Personalized Medicine and the Treatment of Hypertension

Melville, Sarah; Byrd, James Brian

doi:10.1007/s11906-019-0921-3

Cited by 32 publications

(25 citation statements)

References 43 publications

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“…Current guidelines for the diagnosis and treatment of hypertension offer convenient heuristic algorithms for clinicians. However, they are limited by their involving little diagnostic testing and therefore are not highly personalized to the pathophysiology of individual patients, while more personalized treatment approaches might be useful [27] . Additionally, while a standardized treatment strategy for HTN will prove effective in most cases, a more personalized approach could be useful in selected patients, such as those who fail to respond to treatment [28] .…”

Section: Hypertensionmentioning

confidence: 99%

“…Additionally, while a standardized treatment strategy for HTN will prove effective in most cases, a more personalized approach could be useful in selected patients, such as those who fail to respond to treatment [28] . The rationale for personalized therapy of HTN, obstacles to its implementation, together with examples of personalization measures, are discussed elsewhere [27] . A framework for the personalized treatment of HTN based, on the one hand, on a trade-off between simplicity and personalization and, on the other hand, on a classification of treatment approaches into low, medium, or high information burden approaches has also been proposed [28] .…”

Section: Hypertensionmentioning

confidence: 99%

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Precision medicine approaches in metabolic disorders and target organ damage: where are we now, and where are we going?

Lonardo¹,

Byrne²,

Targher³

2021

MTOD

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In this review, we discuss selected topics which are relevant to implementing precision medicine in metabolic disorders. Personalization of diet and exercise may help in preventing obesity and type 2 diabetes (T2D). Weight loss should be personalized based on age, sex, ethnicity, and coexisting comorbidities. Advances in our understanding of the pathophysiology, genetics, and epigenetics of obesity promise to offer tailored management options. Careful risk assessment is necessary prior to intervention. Risk may be underestimated, e.g., in women, in different ethnic groups, and in people with T2D. More personalized approaches could be useful among persons who failed to respond to traditional risk factor management, such as pharmacological treatment for dyslipidemia and arterial hypertension. Nonalcoholic fatty liver disease/metabolic-associated fatty liver disease (NAFLD/MAFLD) is both a cause and an effect of altered glucose and lipid metabolism. Personalized medicine approaches could be key to identify more effective pharmacological strategies as well as to reverse this common and burdensome metabolic liver disease. Finally, metabolomics could be used to identify relevant biomarkers for cancer diagnosis, staging, and prognostication. Cancers of the colon and rectum, breast, prostate, thyroid, and ovaries illustrate the notion that cancer cell metabolic derangements may be utilized in clinical practice. A true personalization of pharmacotherapies should be pursued especially in obese patients with cancer.

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Section: Hypertensionmentioning

confidence: 99%

Section: Hypertensionmentioning

confidence: 99%

Precision medicine approaches in metabolic disorders and target organ damage: where are we now, and where are we going?

Lonardo¹,

Byrne²,

Targher³

2021

MTOD

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“…Thus, different subjects may respond differently to the same antihypertensive treatment and a traditional population-based approach may not be effective. Rather an individualized or personalized approach is required, according to a modern medical model often referred to as “precision medicine” (8).…”

Section: The Patient-centered Model and The Personalization Of Carementioning

confidence: 99%

Connected Health in Hypertension Management

Omboni

2019

Front. Cardiovasc. Med.

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e-health is defined as the use of communication and information technologies (ICT) to manage patients and their health in a more efficient way, with the aim of improving the overall quality of care. Healthcare services relying on telehealth (or telemedicine) and mobile health (m-health) are the most popular e-health tools used by healthcare professionals and consumers. These applications allow the exchange of medical data between patients and their doctors or among healthcare professionals, mainly through the Internet, and are used to provide healthcare services remotely (so-called “ connected health ”). The most popular telemedicine application in the field of hypertension is blood pressure telemonitoring (BPT), which enables transmission of BP and various clinical information from patients' homes or from the community to the doctor's surgery or the hospital. Numerous randomized controlled trials have documented a significant BP reduction combined with an intensification and optimization of the use of antihypertensive medications in patients making use of BPT plus remote counseling by a case manager, with the supervision of a doctor or a community pharmacist (telepharmacy). The major benefits of BPT are usually observed in high-risk patients. BPT can also be based on m-health wireless solutions, provided with educational support, medication trackers and reminders, and teleconsultation. In this context, BPT may favor patient's self-management, as an adjunct to the doctor's intervention, and foster patient's participation in medical decision making, with consequent improvement in BP control and increase in medication adherence. In conclusion, e-health solutions, and in particular telemedicine, are increasingly attaining a key position in the management of the hypertensive patient, with an enormous potential in terms of improvement of the quality of the delivered care, increase in the chance of a successful BP control and effective prevention of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Analysis of Medicinal Provision of Patients With Arterial Hypertension in Hospital Conditions

et al. 2021

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The aim: The aim of the study was to study drug consumption in pharmacotherapy of arterial hypertension in a hospital setting. Materials and methods: In the course of work medical cards of patients of the Kyiv regional Cardiac Dispensary in the conditions of inpatient treatment were used. Methods such as: questionnaire, pharmacoeconomic, expert assessments were used. Results: One of the main issues of drug supply for the population, in particular for patients with arterial hypertension, is the study of the demand and consumption of drugs. The drugs used to treat hypertension belong to different pharmacotherapeutic groups and are used in the treatment of a number of other diseases. Recent years of development of the domestic pharmaceutical market are characterized by an increase in the number of these drugs. Conclusions: One of the main issues of drug supply for the population, in particular for patients with arterial hypertension, is the study of the demand and consumption of drugs. As a result of the study, an analysis of the range of drugs for the treatment of hypertension, a comparative study of the market of offers and prices for the treatment of hypertension was carried out.

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Personalized Medicine and the Treatment of Hypertension

Cited by 32 publications

References 43 publications

Precision medicine approaches in metabolic disorders and target organ damage: where are we now, and where are we going?

Precision medicine approaches in metabolic disorders and target organ damage: where are we now, and where are we going?

Connected Health in Hypertension Management

Analysis of Medicinal Provision of Patients With Arterial Hypertension in Hospital Conditions

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