Perspective insights into hydrogels and nanomaterials for ischemic stroke

Yu, Qingbo; Zhang, Jian; Yang, Dan; Zhu, Tao

doi:10.3389/fncel.2022.1058753

Cited by 6 publications

(5 citation statements)

References 159 publications

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“…MOFs display a porous structure and a significant surface area-to-volume ratio, facilitating enhanced drug loading. Their porous structure and surface modifications offer a high degree of flexibility, enabling effective targeted drug delivery and controlled release (Alkaff et al, 2020;Zenych et al, 2020;Ma et al, 2021;Yu et al, 2022b;Lin et al, 2022;Cheng et al, 2023;Ruscu et al, 2023).…”

Section: Nanomedicine Therapymentioning

confidence: 99%

Application of stimuli-responsive nanomedicines for the treatment of ischemic stroke

Zhan,

Dai,

Ding

et al. 2024

Front. Bioeng. Biotechnol.

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Ischemic stroke (IS) refers to local brain tissue necrosis which is caused by impaired blood supply to the carotid artery or vertebrobasilar artery system. As the second leading cause of death in the world, IS has a high incidence and brings a heavy economic burden to all countries and regions because of its high disability rate. In order to effectively treat IS, a large number of drugs have been designed and developed. However, most drugs with good therapeutic effects confirmed in preclinical experiments have not been successfully applied to clinical treatment due to the low accumulation efficiency of drugs in IS areas after systematic administration. As an emerging strategy for the treatment of IS, stimuli-responsive nanomedicines have made great progress by precisely delivering drugs to the local site of IS. By response to the specific signals, stimuli-responsive nanomedicines change their particle size, shape, surface charge or structural integrity, which enables the enhanced drug delivery and controlled drug release within the IS tissue. This breakthrough approach not only enhances therapeutic efficiency but also mitigates the side effects commonly associated with thrombolytic and neuroprotective drugs. This review aims to comprehensively summarize the recent progress of stimuli-responsive nanomedicines for the treatment of IS. Furthermore, prospect is provided to look forward for the better development of this field.

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Section: Nanomedicine Therapymentioning

confidence: 99%

Application of stimuli-responsive nanomedicines for the treatment of ischemic stroke

Zhan,

Dai,

Ding

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…MOFs display a porous structure and a significant surface area-to-volume ratio, facilitating enhanced drug loading. Their porous structure and surface modifications offer a high degree of flexibility, enabling effective targeted drug delivery and controlled release (Alkaff et al, 2020;Zenych et al, 2020;Yu et al, 2022b;Lin et al, 2022;Cheng et al, 2023;Ruscu et al, 2023).…”

Section: Nanomedicine Therapymentioning

confidence: 99%

Bioactive Materials for Disease Diagnosis and Therapy

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…Additionally, stroke therapies need to be improved via deploying novel controllable drug delivery systems. In this era, various nanoarchitectures, including lipid-based compositions (liposomes, lipid-based carriers), polymeric structures (micelles, dendrimers, and nanogels), and inorganic-based configurations (Metallic, super magnetic metal oxides, and quantum dots) could be generated to carry or encapsulate drugs and release them in a targeted region ( Tang et al, 2023 ; Wang et al, 2023 ; Yu et al, 2023 ). Figures 3A , B schematically represent different morphologies created using the nanoscience, along with their pros and cons.…”

Section: Nanomedicines For Strokementioning

confidence: 99%

Current trends and future perspectives of stroke management through integrating health care team and nanodrug delivery strategy

Han,

Qin,

Mei

et al. 2023

Front. Cell. Neurosci.

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Stroke is accounted as the second-most mortality and adult disability factor in worldwide, while causes the bleeding promptly and lifetime consequences. The employed functional recovery after stroke is highly variable, allowing to deliver proper interventions to the right stroke patient at a specific time. Accordingly, the multidisciplinary nursing team, and the administrated drugs are major key-building-blocks to enhance stroke treatment efficiency. Regarding the healthcare team, adequate continuum of care have been declared as an integral part of the treatment process from the pre-hospital, in-hospital, to acute post-discharge phases. As a curative perspective, drugs administration is also vital in surviving at the early step and reducing the probability of disabilities in later. In this regard, nanotechnology-based medicinal strategy is exorbitantly burgeoning. In this review, we have highlighted the effectiveness of current clinical care considered by nursing teams to treat stroke. Also, the advancement of drugs through synthesis of miniaturized nanodrug formations relating stroke treatment is remarked. Finally, the remained challenges toward standardizing the healthcare team and minimizing the nanodrugs downsides are discussed. The findings ensure that future works on normalizing the healthcare nursing teams integrated with artificial intelligence technology, as well as advancing the operative nanodrugs can provide value-based stroke cares.

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Perspective insights into hydrogels and nanomaterials for ischemic stroke

Cited by 6 publications

References 159 publications

Application of stimuli-responsive nanomedicines for the treatment of ischemic stroke

Application of stimuli-responsive nanomedicines for the treatment of ischemic stroke

Bioactive Materials for Disease Diagnosis and Therapy

Current trends and future perspectives of stroke management through integrating health care team and nanodrug delivery strategy

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