Perspective Chapter: Dental Home – A Neglected Primary Oral Health Care Concept

Abstract

Tooth decay, if left untreated even in the earliest stages of life, can have serious implications for a child’s long-term health and well-being. Early preventive care is a sound health and economic investment. Dental assessments and evaluations for children during their first year of life have been recommended by the American Academy of Pediatric Dentistry (AAPD) and the American Association of Pediatrics (ADA). Establishment of dental home and use of anticipatory guidance is one of the concepts in comprehensive oral health care. AAPD and ADA support the concept of a “dental home,” which is the ongoing relationship between the dentist and the patient. Establishing a dental home means that a child’s oral health care is managed in a comprehensive, continuously accessible, coordinated, and family-centered way by a licensed dentist. The dental professional’s ability to provide optimal oral health care, beginning from when the child is 1-year-old, dental visit leading to preventive care and treatment as part of an overall oral health care foundation for life, is enhanced by dental home. The establishment of the dental home also assures appropriate referral to dental specialists when availability of direct care is not possible within the dental home.

Parkinson’s Disease: Advances in Treatment and the Syntheses of Various Classes of Pharmaceutical Drug Substances

“…Pramipexole dihydrochloride ( 42 ), a nonergot dopamine agonist, is marketed as Mirapex drug product (Boehringer Ingelheim, Ridgefield, USA), and it helps to improve movement-related symptoms . Several approaches have been reported for the synthesis of Pramipexole dihydrochloride ( 42 ). − The initial synthesis (Scheme ) , began with elaboration of aminoketone 37 to a key racemic diamine intermediate (±)- 39 . This was carried out in three steps via bromination of 37 using bromine in acetic acid followed by amino-thiazole formation with thiourea to provide protected tetrahydro­benzothiazole ( 38 ).…”

“…Since this initial report, there have been several publications that involve further improvements, either by using a chiral salt to resolve the two enantiomers of racemic diamine (±)- 39 or using chiral chromatography for separation. , Recent reports focused on installing the propyl group on the diamine after resolution of the diamine (±)- 39 through either alkylation, reductive amination, or modification of the acylation/reduction route as shown in Scheme . − Recently, a chemoenzymatic system was also used to resolve the two enantiomers via selective acylation of the undesired diamine …”