Personalized mitral valve closure computation and uncertainty analysis from 3D echocardiography

Grbić, Saša; Easley, Thomas F.; Mansi, Tommaso; Bloodworth, Charles H.; Pierce, Eric T.; Voigt, Ingmar; Neumann, Dominik; Krebs, Julian; Yuh, David D.; Jensen, Morten Ø.; Comanicìu, Dorin; Yoganathan, Ajit P.

doi:10.1016/j.media.2016.03.011

Cited by 14 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Up to date, it is not possible to retrieve patient‐specific MV models with the complex chordae topology from echo because of limitations in image spatial resolution. In this context, echo‐based computational models that study MV function and treatment commonly use complementary segmentation and modeling approaches based on optimization methods, parametric modeling using anatomic landmarks points, multiscale image‐based geometry, and generalized anatomical models from literature‐derived data . Fortunately, the field of transcatheter MV therapy is quickly evolving, and as technology improves, the use of multimodality cardiac imaging techniques that combine echo, CT‐based planning, and imaging fusion techniques is expected to play a more dominant role in these minimally invasive procedures …”

Section: Discussionmentioning

confidence: 99%

Transapical mitral valve repair with neochordae implantation: FSI analysis of neochordae number and complexity of leaflet prolapse

Caballero

Mao

McKay

et al. 2019

Numer Methods Biomed Eng

View full text Add to dashboard Cite

Transapical mitral valve repair with neochordae implantation is a relatively new minimally invasive technique to treat primary mitral regurgitation. Quantifying the complex biomechanical interaction and interdependence between the left heart structures and the neochordae during this procedure is technically challenging. The aim of this parametric computational study is to investigate the immediate effects of neochordae number and complexity of leaflet prolapse on restoring physiologic left heart dynamics after optimal transapical neochordae repair procedures. Neochordae implantation using three and four sutures was modeled under three clinically relevant prolapse conditions: isolated P2, multi‐scallop P2/P3, and multi‐scallop P2/P1. A fluid‐structure interaction (FSI) modeling framework was used to evaluate the left heart dynamics under baseline, prerepair, and postrepair states. Despite immediate restoration of leaflet coaptation and no residual mitral regurgitation in all postrepair models, the average and peak stresses in the repaired scallop(s) increased >40% and >100%, respectively, compared with the baseline state. Additionally, anterior mitral leaflet marginal chordae tension increased >30%, while posterior mitral leaflet chordae tension decreased at least 30%. No marked differences in hemodynamic performance, in native and neochordae forces, and in leaflet stress were found when implanting three or four sutures. We report, to our knowledge, the first set of time‐dependent in silico FSI human neochordae tension measurements during transapical neochordae repair. This work represents a further step towards an improved understanding of the biomechanical outcomes of minimally invasive mitral valve repair procedures.

show abstract

Section: Discussionmentioning

confidence: 99%

Transapical mitral valve repair with neochordae implantation: FSI analysis of neochordae number and complexity of leaflet prolapse

Caballero

Mao

McKay

et al. 2019

Numer Methods Biomed Eng

View full text Add to dashboard Cite

show abstract

“…Computational models have been created based on 2-and 3-dimensional echocardiography, as well as magnetic resonance imaging and computed tomography. These have generated biomechanical data on the healthy and diseased MV-LV relationship and different surgical techniques [17][18][19][20][21][22][23][24]. Furthermore, the models have predicted the observed role of MV elongation and papillary muscle anterior malposition in altering fluid interactions with the MV and driving LV outflow tract obstruction in hypertrophic cardiomyopathy [25,26].…”

Section: Biomechanical Foundations Of Mitral-ventricular Interaction ...mentioning

confidence: 99%

Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

et al. 2023

Self Cite

View full text Add to dashboard Cite

The geometrical details and biomechanical relationships of the mitral valve–left ventricular apparatus are very complex and have posed as an area of research interest for decades. These characteristics play a major role in identifying and perfecting the optimal approaches to treat diseases of this system when the restoration of biomechanical and mechano-biological conditions becomes the main target. Over the years, engineering approaches have helped to revolutionize the field in this regard. Furthermore, advanced modelling modalities have contributed greatly to the development of novel devices and less invasive strategies. This article provides an overview and narrative of the evolution of mitral valve therapy with special focus on two diseases frequently encountered by cardiac surgeons and interventional cardiologists: ischemic and degenerative mitral regurgitation.

show abstract

“…A particular area of study that has seen major advancements from in silico, imagebased modeling is that of MV dynamics. Pioneering the clinical application of new computational technologies, researchers have used real-time 3D echocardiography to generate patientspecific computational models of the MV (6)(7)(8)(9)(10)(11). Using these models, publications have revealed pathological dynamics and generated useful quantifications based on valvular geometry.…”

Section: In Silico Modelingmentioning

confidence: 99%

Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities of Ex Vivo Heart Simulation

Park

Zhu

Imbrie-Moore

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

The field of heart valve biomechanics is a rapidly expanding, highly clinically relevant area of research. While most valvular pathologies are rooted in biomechanical changes, the technologies for studying these pathologies and identifying treatments have largely been limited. Nonetheless, significant advancements are underway to better understand the biomechanics of heart valves, pathologies, and interventional therapeutics, and these advancements have largely been driven by crucial in silico, ex vivo, and in vivo modeling technologies. These modalities represent cutting-edge abilities for generating novel insights regarding native, disease, and repair physiologies, and each has unique advantages and limitations for advancing study in this field. In particular, novel ex vivo modeling technologies represent an especially promising class of translatable research that leverages the advantages from both in silico and in vivo modeling to provide deep quantitative and qualitative insights on valvular biomechanics. The frontiers of this work are being discovered by innovative research groups that have used creative, interdisciplinary approaches toward recapitulating in vivo physiology, changing the landscape of clinical understanding and practice for cardiovascular surgery and medicine.

show abstract

Personalized mitral valve closure computation and uncertainty analysis from 3D echocardiography

Cited by 14 publications

References 26 publications

Transapical mitral valve repair with neochordae implantation: FSI analysis of neochordae number and complexity of leaflet prolapse

Transapical mitral valve repair with neochordae implantation: FSI analysis of neochordae number and complexity of leaflet prolapse

Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

Heart Valve Biomechanics: The Frontiers of Modeling Modalities and the Expansive Capabilities of Ex Vivo Heart Simulation

Contact Info

Product

Resources

About