Personality traits of aggression-submissiveness and perfectionism associate with ABO blood groups through catecholamine activities

Hobgood, Donna K.

doi:10.1016/j.mehy.2011.04.039

Cited by 13 publications

(20 citation statements)

References 77 publications

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“…In this study, we investigated possible associations between ABO phenotype and genotype and personality traits based on Hobgood’s hypothesis [ 22 ][ 23 ]. The results of this study showed significant differences in Persistence scores according to both genotype and phenotype.…”

Section: Discussionmentioning

confidence: 99%

“…However, a scientific hypothesis concerning ABO blood groups and personality traits was recently proposed by Hobgood [ 22 ][ 23 ]. Dopamine beta-hydroxylase (DBH) is known to catalyze the conversion of dopamine to norepinephrine, and the DBH gene is in tight linkage with the ABO gene on chromosome 9q34 [ 24 ][ 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…The ABO group B marker rs8176746 and the low-activity DBH allele rs1611115T exhibit similar frequency distributions among HapMap populations. For these reasons, and considering the known effects of catecholamine on behavior, Hobgood [ 22 ][ 23 ] suggested that linkage between DBH and ABO may explain the associations between personality traits and ABO blood type.…”

Section: Introductionmentioning

confidence: 99%

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ABO Blood Type and Personality Traits in Healthy Japanese Subjects

et al. 2015

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There is no scientific consensus that a relationship exists between the ABO blood group and personality traits. However, a recent study hypothesized that the dopamine beta-hydroxylase (DBH) gene is in linkage with the ABO gene. The sample population consisted of 1,427 healthy Japanese subjects who completed the Temperament and Character Inventory (TCI). Each subject’s ABO blood type was determined by genotyping the rs8176719 and rs8176746 ABO gene single-nucleotide polymorphisms (SNPs) using a TaqMan genotyping assay. The relationships between the six ABO genotypes or four ABO phenotypes and personality traits were examined using a multivariate analysis of covariance (MANCOVA), controlling for age and sex. The MANCOVA data showed a significant difference in TCI scores among the ABO genotype groups (F [7, 1393] = 3.354, p = 0.001). A subsequent univariate analysis showed a significant difference in the mean scores for Persistence among the genotype groups (F = 2.680, partial η2 = 0.010, p = 0.020). Similarly, dividing the ABO blood type into four phenotypes revealed a significant difference among the phenotype groups (F [7, 1397] = 2.529, p = 0.014). A subsequent univariate analysis showed a significant difference among the phenotype groups in the mean scores for Persistence (F = 2.952, partial η2= 0.006, p = 0.032). We observed a significant association between ABO blood group genotypes and personality traits in a large number of healthy Japanese subjects. However, these results should be regarded as preliminary and should be interpreted with caution because it is possible that the association between ABO blood group genotype and the Persistence trait is relatively weak.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ABO Blood Type and Personality Traits in Healthy Japanese Subjects

et al. 2015

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“…B phenotype was correlated with submissiveness, perfectionism, and nonaggressiveness on the basis of the level of catecholamine. With the same reasons, blood type O was correlated with nonsubmissiveness, non-perfectionism, and aggressiveness (Hobgood, 2011).…”

Section: Personality Traitsmentioning

confidence: 84%

“…Therefore, ABO blood group may affect the human's traits and habits. Hobgood investigated the possible link between blood groups and personality traits (Hobgood., 2011). The author hypothesized that personality traits were correlated with catecholamine genes.…”

Section: Personality Traitsmentioning

confidence: 99%

An update on susceptibility of individuals to diseases based on ABO blood groups

Obeagu¹

2019

Int. J. Curr. Res. Med. Sci.

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Blood groups are phenotypic expression of the antigen present mainly in the red cells and some body fluids of an individual using corresponding antibody. ABO was the first set of blood group discovered and shows the highest clinical relevance in blood transfusion medicine. Researchers are concerned with ways of making life better for mankind and continue to look for improved methods of doing things. There is a strong relationship between the ABO blood group and some diseases. This paper was written to update the world on the association of ABO blood groups to susceptibility to some diseases.

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ACE inhibitors could be therapeutic for antisocial personality disorder

Hobgood

2013

Medical Hypotheses

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Antisocial personality traits are an important topic for research. The societal cost of these behaviors encourages efforts at a better understanding of central nervous system causes. Catecholamine genes are being studied to facilitate this understanding, and some tentative findings are being reached about several of these genes. It seems that many genes play a role to produce antisocial behaviors so complexity of elucidating each gene is obvious. One conclusion that could be drawn from the current research findings is that DA2 like receptors (DRD2, DRD3, DRD4) with alleles that decrease neurotransmission are facilitatory of antisocial behaviors. DA2 like receptors cause neuronal firing to inhibit many peripheral functions through adenylyl cyclase inhibition. When these receptors are less active by genetically decreased density, lower affinity, or by low dopamine levels as final common pathways then inhibition is released and a state of disinhibition can be said to describe this state. Peripheral metabolism is increased and behavioral activation is noted. Renin is disinhibited in this setting thus allowing sympathetic nervous system activation. The fight or flight behaviors thus produced, in the extreme, would be the setting of antisocial behavior. Research validates this hypothesis. Understanding this final common pathway toward antisocial behavior should lead to better treatment for individuals with this pattern of behavior before they have caused harm to themselves and others. ACE inhibitors are well tolerated drugs used in the treatment of hypertension and heart failure and would also treat antisocial behavior disorders.

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Personality traits of aggression-submissiveness and perfectionism associate with ABO blood groups through catecholamine activities

Cited by 13 publications

References 77 publications

ABO Blood Type and Personality Traits in Healthy Japanese Subjects

ABO Blood Type and Personality Traits in Healthy Japanese Subjects

An update on susceptibility of individuals to diseases based on ABO blood groups

ACE inhibitors could be therapeutic for antisocial personality disorder

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