activation is less clear and may be HDAC independent (Baymaz et al, 2015;Kadamb et al, 2013). The dual regulation of transcription by Sin3 depends on the molecular and cellular conditions.…”

Section: Functions Of Sin3 Proteinmentioning

confidence: 98%

See 2 more Smart Citations

Emerging Roles of Epigenetic Regulator Sin3 in Cancer

Bansal

Gourichon

Farías

et al. 2016

Advances in Cancer Research

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Section: Structure Of Sin3 Protein and Core Complexmentioning

confidence: 95%

Section: Structure Of Sin3 Protein and Core Complexmentioning

confidence: 97%

Section: Functions Of Sin3 Proteinmentioning

confidence: 98%

See 1 more Smart Citation

Emerging Roles of Epigenetic Regulator Sin3 in Cancer

Bansal

Gourichon

Farías

et al. 2016

Advances in Cancer Research

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“…The three best characterized Hdac1/2 containing complexes, Sin3-Hdac, NuRD and CoREST, are essential during early embryonic development and also in adult tissue maintenance (McDonel et al, 2009;Kelly & Cowley, 2013). While these Hdac complexes were first identified as being transcriptional repressors, recent studies have revealed that they also have roles associated with gene activation (van Oevelen et al, 2010;Reynolds et al, 2013;Baymaz et al, 2015). These roles are thought to include fine-tuning of ongoing transcription and "priming" gene promoters for subsequent transcriptional responses (Reynolds et al, 2013;Laugesen & Helin, 2014).…”

Section: Introductionmentioning

confidence: 99%

Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal

et al. 2017

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Sin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we compare the composition of the Sin3a-Hdac complex between pluripotent embryonic stem (ES) and differentiated cells by establishing a method that couples two independent endogenous immunoprecipitations with quantitative mass spectrometry. We define the precise composition of the Sin3a complex in multiple cell types and identify the Fam60a subunit as a key defining feature of a variant Sin3a complex present in ES cells, which also contains Ogt and Tet1. Fam60a binds on H3K4me3-positive promoters in ES cells, together with Ogt, Tet1 and Sin3a, and is essential to maintain the complex on chromatin. Finally, we show that depletion of Fam60a phenocopies the loss of Sin3a, leading to reduced proliferation, an extended G1-phase and the deregulation of lineage genes. Taken together, Fam60a is an essential core subunit of a variant Sin3a complex in ES cells that is required to promote rapid proliferation and prevent unscheduled differentiation.

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“…Intriguingly, the above genes are major players of different histone modification mechanisms. For instance, SET domain proteins commonly regulate histone methylation [44][45][46] , whereas SAP30 is a key component of the Sin3-histone deacetylase (HDAC) complex that regulates histone deacetylation 47,48 . MBD9, on the other hand, has been demonstrated in A. thaliana to modulate development by modifying chromatin structure via histone acetylation and DNA methylation 49 .…”

Section: Discussionmentioning

confidence: 99%

A mycorrhizae-like gene regulates stem cell and gametophore development in mosses

et al. 2020

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Plant colonization of land has been intimately associated with mycorrhizae or mycorrhizaelike fungi. Despite the pivotal role of fungi in plant adaptation, it remains unclear whether and how gene acquisition following fungal interaction might have affected the development of land plants. Here we report a macro2 domain gene in bryophytes that is likely derived from Mucoromycota, a group that includes some mycorrhizae-like fungi found in the earliest land plants. Experimental and transcriptomic evidence suggests that this macro2 domain gene in the moss Physcomitrella patens, PpMACRO2, is important in epigenetic modification, stem cell function, cell reprogramming and other processes. Gene knockout and over-expression of PpMACRO2 significantly change the number and size of gametophores. These findings provide insights into the role of fungal association and the ancestral gene repertoire in the early evolution of land plants.

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Perspective on unraveling the versatility of ‘co-repressor’ complexes

Cited by 21 publications

References 62 publications

Emerging Roles of Epigenetic Regulator Sin3 in Cancer

Emerging Roles of Epigenetic Regulator Sin3 in Cancer

Fam60a defines a variant Sin3a‐Hdac complex in embryonic stem cells required for self‐renewal

A mycorrhizae-like gene regulates stem cell and gametophore development in mosses

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