Personality traits and the development of nicotine, alcohol, and illicit drug disorders: Prospective links from adolescence to young adulthood.

Elkins, Irene J.; King, Serena M.; Iacono, William G.

doi:10.1037/0021-843x.115.1.26

Cited by 197 publications

(149 citation statements)

References 67 publications

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“…The BD liability is expressed as different phenotypes over the course of development with the same early temperament traits predicting various subsequent EXT disorders. Behavioral disinhibition traits, such as lack of inhibitory control, novelty seeking, and low harm avoidance, when expressed during early childhood predict subsequent substance use and misuse during adolescence (Caspi, Henry, McGee, Moffitt, & Silva, 1995;Caspi et al, 1996;Masse & Tremblay, 1997;Wong et al, 2006), and the same traits assessed during late childhood, adolescence, and young adulthood predict tobacco, alcohol, and illicit drug symptoms and disorders in later in adulthood (Chassin, Fora, & King, 2004;Cloninger, Sigvardsson, & Bohman, 1988;Elkins et al, 2006;Grekin, Sher, & Wood, 2006;Krueger, 1999a;Sher, Bartholow, & Wood, 2000). These traits also manifest as disruptive behavior disorders (e.g., Oppositional Defiant Disorder, CD) during childhood (Young, et al, 2009), which are predictive of later SUDs (Kim-Cohen et al, 2003;Weinberg, Rahdert, Colliver, & Glantz, 1998), and as high-risk behaviors during early adolescence, such as antisocial behavior, experimentation with alcohol, precocious sexual activity, and academic difficulty, which in turn predict later SUDs and ASPD (Grant & Dawson, 1997;.…”

Section: Behavioral Disinhibition Liability For Externalizing Disordersmentioning

confidence: 99%

An Integrative Common Liabilities Model for the Comorbidity of Substance Use Disorders with Externalizing and Internalizing Disorders

Tully

Iacono

2014

Oxford Handbooks Online

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This paper presents an integrative research-derived model to explain comorbidity among SUDs, externalizing disorders, and internalizing disorders. This hierarchical model is based on phenotypic covariance among the disorders and latent common genetic liability. At the highest level of the hierarchy, general genetically-influenced biological dispositions to negative emotionality and behavioral disinhibition each give rise to spectra of related personality traits, cognitive processes, behavioral tendencies, and psychopathology that account for the pattern of co-occurrence among mental disorders. At the lowest level of the hierarchy, disorder-specific genetic and environmental effects explain the presence of some and not other disorders associated with a given general liability. Interplay between the general liabilities and both other genes and environmental factors throughout development affect the likelihood of developing specific mental disorders.

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Section: Behavioral Disinhibition Liability For Externalizing Disordersmentioning

confidence: 99%

An Integrative Common Liabilities Model for the Comorbidity of Substance Use Disorders with Externalizing and Internalizing Disorders

Tully

Iacono

2014

Oxford Handbooks Online

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“…We only consider prospective studies of adolescents that restricted their analyses to samples of smokers to ensure that predictors are unique to dependence and do not characterize smoking more generally. Thus, we do not review studies where those dependent were compared to all those not dependent, including subjects who never smoked (Elkins et al, 2006;Fergusson et al, 1996;Patton et al, 2005).…”

