Personality disorder comorbidity among patients with bipolar I disorder in remission

Abstract

The results of this study suggest that comorbid personality disorder might alter the course of BD and result in a poorer prognosis and more severe psychopathology. Further prospective controlled studies minimizing the bias of interviewers and other confounding factors would help us to understand the pure impact of personality disorder on the course of BD, its prognosis and response to treatment.

Comorbid personality disorders in subjects with bipolar I disorder

“…Similar results have been reported in four studies conducted in Europe [4,5,22,25]. One might speculate that social factors such as cultural differences between different societies (e.g., Turkey or Europe versus North America) from which the result stem may have exerted an influence, but we are not aware of any empirical study testing such a hypothesis adequately.…”

“…It appears that comorbid personality disorder occurs in more than half of the subject with bipolar I disorder (57%). This prevalence rate is comparable with rates found in other studies that used structured interviews [4,5,12,20,21]. In two of the recent studies with similar methodology and sample structure, Tamam et al [5] found that 62% of bipolar I patients in remission have at least one comorbid personality disorder, whereas Ucok et al [6] reported a personality disorder comorbidity rate of 48% among euthymic bipolar I patients.…”

“…It has been suggested that personality disorders could lead patients to be more vulnerable to affective disorders [5,24].…”

A comparison of the medical lethality of suicide attempts in bipolar and major depressive disorders

“…As an example, Tamam et al. (36) found that 20.3% of subjects with BPD I in remission had a comorbid Cluster B diagnosis. However, Tamam et al.…”

The clinical management of bipolar disorder complexity using a stratified model

“…In a recent World Mental Health Survey Initiative, 88% of BD-I, 83% of BD-II, and 69% of subthreshold BD patients reported having at least one other DSM-IV psychiatric disorder (8). Other commonly occurring comorbidities that can obfuscate diagnosis, complicate treatment, and contribute to a poorer prognosis of BD include eating disorders (105,106), personality disorders (107)(108)(109), and physical illnesses (110,111). Other commonly occurring comorbidities that can obfuscate diagnosis, complicate treatment, and contribute to a poorer prognosis of BD include eating disorders (105,106), personality disorders (107)(108)(109), and physical illnesses (110,111).…”