Personalized surgical planning for coronary bypass graft configurations using patient-specific computational modeling to avoid flow competition in arterial grafts

Abstract

ObjectivesFlow competition between coronary artery bypass grafts (CABG) and native coronary arteries is a significant problem affecting arterial graft patency. The objectives of this study were to compare the predictive hemodynamic flow resulting from various total arterial grafting configurations and to evaluate whether the use of computational fluid dynamics (CFD) models capable of predicting flow can assist surgeons to make better decisions for individual patients by avoiding poorly functioning grafts.MethodsSixteen cardiac surgeons declared their preferred CABG configuration using bilateral internal mammary and radial arteries for each of 5 patients who had differing degrees of severe triple vessel coronary disease. Surgeons selected both a preferred 'aortic' strategy, with at least one graft arising from the ascending aorta, and a preferred “anaortic” strategy which could be performed as a “no-aortic touch” operation. CT coronary angiograms of the 5 patients were coupled to CFD models using a novel flow solver “COMCAB.” Twelve different CABG configurations were compared for each patient of which 4 were “aortic” and 8 were “anaortic.” Surgeons then selected their preferred grafting configurations after being shown predictive hemodynamic metrics including functional assessment of stenoses (instantaneous wave-free ratio; fractional flow reserve), transit time flowmetry graft parameters (mean graft flow; pulsatility index) and myocardial perfusion.ResultsA total of 87.5% (7/8) of “anaortic” configurations compared to 25% (1/4) of “aortic” configurations led to unsatisfactory grafts in at least 1 of the 5 patients (P = 0.038). The use of the computational models led to a significant decrease in the selection of unsatisfactory grafting configurations when surgeons employed “anaortic” (21.25% (17/80) vs. 1.25% (1/80), P < 0.001) but not “aortic” techniques (5% (4/80) vs. 0% (0/80), P = 0.64). Similarly, there was an increase in the selection of ideal configurations for “anaortic” (6.25% (5/80) vs. 28.75% (23/80), P < 0.001) but not “aortic” techniques (65% (52/80) vs. 61.25% (49/80), P = 0.74). Furthermore, surgeons who planned to use more than one unique “anaortic” configuration across all 5 patients increased (12.5% (2/16) vs. 87.5% (14/16), P<0.001).Conclusions“COMCAB” is a promising tool to improve personalized surgical planning particularly for CABG configurations involving composite or sequential grafts which are used more frequently in anaortic operations.

CCTA-based CABG SYNTAX Score: A Tool to Evaluate Completeness of Coronary Segment Revascularization after Bypass Surgery

“…After graft placement, antegrade coronary ow through and beyond the native coronary artery stenosis can be reversed (28,29). Competitive ow from the native coronary artery into the bypass graft remains an investigational issue (30). Recently, the concept of imbalance between the global luminal volume of the supply vessel and the mass of myocardium supplied by that vessel, the so-called V/M ratio, has been implicated as one of the causes of persisting ischemic symptoms when a graft is anastomosed in the middle of a long and diffusely diseased vessel (31)(32)(33)(34).…”

CCTA-based CABG SYNTAX Score: a tool to evaluate completeness of coronary segment revascularization after bypass surgery

“…After graft placement, antegrade coronary flow through and beyond the native coronary artery stenosis can be reversed [ 31 , 32 ]. Competitive flow from the native coronary artery into the bypass graft remains an investigational issue [ 33 ]. Results of RCTs have demonstrated similar graft failure rates and short-term clinical outcomes between FFR-guided and angiography-guided CABG [ 17 , 21 ].…”