Personalized nanomedicine advancements for stem cell tracking

Janowski, Mirosław; Bulte, Jeff W.M.; Walczak, Piotr

doi:10.1016/j.addr.2012.07.008

Cited by 68 publications

(62 citation statements)

References 327 publications

(296 reference statements)

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“…Dispersed myelin fibers within the cortex or even fasciculated tracts in the striatum are beyond sensitivity limits and practically undetectable. Moreover, we found that the therapeutic benefit is highly dependent on the extent of cell distribution, suggesting that MRI cell tracking using either fluorine or iron oxide MR contrast agents may be equally important (Janowski et al, 2012; Srivastava and Bulte, 2014). Cell delivery technique such as MRI-guided intraarterial injection may further improve cell biodistribution (Gorelik et al, 2012; Walczak et al, 2016).…”

Section: Discussionmentioning

confidence: 95%

Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin

Lyczek

Arnold

Zhang

et al. 2017

Experimental Neurology

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The therapeutic effect of glial progenitor transplantation in diseases of dysmyelination is currently attributed to the formation of new myelin. Using magnetic resonance imaging (MRI), we show that the therapeutic outcome in dysmyelinated shiverer mice is dependent on the extent of cell migration but not presence of mature and compact myelin. Human or mouse glial restricted progenitors (GRPs) were transplanted into rag2−/− shiverer mouse neonates and followed for over one year. Mouse GRPs produced mature myelin as detected with multi-parametric MRI, but showed limited migration without extended animal lifespan. In sharp contrast, human GRPs migrated extensively and significantly increased animal survival, but production of mature myelin did not occur until 46 weeks post-grafting. We conclude that human GRPs can extend the survival of transplanted shiverer mice prior to production of mature myelin, while mouse GRPs fail to extend animal survival despite early presence of mature myelin. This paradox suggests that transplanted GRPs provide therapeutic benefits through biological processes other than mature myelin capable to facilitate rapid conduction, challenging the current dogma of the role of myelin in the function of the central nervous system.

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Section: Discussionmentioning

confidence: 95%

Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin

Lyczek

Arnold

Zhang

et al. 2017

Experimental Neurology

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“…[126, 128] Structure, fabrication, characteristics and optical imaging applications of UCNPs have recently been reviewed in excellent articles. [126–131] Owing to the well-established synthetic procedures and facile surface chemistries, UCNPs are increasingly being employed for diverse applications such as cell tracking [132], small animal imaging [130], drug delivery [133], photothermal [134], photodynamic [133] and combination therapies. [135, 136]…”

Section: Radiolabeled Nanomaterials For Cancer Theranosticsmentioning

confidence: 99%

Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics

Goel

England

Chen

et al. 2017

Advanced Drug Delivery Reviews

166

106

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Development of novel imaging probes for cancer diagnosis is critical for early disease detection and management. The past two decades have witnessed a surge in the development and evolution of radiolabeled nanoparticles as a new frontier in personalized cancer nanomedicine. The dynamic synergism of positron emission tomography (PET) and nanotechnology combines the sensitivity and quantitative nature of PET with the multifunctionality and tunability of nanomaterials, which can help overcome certain key challenges in the field. In this review, we discuss the recent advances in radionanomedicine, exemplifying the ability to tailor the physicochemical properties of nanomaterials to achieve optimal in vivo pharmacokinetics and targeted molecular imaging in living subjects. Innovations in development of facile and robust radiolabeling strategies and biomedical applications of such radionanoprobes in cancer theranostics are highlighted. Imminent issues in clinical translation of radiolabeled nanomaterials are also discussed, with emphasis on multidisciplinary efforts needed to quickly move these promising agents from bench to bedside.

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“…58,59 The MRI "homing" analysis method of transplanted stem cells occurs by the use of contrast agent. Nowadays, several available magnetic nanoparticles exist, 56 and the most commonly used one is iron oxide. 60 The processes by which nanoparticles are internalized by cells are not fully elucidated; however, mechanisms of endocytosis well described in the literature are pointed out as the main routes of internalization, including: i) internalization mediated by membrane receptors, ii) internalization independent of clathrin and caveolin, iii) clathrin-mediated internalization, iv) internalization mediated by caveolin, and v) transfection agent mediated internalization by poly-L-lysine (PLL), as shown in Figure 1.…”

Section: Nanobiotechnology: Possibilitiesmentioning

confidence: 99%

“…A major challenge is the lack of consistent data on stem cells' survival, distribution, and repair process leading to functional recovery in in vivo experiments. 56 To address these issues, a method of noninvasive cellular analysis is more efficient than conventional histopathological techniques, and provides unique information about cell behavior over time. 57 In this sense, several imaging modalities are available, including computerized tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), computed tomography photon emission tomography (SPECT), optical imaging, and ultrasound.…”

Section: Nanobiotechnology: Possibilitiesmentioning

confidence: 99%

Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review

Alvarim¹,

Nucci²,

Mamani³

et al. 2014

IJN

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The increase in clinical trials assessing the efficacy of cell therapy for structural and functional regeneration of the nervous system in diseases related to the aging brain is well known. However, the results are inconclusive as to the best cell type to be used or the best methodology for the homing of these stem cells. This systematic review analyzed published data on SPION (superparamagnetic iron oxide nanoparticle)-labeled stem cells as a therapy for brain diseases, such as ischemic stroke, Parkinson’s disease, amyotrophic lateral sclerosis, and dementia. This review highlights the therapeutic role of stem cells in reversing the aging process and the pathophysiology of brain aging, as well as emphasizing nanotechnology as an important tool to monitor stem cell migration in affected regions of the brain.

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Personalized nanomedicine advancements for stem cell tracking

Cited by 68 publications

References 327 publications

Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin

Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin

Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics

Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review

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