Personalized Anesthetic Pharmacology

Bach-Rojecky, Lidija; Čutura, Tomislav; Lozić, Marin; Kliškinjić, Ira Husedzinović; Matišić, Vid; Primorac, Dragan

doi:10.1007/978-3-030-53525-4_3

Cited by 6 publications

(4 citation statements)

References 61 publications

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“…Pharmacogenomics (PGx) is the discipline of predicting drug efficacy and toxicity at the genetic level ( 7 ), dedicated to elucidating the genetic variations that underlie the pharmacodynamics and pharmacokinetics of legacy drugs. This knowledge can guide the clinical selection of optimal therapeutic agents at the most appropriate dosage, improving drug efficacy, reducing or avoiding adverse effects, enhancing prognosis, and saving healthcare costs ( 8 ).…”

Section: Genetic Factorsmentioning

confidence: 99%

“…Propofol is the most commonly used parenteral anesthetic with sedative-hypnotic, anxiolytic, anticonvulsant, anti-inflammatory, antiemetic, antioxidant, and possibly neuroprotective effects. Differential responses to propofol may be due to polymorphisms in the gene encoding the metabolic enzyme CYP2B6 ( 7 ). Up to 70% of propofol binds to glucuronide via UGT1A9, while the remaining 30% of the drug is first hydroxylated via CYP2B6 ( 17 ).…”

Section: Genetic Factorsmentioning

confidence: 99%

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Personalized anesthesia and precision medicine: a comprehensive review of genetic factors, artificial intelligence, and patient-specific factors

Zeng,

Qing,

et al. 2024

Front. Med.

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Precision medicine, characterized by the personalized integration of a patient’s genetic blueprint and clinical history, represents a dynamic paradigm in healthcare evolution. The emerging field of personalized anesthesia is at the intersection of genetics and anesthesiology, where anesthetic care will be tailored to an individual’s genetic make-up, comorbidities and patient-specific factors. Genomics and biomarkers can provide more accurate anesthetic protocols, while artificial intelligence can simplify anesthetic procedures and reduce anesthetic risks, and real-time monitoring tools can improve perioperative safety and efficacy. The aim of this paper is to present and summarize the applications of these related fields in anesthesiology by reviewing them, exploring the potential of advanced technologies in the implementation and development of personalized anesthesia, realizing the future integration of new technologies into clinical practice, and promoting multidisciplinary collaboration between anesthesiology and disciplines such as genomics and artificial intelligence.

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Section: Genetic Factorsmentioning

confidence: 99%

Section: Genetic Factorsmentioning

confidence: 99%

Personalized anesthesia and precision medicine: a comprehensive review of genetic factors, artificial intelligence, and patient-specific factors

Zeng,

Qing,

et al. 2024

Front. Med.

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“…Although not commonly prescribed for OA patients, opioid analgesics are a group of drugs most commonly associated with genetic polymorphisms. Tramadol, codeine, and oxycodone are all metabolized by CYP2D6 in the liver and bind to the opioid receptor, both of which have demonstrated the ability to impact the effects and side-effect profile of the drugs [ 49 ]. Another enzyme linked to the effect of opioid analgesics is catechol-O-methyltransferase, which degrades endogenous catecholamines.…”

Section: Peroral Treatmentmentioning

confidence: 99%

“…Another enzyme linked to the effect of opioid analgesics is catechol-O-methyltransferase, which degrades endogenous catecholamines. Its polymorphisms affect the analgesic efficacy of an opioid drug [ 49 ].…”

Section: Peroral Treatmentmentioning

confidence: 99%

Comprehensive Review of Knee Osteoarthritis Pharmacological Treatment and the Latest Professional Societies’ Guidelines

Primorac

Molnar

Matišić³

et al. 2021

Pharmaceuticals

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Osteoarthritis is the most common musculoskeletal progressive disease, with the knee as the most commonly affected joint in the human body. While several new medications are still under research, many symptomatic therapy options, such as analgesics (opioid and non-opioid), nonsteroid anti-inflammatory drugs, symptomatic slow-acting drugs in osteoarthritis, and preparations for topical administration, are being used, with a diverse clinical response and inconsistent conclusions across various professional societies guidelines. The concept of pharmacogenomic-guided therapy, which lies on principles of the right medication for the right patient in the right dose at the right time, can significantly increase the patient’s response to symptom relief therapy in knee osteoarthritis. Corticosteroid intra-articular injections and hyaluronic acid injections provoke numerous discussions and disagreements among different guidelines, even though they are currently used in daily clinical practice. Biological options, such as platelet-rich plasma and mesenchymal stem cell injections, have shown good results in the treatment of osteoarthritis symptoms, greatly increasing the patient’s quality of life, especially when combined with other therapeutic options. Non-inclusion of the latter therapies in the guidelines, and their inconsistent stance on numerous therapy options, requires larger and well-designed studies to examine the true effects of these therapies and update the existing guidelines.

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Pharmacogenomics in Anesthesia

Primorac,

Bach-Rojecky

2023

Pharmacogenomics in Clinical Practice

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Personalized Anesthetic Pharmacology

Cited by 6 publications

References 61 publications

Personalized anesthesia and precision medicine: a comprehensive review of genetic factors, artificial intelligence, and patient-specific factors

Personalized anesthesia and precision medicine: a comprehensive review of genetic factors, artificial intelligence, and patient-specific factors

Comprehensive Review of Knee Osteoarthritis Pharmacological Treatment and the Latest Professional Societies’ Guidelines

Pharmacogenomics in Anesthesia

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