Personality features in ultra-high risk for psychosis: A comparative study with schizophrenia and control subjects using the Temperament and Character Inventory-Revised (TCI-R)

Fresán, Ana; León-Ortíz, Pablo; Robles-García, Rebeca; Azcárraga, Mariana; Guízar, Diana; Reyes-Madrigal, Francisco; Tovilla-Zárate, Carlos Alfonso; Fuente‐Sandoval, Camilo de la

doi:10.1016/j.jpsychires.2014.12.013

Cited by 38 publications

(33 citation statements)

References 53 publications

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“…Several studies have found an association between affective or overall empathy and negative symptoms (Bora et al, 2008;Kucharska-Pietura et al, 2012;Lincoln et al, 2011;Shamay-Tsoory et al, 2007;Smith et al, 2014;Sparks et al, 2010); associations have also been found with positive symptoms (Konstantakopoulos et al, 2014;Lysaker et al, 2013;Smith et al, 2014;Sparks et al, 2010), depression (Abramowitz et al, 2014;Didehbani et al, 2012;Horan et al, 2015), anxiety (Achim et al, 2011), and insight (Didehbani et al, 2012;Lysaker et al, 2013;Pijnenborg et al, 2013). However, though several studies report significant relationships with symptoms, as many studies have reported no association (Corbera et al, 2013;Derntl et al, 2012a;Derntl et al, 2012b;Fresán et al, 2015;Fujino et al, 2014;Fujiwara et al, 2008;Lam et al, 2014;Lehmann et al, 2014;McCormick et al, 2012;Montag et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Affective empathy in schizophrenia: a meta-analysis

Bonfils

Lysaker²,

Minor

et al. 2016

Schizophrenia Research

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Section: Discussionmentioning

confidence: 99%

Affective empathy in schizophrenia: a meta-analysis

Bonfils

Lysaker²,

Minor

et al. 2016

Schizophrenia Research

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“…Subjects scoring high in harm avoidance are described as rather worrying, fearful, shy, and fatigable (Cloninger et al, 1993). Several studies found elevated harm avoidance scores in schizophrenia patients (Jetha et al, 2013;Ohi et al, 2012) and subjects at ultra-high risk for psychosis or experiencing psychotic-like symptoms (Fresán et al, 2015;Nitzburg et al, 2014). With regard to bipolar disorder, harm avoidance was associated with mood episode recurrence in bipolar offspring in a longitudinal study (Kemner et al, 2015) and with the overall burden of depressive episodes during lifetime in a sample of bipolar (I and II) and unipolar patients (Zaninotto et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System

Trost

Diekhof

Mohr

et al. 2016

Neuropsychopharmacol

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Recent genome-wide association studies have identified MAD1L1 (mitotic arrest deficient-like 1) as a susceptibility gene for bipolar disorder and schizophrenia. The minor allele of the single-nucleotide polymorphism (SNP) rs11764590 in MAD1L1 was associated with bipolar disorder. Both diseases, bipolar disorder and schizophrenia, are linked to functional alterations in the reward system. We aimed at investigating possible effects of the MAD1L1 rs11764590 risk allele on reward systems functioning in healthy adults. A large homogenous sample of 224 young (aged 18-31 years) participants was genotyped and underwent functional magnetic resonance imaging (fMRI). All participants performed the 'Desire-Reason Dilemma' paradigm investigating the neural correlates that underlie reward processing and active reward dismissal in favor of a long-term goal. We found significant hypoactivations of the ventral tegmental area (VTA), the bilateral striatum and bilateral frontal and parietal cortices in response to conditioned reward stimuli in the risk allele carriers compared with major allele carriers. In the dilemma situation, functional connectivity between prefrontal brain regions and the ventral striatum was significantly diminished in the risk allele carriers. Healthy risk allele carriers showed a significant deficit of their bottom-up response to conditioned reward stimuli in the bilateral VTA and striatum. Furthermore, functional connectivity between the ventral striatum and prefrontal areas exerting top-down control on the mesolimbic reward system was reduced in this group. Similar alterations in reward processing and disturbances of prefrontal control mechanisms on mesolimbic brain circuits have also been reported in bipolar disorder and schizophrenia. Together, these findings suggest the existence of an intermediate phenotype associated with MAD1L1.

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“…Some studies have established a lower score in NS and PS, 36,37 but the most studies have not found statistically significant differences in comparison with the healthy controls. [38][39][40][41] In the character traits such as cooperativeness (CO) and self-directedness (SD), patients with schizophrenia had lower scores, and in self-transcendence (ST), patients with schizophrenia had higher scores compared to controls in some studies. 37,42,43 As shown earlier, many factors were investigated before, but little is known about the interactions of these factors.…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of Schizophrenia and Social Phobia – Impact on Quality of Life, Hope, and Personality Traits: A Cross-sectional Study

Vrbová¹

2018

Preprint

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Objective: The purpose of the study was to explore whether the comorbidity of social phobia affects symptoms severity, positive and negative symptoms, self-stigma, hope, and quality of life in patients with schizophrenia spectrum disorders. Methods: This is a cross-sectional study in which all participants completed the Internalized Stigma of Mental Illness (ISMI) scale, Adult Dispositional Hope Scale (ADHS), Liebowitz Social Anxiety Scale (LSAS), Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), Positive and Negative Syndrome Scale (PANSS), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Temperament and Character Inventory-Revised (TCI-R), and the demographic questionnaire. The disorder severity was assessed both by a psychiatrist (Clinical Global Impression Severity-the objective version [objCGI-S] scale) and by the patients (Clinical Global Impression Severity-the subjective version [subjCGI-S] scale). The patients were in a stabilized state that did not require changes in the treatment. Diagnosis of schizophrenia, schizoaffective disorder, or delusional disorder was determined according to the International Classification of Diseases 10th Revision (ICD-10) research criteria. A structured interview by Mini International Neuropsychiatric Interview was used to confirm the diagnosis. Results: The study included 61 patients of both genders. Clinically, the patients with comorbid social phobia had the earlier onset of the illness, more severe current psychopathology, more intense anxiety (general and social), and higher severity of depressive symptoms. The patients with comorbid social phobia showed the significantly lower quality of life compared to the patients without this comorbidity. The patients with comorbid social phobia also had a statistically lower mean level of hope and experienced a higher rate of the self-stigma. They also exhibited higher average scores of personality trait harm avoidance (HA) and a lower score of personality trait self-directedness (SD). Conclusion: The study demonstrated differences in demographic factors, the severity of the disorder, self-stigma, hope, HA, and SD between patients with schizophrenia spectrum disorders with and without comorbid social phobia.

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Personality features in ultra-high risk for psychosis: A comparative study with schizophrenia and control subjects using the Temperament and Character Inventory-Revised (TCI-R)

Cited by 38 publications

References 53 publications

Affective empathy in schizophrenia: a meta-analysis

Affective empathy in schizophrenia: a meta-analysis

Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System

Comorbidity of Schizophrenia and Social Phobia – Impact on Quality of Life, Hope, and Personality Traits: A Cross-sectional Study

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