Personality Dimensions Are Associated with Quality of Life in Fluctuating Parkinson’s Disease Patients (PSYCHO-STIM)

Abstract

Background: Parkinson's disease (PD) negatively affects patients' Quality of Life (QoL) which depends on both objective criteria such as physical health and subjective ones such as worries and norms according to personal believes. Therefore, QoL could be also associated to personality dimensions in chronic neurological diseases such as PD. Objective: Our objective was thus to study the potential association between personality dimensions and QoL in PD patients with motor fluctuations before Deep Brain Stimulation of the Sub-Thalamic Nucleus (DBS-STN). Methods: Data were obtained from the French multicentric cohort study Predi-Stim. All PD patients awaiting DBS-STN and responding to the inclusion criteria at the time of the study were included. All participants answered the "Temperament and Character Inventory" (TCI) and the PDQ-39 before surgery. Analyses were made using adjusted univariate generalized linear regression models to evaluate a potential association between TCI dimensions and PDQ-39 scores. Results: Three hundred thirty-three consecutive patients were included. The temperament Harm Avoidance was negatively associated with QoL (p = 1e-4, R 2 = 0.33), whereas the character Self-Directedness was positively associated with mental component of QoL (p = 2e-4, R 2 = 0.33) in PD patients with motor fluctuations awaiting DBS-STN. Conclusions: PD patients with motor fluctuations, with lower Harm Avoidance and higher Self-Directedness scores have the best QoL mainly at an emotional and social level. Therapeutic education of these PD patients focusing on their personal resources may thus be important to improve their well-being.

Quality of Life of Prostate Cancer Patients Undergoing Prostatectomy and Affective Temperament

“…There is a paucity of literature on affective temperament types in cancer patients, and it remains undetermined whether and to what extent affective temperament is linked to QoL in cancer survivors. Relationships between temperamental traits and the course of the disease and QoL were previously described for various disease entities including metabolic syndrome, 19 psoriasis, 20 Parkinson’s disease, 21 post-traumatic stress disorder, 22 and breast cancer. 23 However, these studies were based on different definitions and scales of QoL and temperament.…”

Personality and quality-of-life improvement after apomorphine infusion in Parkinson’s disease

“…The protocol can be found in our previous study. 14 Matching with PwPD awaiting CSAI was done according to age, disease duration and sex. When a ‘perfect match’ was not available, we prioritized age and sex for matching, followed by only age andonly disease duration.…”

“…The secondary objectives were to determine associations between TCI personality dimensions and QoL before starting CSAI treatment and to compare personality dimensions of PwPD awaiting CSAI to those awaiting DBS-STN from the PREDI-STIM study. 14 …”

“… 12 Hence, personality was shown to be associated with health-related QoL in different studies, 13 as previously reported in Parkinson’s disease. 14 In this respect, personality could be an interesting factor for predicting QoL improvement after CSAI, as it was associated with QoL improvement after DBS-STN 15 using the Temperament and Character Inventory (TCI) (validated in a large cohort of PwPD 16 ), which provides a quantitative measure of seven personality dimensions. 17 …”