Effective communication is essential if people across the age span are to participate in activities related to language learning, education, employment, interaction with social networks, and medical care (Beukelman & Light, 2020). Interventions for children, youth, and adults with complex communication needs are often personalized depending upon the capabilities of the individual, their environment, and their support systems (Light et al., 2019). Modern augmentative and alternative communication (AAC) technology provides many resources to support personalization of message content and representation. The purpose of this issue is to discuss the personalization of AAC interventions, to illustrate the use of technology to enhance personalization, and to describe the use of such technologies by individuals across the age span, in different environmental situations, and with a range of different language capabilities. In this special issue, authors have been invited to share their knowledge about the personalization of communication supports for children and adults with developmental and acquired language disorders.In the first article, Light et al. ( 2021) describe key principles of early language and literacy intervention for young children with complex communication needs and identify how goals, intervention procedures, AAC supports, and materials were personalized to support the language and literacy development of a young girl with global developmental delays and a severe expressive language delay, in addition to neuromotor and visual dysfunctions.In the second article, Babb et al. (2021) describe a personalized augmentative and alternative intervention for a young adult withThe author has indicated that he has no financial and no nonfinancial relationship to disclose.