Persons with first episode psychosis have distinct profiles of social cognition and metacognition

Ferrer-Quintero, Marta; Fernández, Daniel; López-Carrilero, Raquel; Birulés, Irene; Barajas, Ana; Lorente-Rovira, Esther; Díaz-Cutraro, Luciana; Verdaguer, Marina; García‐Mieres, Helena; Sevilla‐Llewellyn‐Jones, Julia; Gutiérrez-Zotes, Alfonso; Grasa, Eva; Pousa, Esther; Huerta‐Ramos, Elena; Peláez, Trinidad; Barrigón, María Luisa; González-Higueras, Fermín; Ruiz-Delgado, Isabel; Cid, Jordi; Moritz, Steffen; Ochoa, Susana

doi:10.1038/s41537-021-00187-8

Cited by 8 publications

(5 citation statements)

References 80 publications

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“…Secondly, it has been studied in different subpopulations of psychosis showing positive results in different diagnoses and stages of the illness. Additionally, different profiles of patients could benefit from MCT considering their baseline assessment ( Ferrer-Quintero et al, 2021 , 2022 ). Thirdly, it is standardized through a manual guide, that allows comparison between different hospitals and facilitates delivery by any mental health professional with adequate training.…”

Section: Expected Results and Discussionmentioning

confidence: 99%

Efficacy of the combination of water aerobics and metacognitive training on psychological and physical health variables and their relationship with SP1 and SP4 biomarkers in people with psychosis: a study protocol

Ochoa,

Verdaguer-Rodríguez,

Batlle

et al. 2024

Front. Psychol.

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BackgroundMetacognitive Training (MCT) is widely used and effective in reducing positive symptoms in psychosis. Physical exercise, such as Water Aerobics (WA), improves general health, quality of life and symptoms as a low impact activity that allows social interactions. Preliminary results suggest a relationship between dopamine and psychotic symptoms, through SP transcription factors, SP1 and SP4 biomarkers. The aims of the project are to evaluate the efficacy of a combined intervention (WA and MCT) for psychosis to improve psychotic symptoms, physical health, and transcription levels of SP biomarkers.Materials and methodsThis is a unicentric randomized controlled trial of three parallel intervention groups: MCT, WA and combined intervention. The estimated sample will be 48 patients with a psychotic spectrum disorder diagnosis. The assessment will be performed at baseline and at 2-months’ follow-up. Instruments used in the assessment will include clinical, cognitive, metacognitive, social cognitive and psychosocial variables.DiscussionThis will be the first study investigating the impact of the combination of MCT and WA in psychosis. Moreover, it will be the first study analyzing changes in the transcriptional biomarkers SP1 and SP4 after interventions. The results of this study may have clinical implications contributing to the improvement of treatment selection.Clinical trial registrationhttps://clinicaltrials.gov/, identifier: NCT05455593.

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Section: Expected Results and Discussionmentioning

confidence: 99%

Efficacy of the combination of water aerobics and metacognitive training on psychological and physical health variables and their relationship with SP1 and SP4 biomarkers in people with psychosis: a study protocol

Ochoa,

Verdaguer-Rodríguez,

Batlle

et al. 2024

Front. Psychol.

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“…However, using keywords such as decentering, psychosis and/or schizophrenia, no studies were found. Instead, several studies investigated “decentration” in patients with schizophrenia 50 – 52 along with self-reflectivity, understanding of others’ minds and mastery. It is defined as the ability to see others as having independent motives like theory of mind and could be considered as one component of social cognition whereas decentering is focused on self-awareness.…”

Section: Discussionmentioning

confidence: 99%

Effects and safety of virtual reality-based mindfulness in patients with psychosis: a randomized controlled pilot study

