Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review

Yazarlu, Omid; Iranshahi, Mehrdad; Kashani, Hamid Reza Khayat; Reshadat, Sara; Habtemariam, Solomon; Iranshahy, Milad; Hasanpour, Maede

doi:10.1016/j.phrs.2021.105841

Cited by 109 publications

(80 citation statements)

References 379 publications

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“…Wound healing is a complex process involving haemostasis, inflammation, proliferation and tissue remodelling [ 10 ]. Many phyto-therapeutic studies have been conducted on oral antiulcerogenic activity based on haemostasis [ 11 ]; antioxidant [ 12 , 13 , 14 ], antibacterial [ 15 ] and anti-inflammatory activities [ 11 , 16 , 17 , 18 , 19 ]; proliferation/angiogenesis [ 20 ]; and remodelling phase/re-epithelialisation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

HPLC/MSn Profiling and Healing Activity of a Muco-Adhesive Formula of Salvadora persica against Acetic Acid-Induced Oral Ulcer in Rats

et al. 2021

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Salvadora persica L. (S. persica, Siwak) is an ethnic plant that is widely used for improving oral hygiene. This study aimed to provide a phytochemical profiling of S. persica ethyl acetate fraction (SPEAF) and to evaluate the healing activity of a muco-adhesive formula of the fraction against acetic acid-induced oral ulcers in rats. HPLC-ESI-QTOF-MS-MS analysis of SPEAF resulted in the tentative identification of 56 metabolites containing fatty acids (23%), urea derivatives (10.5%) and sulphur compounds (10%), in addition to several amides, polyphenols and organic acids (6.5%, 5% and 2%, respectively). For the first time, 19 compounds were identified from S. persica. In vitro and in vivo experiments indicated that the extract is non-toxic. SPEAF exhibited superior healing activities compared to both the negative and positive control groups on days 7 and 14 of tongue ulcer induction. This was confirmed by histopathological examinations of haematoxylin and eosin-stained (H&E) and Masson’s trichrome-stained tongue sections. Moreover, SPEAF showed potent anti-inflammatory activities, as evidenced by the inhibited expression of interleukin-6 (IL-6) and tumour necrosis alpha (TNF-α). Moreover, SPEAF exhibited potent antioxidant activity, as it prevented malondialdehyde (MDA) accumulation, reduced glutathione (GSH) depletion and superoxide dismutase (SOD) exhaustion. SPEAF significantly enhanced hydroxyproline tongue content and upregulated collagen type I alpha 1 (Col1A1) mRNA expression. SPEAF also improved angiogenesis, as shown by the increased mRNA expression of the angiopoietin-1 (Ang-1). In conclusion, S. persica has a wide range of secondary metabolites and ameliorates acetic acid-induced tongue ulcers in rats. This can be attributed, at least partly, to its anti-inflammatory, antioxidant, procollagen and angiogenic activities. These findings provide support and validity for the use of S. persica as a traditional and conventional treatment for oral disorders.

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Section: Introductionmentioning

confidence: 99%

HPLC/MSn Profiling and Healing Activity of a Muco-Adhesive Formula of Salvadora persica against Acetic Acid-Induced Oral Ulcer in Rats

et al. 2021

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“…For its optimization, effective therapies using wound healing agents are required. 5,7,31 Of which, hydrogels have been proposed as strong drug delivery media for acute open wound management due to their high content of water, biocompatibility, and flexibility. 5,26 In this present study, we used gel formulation of B. racemosa extract for open wound treatment on rat models.…”

Section: Discussionmentioning

confidence: 99%

“…5 Several traditional medicines have been used in wound dressing to accelerate the healing process, including those consisting of plant extracts. 6,7 Emerging research has tried to provide evidence-based phytomedicines as a candidate to treat diseases including as substitute or addendum in wound management. [8][9][10] There have been many examples of plant-based traditional medicines possessing wound healing properties.…”

Section: Introductionmentioning

confidence: 99%

Acceleration of wound healing by topical application of gel formulation of Barringtonia racemosa (L.) Spreng kernel extract

et al. 2022

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Background: Phytomedicines are gaining a spotlight in wound management, where much research has suggested the wound healing potential of Barringtonia racemosa. The objective of this study was to investigate the effectiveness of B. racemosa kernel extract in accelerating wound healing process in animal models. Methods: B. racemosa kernel was extracted using ethanol:water (7:3) solvent and was then used as a bioactive ingredient in a Carbopol 940-based gel formulation in four different concentrations (1, 3, 5 and 7 ppm). A 3 cm diameter wound was made in the dorsal area of Rattus norvegicus rat and wound healing process was assessed up to 12 days using DESIGN (Depth, Exudate, Size of Inflammation/Infection, Granulation tissue, and Necrotic tissue) scoring system. Results: Our data suggested that the DESIGN scores were significantly different among concentration groups after the 3rd day onward suggesting B. racemosa extract accelerated the wound healing process. Rats treated with gel formulation containing 7 ppm of B. racemosa kernel extract had faster wound healing than that treated with topical Metcovazin. Conclusion: B. racemosa kernel extract was effective in accelerating wound healing on rats. Further study is warranted to purify the bioactive component and the action mechanism in wound healing process.

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“…Thus, many researchers have focused their attention to find solutions for rapid wound closure and developing an aesthetically satisfactory scar. To this aim, strategies including antibacterial ointments, synthetic growth factors, polyurethanes, polymeric hydrogels, and fiber dressings have been developed over the years [ 5 , 6 , 7 , 8 ]. Polymeric hydrogels showed the advantage of supporting a hydrated environment, adsorbing excess fluids [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings

Lungu

Paun

Peptanariu

et al. 2022

Gels

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Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific practices. In this conceptual framework, the present paper deals with the investigation of a hydrogel as bioabsorbable wound dressing. To this aim, chitosan was cross-linked with 2-formylphenylboronic acid to yield a hydrogel with antimicrobial activity. FTIR, NMR, and POM procedures have characterized the hydrogel from a structural and supramolecular point of view. At the same time, its biocompatibility and antimicrobial properties were also determined in vitro. Furthermore, in order to assess the bioabsorbable character, its biodegradation was investigated in vitro in the presence of lysosome in media of different pH, mimicking the wound exudate at different stages of healing. The biodegradation was monitored by gravimetrical measurements, SEM microscopy and fractal analyses of the images. The fractal dimension values and the lacunarity of SEM pictures were accurately calculated. All these successful investigations led to the conclusion that the tested materials are at the expected high standards.

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Perspective on the application of medicinal plants and natural products in wound healing: A mechanistic review

Cited by 109 publications

References 379 publications

HPLC/MSn Profiling and Healing Activity of a Muco-Adhesive Formula of Salvadora persica against Acetic Acid-Induced Oral Ulcer in Rats

HPLC/MSn Profiling and Healing Activity of a Muco-Adhesive Formula of Salvadora persica against Acetic Acid-Induced Oral Ulcer in Rats

Acceleration of wound healing by topical application of gel formulation of Barringtonia racemosa (L.) Spreng kernel extract

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings

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