Personality traits in subjects at risk for unipolar major depression: A family study perspective

Maier, Wolfgang; Lichtermann, Dirk; Minges, Jürgen; Heun, Reinhard

doi:10.1016/0165-0327(92)90063-c

Cited by 94 publications

(35 citation statements)

References 19 publications

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“…This would predict higher N in the relatives of subjects with MD who themselves have never had a depressive episode. Several studies have demonstrated that the healthy relatives of depressed probands had higher N scores than healthy relatives of controls (Wetzel et al, 1980;Krieg et al, 1990;Maier et al, 1992;Lauer et al, 1997). Family studies, however, cannot truly test hypotheses about genetic factors shared between two traits.…”

Section: Neuroticism and Major Depressionmentioning

confidence: 94%

The genetic relationship of personality to major depression and schizophrenia

Fanous

Kendler

2004

neurotox res

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Since ancient times, dimensions of personality have been linked with the liability to psychiatric illness. In modern times, several research approaches suggest that personality and the liability to psychiatric illness such as schizophrenia and major depression (MD) are influenced by many of the same genes. If this is true, it could shed light on the genetic architecture of psychiatric illness. It could also validate the use of personality measures in unaffected relatives in linkage and association studies of psychiatric illness. This approach could potentially increase statistical power to detect genetic effects. The personality trait neuroticism (N) may be genetically related to MD, while schizotypal traits may be genetically related to schizophrenia. Twin studies have reported that most of the covariation between N and MD is due to shared additive genetic factors. Adoption studies have demonstrated that the biological offspring of schizophrenic mothers are more likely to have schizotypal personality disorder than are children of control mothers. At the current time, only one genome wide scan of N has been published, which does show some overlap in linkage results with genome scans of MD. However, this should be replicated and more rigorously studied. At the present time, there are no established susceptibility genes for MD. When these are established, it will be necessary to assess their relationship with N. Currently, no genome scans of schizotypy have been published. Furthermore, although several putative susceptibility genes for schizophrenia have been reported and replicated, only one--catechol-O-methyltransferase (COMT)--has been tested in schizotypy.

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Section: Neuroticism and Major Depressionmentioning

confidence: 94%

The genetic relationship of personality to major depression and schizophrenia

Fanous

Kendler

2004

neurotox res

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“…This alternative dimension, which was based on descriptions of personality deviance (unrelated to E or N; see later) that might occur prior to the onset of schizophrenia or among biological relatives of schizophrenic patients (e.g., Slater, 1953), was termed S or Insensitivity. Subsequently, the inverse of the EPQ P factor was found to include a separate dimension, called G or Orderliness, which, according to Tellenbach (1961), Maier, Lichtermann, Minges, and Heun (1992), and other investigators, appeared to describe a single component of the premorbid personality configuration (also characterized by high N) that determines the probability of being affected by unipolar depression and, perhaps, bipolar disorder (Van Kampen, 1997). Indeed, recent research by Sakai et al (2009) has very much elucidated the causal role played by this and similar dimensions in the onset of depressive symptoms.…”

mentioning

confidence: 99%

The 5-Dimensional Personality Test (5DPT): Relationships With Two Lexically Based Instruments and the Validation of the Absorption Scale

Kampen

2012

Journal of Personality Assessment

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“…According to Angst and Clayton (1986) unipolar depressives scored high in aggression and autonomic lability. Elevated levels of autonomic lability or of neuroticism were also found by Maier et al (1992), Rorsman et al (1993), Kendler et al (1993), Clayton et al (1994), Lauer et al (1997), Surtees and Wainwright (1996), and Boyce et al (1991). In addition to this personality trait, Maier et al (1992) found elevated levels of rigidity and lowered levels of extraversion and frustration tolerance.…”

mentioning

confidence: 64%