Lee,

Kim,

Lee

et al. 2023

Schizophr

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Virtual reality (VR) technology can be a supporting tool to enhance mindfulness. Recently, many research using VR-based mindfulness (VBM) has been carried out in various psychiatric disorders but not in psychosis. We investigated safety and effects of virtual reality-based mindfulness (VBM) in patients with psychosis as a pilot study. Sixty-four patients were randomly assigned to VBM or to VR control. For VBM, education and meditation videos were provided. For VR control, 3-dimensional natural scenes were shown. Both programs consisted of 8 weekly sessions, each lasting about 30 min. Pre- and post-assessments were performed using the experiences questionnaire (EQ), psychotic symptom rating scales-delusion (PSYRATS-D), PSYRATS-auditory hallucinations (AH), motivation and pleasure scale-self rating (MAP-SR) and etc. The safety questionnaire was also surveyed after 1st and 8th session. Physiological measures such as skin conductance level (SCL), heart rate (HR) and RR interval, were collected during the VR interventions. Limited individuals participated in the safety questionnaire and physiological measures. All the results were presented in mean and standard deviation. We did not observe significant results in group x time interaction and main effects of group and time in the decentering and clinical scales. However, within group comparison showed that patients randomized to VBM showed increased decentering (p = 0.029) and decreased amount (p = 0.032) and duration of preoccupation (p = 0.016) in the PSYRATS-D. For the feelings and motivations about close caring relationships of the MAP-SR, we observed a significant group x time interaction (p = 0.027). The frequency of VR sickness was high but its severity was mild. There were significant differences only in HR over time in the VBM group (p = 0.01). These results suggest that VBM was not more effective in reducing decentering and psychiatric symptoms than VR control but its adversity was modest.

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“…It consists of four core components: theory of mind (ToM), emotional cognition, inferential explanations (attributional bias), and social perception. 2 …”

Section: Introductionmentioning

confidence: 99%

The Neural Correlates of the Recognition of Emotional Intensity Deficits in Major Depression: An ERP Study

Zhang

Chen-guang

Wang

et al. 2023

NDT

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Purpose Deficits in facial emotional intensity recognition have been associated with social cognition in patients with major depression. The study examined multiple event-related potential (ERP) components in patients with major depression and investigated the relationships between ERPs, social cognition, and clinical features. Participants and Methods Thirty-one patients met DSM-IV diagnosis of depression and 31 healthy participants completed the emotion intensity recognition task (EIRT), while ERPs were recorded. Data on ERP components (P100, N170, P200, and P300) were analyzed. Results The behavioral results showed that patients with major depression performed worse on EIRT, including all six categories of emotions (sadness, disgust, happiness, surprise, anger, and fear), compared to healthy participants. The ERP results showed that patients with major depression exhibited higher P100 amplitudes for sad and happy faces than healthy participants; P300 amplitudes induced by sad and surprise faces were also higher than in healthy participants, mainly in the central and temporal lobes. A positive correlation was found between sadness intensity scores and P100 amplitudes in patients with major depression. Conclusion Patients with major depression are biased in their identification of facial expressions indicating emotional intensity. Specifically, they have emotional biases in the early and late stages of cognitive processing, mainly in the form of sensitivity to sad stimuli. It may lead to a persistent rumination of sadness that is detrimental to the remission of depression. Additionally, patients with major depression devote different amounts of cognitive resources for different intensities of sad faces during the preconscious stage of cognitive processing. The more intense their perception of sadness, the more cognitive resources they devote. Therefore, the assessment of the intensity of facial expressions is an important research topic, with clinical implications on social cognitive function in patients with major depression.

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Persons with first episode psychosis have distinct profiles of social cognition and metacognition

Cited by 8 publications

References 80 publications

Efficacy of the combination of water aerobics and metacognitive training on psychological and physical health variables and their relationship with SP1 and SP4 biomarkers in people with psychosis: a study protocol

Efficacy of the combination of water aerobics and metacognitive training on psychological and physical health variables and their relationship with SP1 and SP4 biomarkers in people with psychosis: a study protocol

Effects and safety of virtual reality-based mindfulness in patients with psychosis: a randomized controlled pilot study

The Neural Correlates of the Recognition of Emotional Intensity Deficits in Major Depression: An ERP Study

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