Personality Traits of Schizophrenic Patients in Remission and Their First-Degree Relatives: A Dopaminergic and Glutamatergic Gene Polymorphism Study

Altınyazar, Vesile; Günderici, Azad

doi:10.5455/bcp.20130308015536

Cited by 3 publications

(4 citation statements)

References 63 publications

(71 reference statements)

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“…One study did not obtain any association between rs4680 SNPs and schizophrenia 29 , concordant with our results, but another study obtained an association between the val/val genotype and female schizophrenic patients 30 . One meta-analysis reported association between the Val allele and schizophrenia from family-based studies in European populations 7 , but three other meta- Altinyazar V, Gunderici A, Tinaz E, Kirci C analyses did not demonstrate a significant association between rs4680 SNPs and schizophrenia in European and Asian populations 8,9,21 , which is similar to our results. A recent study revealed a strong association of rs4680 and rs165774 in an Australian population 31 .…”

Section: Discussionsupporting

confidence: 89%

“…This COMT enzyme has a central role in the metabolism of dopamine and noradrenaline 6 . The most widely investigated functional polymorphism in the COMT gene is rs4680 [7][8][9][10] . The Val(108/158)Met amino acid exchanges and induces enzyme activity change (approximately 40%) in the brain and lymphocytes 7 .…”

Section: Introductionmentioning

confidence: 99%

“…The most widely investigated functional polymorphism in the COMT gene is rs4680 [7][8][9][10] . The Val(108/158)Met amino acid exchanges and induces enzyme activity change (approximately 40%) in the brain and lymphocytes 7 . Other functional variants independently affecting gene activity in the COMT gene are rs2075507 (previously rs2097603), linked upstream in the P2 promoter, and rs165599 in the 3' untranslated region 11,12 .…”

Section: Introductionmentioning

confidence: 99%

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No association of Catechol-O-Methyltransferase (COMT) Gene Haplotypes in Patients with Schizophrenia in a Turkish Sample

Altınyazar

Günderici

Tınaz

et al. 2015

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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No association of catechol-O-methyltransferase (COMT) gene haplotypes in patients with schizophrenia in a Turkish sample Objective: The dopaminergic system, especially variations in the catechol-O-methyltransferase (COMT) gene, is of major interest in the etiology of schizophrenia. The rs4680 (Val108/158Met), rs165599, and P2 promoter rs2075507 single nucleotide polymorphisms (SNPs) in the COMT gene have been shown to be associated with alteration of COMT gene expression and COMT enzyme activity. The aim of this study was to investigate a possible association between schizophrenia and the haplotypes of these polymorphisms. Methods: The sample was comprised of 181 patients with schizophrenia and 368 healthy controls. The patients' psychotic symptoms were rated using the Positive and Negative Symptom Scale (PANSS). COMT rs2075507, rs4680, and rs165599 SNPs were evaluated by a polymerase chain reaction, followed by restriction fragment length polymorphism analysis. These SNPs in the COMT gene were subjected to haplotype analyses using Haploview ver. 4.2. Results: No significant differences were found between COMT rs2075507, rs4680, and rs165599 SNPs in schizophrenic patients and controls. The patients' PANSS results were not associated with these SNPs. No associations were obtained between 2 and 3-haplotypes of rs2075507, rs4680, rs165599 SNPs and schizophrenia. Conclusion: COMT rs2075507, rs4680, rs165599 SNPs and haplotypes do not appear to be risk factors for schizophrenia in this population.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No association of Catechol-O-Methyltransferase (COMT) Gene Haplotypes in Patients with Schizophrenia in a Turkish Sample

Altınyazar

Günderici

Tınaz

et al. 2015

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…In path analyses HA and ST turned out to be associated with both cognitive biases and SD. These traits have consistently been reported to be elevated in patients with schizophrenia [84][85][86][87][88][89][90] (also in remission [91]), their first-degree relatives with schizotypal features [92], UHR individuals [49] and in non-clinical samples where it correlated with schizotypal traits [93,94]. With regard to HA, there is evidence that this personality feature may be considered a schizophrenia-related endophenotype marker [86,88,95].…”

Section: Discussionmentioning

confidence: 97%

Integrating trauma, self-disturbances, cognitive biases, and personality into a model for the risk of psychosis: a longitudinal study in a non-clinical sample

Pionke-Ubych

Frydecka

Cechnicki

et al. 2021

Eur Arch Psychiatry Clin Neurosci

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The hypothesis of the psychosis continuum enables to study the mechanisms of psychosis risk not only in clinical samples but in non-clinical as well. The aim of this longitudinal study was to investigate self-disturbances (SD), a risk factor that has attracted substantial interest over the last two decades, in combination with trauma, cognitive biases and personality, and to test whether SD are associated with subclinical positive symptoms (PS) over a 12-month follow-up period. Our study was conducted in a non-clinical sample of 139 Polish young adults (81 females, age M = 25.32, SD = 4.51) who were selected for frequent experience of subclinical PS. Participants completed self-report questionnaires for the evaluation of SD (IPASE), trauma (CECA.Q), cognitive biases (DACOBS) and personality (TCI), and were interviewed for subclinical PS (CAARMS). SD and subclinical PS were re-assessed 12 months after baseline measurement. The hypothesized model for psychosis risk was tested using path analysis. The change in SD and subclinical PS over the 12-month period was investigated with non-parametric equivalent of dependent sample t-tests. The models with self-transcendence (ST) and harm avoidance (HA) as personality variables were found to be well-fitted and explained 34% of the variance in subclinical PS at follow-up. Moreover, we found a significant reduction of SD and subclinical PS after 12 months. Our study suggests that combining trauma, cognitive biases, SD and personality traits such as ST and HA into one model can enhance our understanding of appearance as well as maintenance of subclinical PS.

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Disintegration as an Additional Trait in the Psychobiological Model of Personality

Lazarević

Bošnjak

Knežević

et al. 2016

Zeitschrift für Psychologie

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Abstract. This meta-analytic study investigates the relations between Disintegration-like phenomena (i.e., various aspects of symptomatology with the prefix “schizo-,” both at the clinical and the subclinical level) and the traits of the Psychobiological Model of Personality (PBMP). The empirically based benchmark for assuming the distinctness of the trait Disintegration was .30. The sample included 26 manuscripts with 30 studies and 424 effect sizes. By computing inverse sampling variance weighted mean correlation coefficients under a random-effects assumption, the following associations were found between Disintegration and Harm Avoidance, Novelty Seeking, Reward Dependence, Persistence, Self-Directedness, Cooperativeness, and Self-Transcendence: .23, .04, −.15, −.02, −.23, −.16, and .17, respectively. Two variables were found to moderate the Disintegration-Self-Transcendence correlation. Despite the theoretical expectation and some empirical evidence that Self-Transcendence (and other character traits) should capture variations in Disintegration-like phenomena, our results suggest that schizo-type phenomena are not adequately covered by the PBMP.

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Personality Traits of Schizophrenic Patients in Remission and Their First-Degree Relatives: A Dopaminergic and Glutamatergic Gene Polymorphism Study

Cited by 3 publications

References 63 publications

No association of Catechol-O-Methyltransferase (COMT) Gene Haplotypes in Patients with Schizophrenia in a Turkish Sample

No association of Catechol-O-Methyltransferase (COMT) Gene Haplotypes in Patients with Schizophrenia in a Turkish Sample

Integrating trauma, self-disturbances, cognitive biases, and personality into a model for the risk of psychosis: a longitudinal study in a non-clinical sample

Disintegration as an Additional Trait in the Psychobiological Model of Personality

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