Section: Correlates and Predictors Of Nicotine Dependencementioning

confidence: 99%

On the development of nicotine dependence in adolescence

Kandel

Griesler

et al. 2007

Drug and Alcohol Dependence

181

177

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Little is known about the natural history of drug dependence. This article describes the development and predictors of DSM-IV nicotine dependence in adolescence when tobacco use is initiated. In a two-stage design, a survey was administered to 6th-10th graders in the Chicago Public Schools to select a cohort of adolescents. Household interviews were conducted with adolescents five times and with one parent (predominantly mothers) three times over two years. The analytical sample includes 353 youths, who started using tobacco within 12 months preceding Wave 1 or between Waves 1-5. Survival analysis estimated latency to individual DSM-IV nicotine dependence criteria and the full dependence syndrome. Twenty-five percent of youths experienced the syndrome within 23 months of tobacco use onset. Tolerance, impaired control and withdrawal were experienced most frequently. Youths who experienced full dependence experienced their first symptom faster after tobacco use onset than those who experienced only one criterion through the end of the observation period. Cox proportional hazards models estimated the importance of time-constant and time-varying sociodemographic, tobacco and other drug use, parental and peer smoking, social psychological and biological risk factors for experiencing the first criterion and the full syndrome. Pleasant initial sensitivity to tobacco and number of cigarettes smoked the prior month predicted both outcomes. Parental dependence predicted the full syndrome. Significant covariates were generally the same across gender and racial/ethnic subgroups. The predictive significance of the initial smoking experience and parental dependence highlight the potential importance of genetic factors in the etiology of nicotine dependence.

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“…There has been limited sample attrition over the successive waves of assessments, with from 80-93% of surviving twins participating at each follow-up assessment. For example, Elkins et al (2006) report that in the older cohort 83% of males and 93% of females from the older cohort completed their first follow-up assessment, while reported that 92% of males and 94% of females from the younger cohort completed their first follow-up assessment. Importantly, in all cases non-participants differ minimally, although in some cases significantly, from participants in terms of their status on the intake assessments.…”

Section: Samplementioning

confidence: 99%

The adolescent origins of substance use disorders

McGue

Iacono

2008

Int. J. Methods Psychiatr. Res.

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Although early use of alcohol during adolescence has been consistently associated with increased risk of alcoholism in adulthood, the specific mechanisms that underlie this association remain unclear. We describe a program of epidemiological twin-family research that shows that early use of alcohol is best conceptualized as an indicator of a more general propensity to engage in adolescent problem behavior. Adolescent problem behavior, in turn, is a risk factor for a broad range of adult externalizing disorders, of which alcoholism is but one manifestation. These findings are shown to be consistent with a dual-process model whereby early adolescent problem behavior is associated with increased risk of adult psychopathology because both are indicators of a common inherited liability and because early adolescent problem behavior increases the likelihood an adolescent is exposed to high-risk environments. We conclude with a discussion of the importance of cross-cultural research, which may be especially informative for identifying the consequences of early adolescent drinking.Keywords adolescent drinking; disinhibitory psychopathology; adolescent problem behavior; cross-cultural alcohol researchOne of the most robust findings in the alcohol research field is the association between an early initiation of alcohol use and risk of alcohol dependence. In a highly cited influential study on a large US epidemiological sample, Grant and Dawson (1997) reported that individuals who retrospectively report that they had first tried alcohol prior to age 15 were four times more likely to have a lifetime diagnosis of alcohol dependence than individuals you first tried alcohol after the age of 20. This finding has been replicated in several retrospective studies (Dewit et al., 2000;Hingson et al., 2006;McGue et al., 2001a;Prescott and Kendler, 1999) and at least one prospective study (Keyes et al., 2006). Unfortunately, however, all of these studies have been based on US samples, an important limitation to which we will return later.The consistency and strength of the association between early alcohol use and alcoholism suggest that it has implications for efforts to prevent alcoholism onset. The nature of these implications, however, necessarily depends on the specific mechanisms that underlie the association. Two alternative mechanisms have been proposed. First, early use of alcohol may increase alcoholism risk by altering the course of adolescent development (Dewit et al., 2000). Adolescent alcohol use could alter the course of development by decreasing the Alternatively, others have suggested that the association of early alcohol use with alcoholism risk is spurious, arising because early use of alcohol in adolescence and alcoholism in adulthood are both manifestations of a general inherited liability to disinhibitory psychopathology Young et al., 2000). Support for this proposition came initially from a study of nearly 9000 twins, which showed that early use of alcohol was heritable and its association with alcoholism...

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Personality traits and the development of nicotine, alcohol, and illicit drug disorders: Prospective links from adolescence to young adulthood.

Cited by 197 publications

References 67 publications

An Integrative Common Liabilities Model for the Comorbidity of Substance Use Disorders with Externalizing and Internalizing Disorders

An Integrative Common Liabilities Model for the Comorbidity of Substance Use Disorders with Externalizing and Internalizing Disorders

On the development of nicotine dependence in adolescence

The adolescent origins of substance use disorders

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