Personalizing Colorectal Cancer Screening: A Systematic Review of Models to Predict Risk of Colorectal Neoplasia

Risk Prediction Models for Colorectal Cancer: A Systematic Review

“…Although we cannot exclude publication bias or the possibility that there are other risk models that we did not identify, using this systematic approach enabled us to identify over three times as many risk models as reported in previous reviews in this area (8,9). This review is, therefore, the most comprehensive to date and the inclusion of less well cited risk models allows us to demonstrate for the first time the relative performance of simple and more complex models.…”

“…A number of risk prediction models for colorectal cancer have been developed and two previous reviews of these have been published (8,9). However, neither was comprehensive, and since those reviews were published several new risk models have been developed.…”

Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer

“…Th e goal is to predict subgroups of patients with a high prevalence of important precancerous lesions benefi ting most from referral directly to colonoscopy, whereas the subgroups with a predicted lower risk (prevalence) of important precancerous lesions are referred for screening tests with less risk and cost than colonoscopy. Risk stratifi cation has been poorly accepted because of limited accuracy in discriminating high-and low-prevalence subgroups ( 27 ). However, recent validated models appear to be simple to apply and had substantial accuracy in defi ning high-and low-risk groups for advanced adenomas ( 28,29 ).…”

Faecal haemoglobin concentration and personalised assessment of the risk of colorectal neoplasia

“…It has been suggested that a personalised approach to screening could enable those at greatest risk to be referred for colonoscopy, optimising resource use and ultimately individual outcomes: this recent opinion piece detailed some interesting concepts and the work supporting this potentially useful riskscoring approach to CRC screening (14). In addition, a comprehensive systematic review of risk prediction models that could be used for personalisation of screening strategies has been recently published, although few to date actually incorporate f-Hb, probably the most relevant variable in assessment of risk (15).…”