Personalized Nutrition for Management of Micronutrient Deficiency—Literature Review in Non-bariatric Populations and Possible Utility in Bariatric Cohort

Abstract

Background Bariatric surgery can effectively treat morbid obesity; however, micronutrient deficiencies are common despite recommendations for high-dose supplements. Genetic predisposition to deficiencies underscores necessary identification of high-risk candidates. Personalized nutrition (PN) can be a tool to manage these deficiencies. Methods Medline, PubMed, and Google Scholar were searched. Articles involving genetic testing, micronutrient metabolism, and bariatric surgery were included. Results Studies show associations between genetic variants and micronutrient metabolism. Research demonstrates genetic testing to be a predictor for outcomes among obesity and bariatric surgery populations. There is limited research in bariatric surgery and micronutrient genetic variants. Conclusion Genotype-based PN is becoming feasible to provide an effective treatment of micronutrient deficiencies associated with bariatric surgery. The role of genomic technology in micronutrient recommendations needs further investigation.

Immunometabolism, Micronutrients, and Bariatric Surgery: The Use of Transcriptomics and Microbiota-Targeted Therapies

“…Understanding the role of micronutrients in the microbiome function, defining genetic factors that affect the micronutrient metabolism and interindividual variations in response to therapies for GM health, and identifying effective biomarkers of the micronutrient function may significantly contribute to developing personalized nutrition for the BS population. A review discussing genetic variants that affect micronutrient status has been published recently [10]. This narrative review aims to highlight common micronutrient deficiencies associated with BS patients and the relationship between micronutrients and GM function, particularly immunometabolism.…”