Personality, Coping Style, and Constitutional Neuroimmunology

Zozulya, A. A.; Gabaeva, M. V.; Sokolov, O. Yu.; Surkina, Ida D; Кост, Н. В.

doi:10.1080/15476910802131444

Cited by 57 publications

(38 citation statements)

References 45 publications

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“…In humans and primates, traumatic experiences often increase the risk for psychopathology but in some conditions, they can lead to resilience (Lyons and Parker, 2007), a form of active coping when faced with a challenging environment, later in life (Zozulya et al, 2008). Similarly in rodents, successful adaptation after exposure to chronic stress in early life has been observed, and has been associated with changes in the HPA axis (Franklin et al, 2011;Gapp et al, 2014b;Uchida et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Potential of Environmental Enrichment to Prevent Transgenerational Effects of Paternal Trauma

Gapp

Bohacek

Grossmann

et al. 2016

Neuropsychopharmacol

146

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Adverse experiences in early life are risk factors for the development of behavioral and physiological symptoms that can lead to psychiatric and cognitive disorders later in life. Some of these symptoms can be transmitted to the offspring, in some cases by non-genomic mechanisms involving germ cells. Using a mouse model of unpredictable maternal separation and maternal stress, we show that postnatal trauma alters coping behaviors in adverse conditions in exposed males when adult and in their adult male progeny. The behavioral changes are accompanied by increased glucocorticoid receptor (GR) expression and decreased DNA methylation of the GR promoter in the hippocampus. DNA methylation is also decreased in sperm cells of exposed males when adult. Transgenerational transmission of behavioral symptoms is prevented by paternal environmental enrichment, an effect associated with the reversal of alterations in GR gene expression and DNA methylation in the hippocampus of the male offspring. These findings highlight the influence of both negative and positive environmental factors on behavior across generations and the plasticity of the epigenome across life.

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Section: Discussionmentioning

confidence: 99%

Potential of Environmental Enrichment to Prevent Transgenerational Effects of Paternal Trauma

Gapp

Bohacek

Grossmann

et al. 2016

Neuropsychopharmacol

146

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“…Physiological-behavioral trait associations are commonly referred to as stress coping styles [Koolhaas et al, 1999], while consistent individual variations in behavior across situations have been denoted behavioral syndromes [Sih et al, 2004a, b], animal personalities [Gosling, 2001], temperament [Réale et al, 2007], or a shyness-boldness continuum [Wilson et al, 1994;Sneddon, 2003]. Despite a certain lack of consensus in terminology, revealing the ultimate and proximate mechanisms behind these analogues of human personality may add to the knowledge within diverse fields such as evolutionary ecology, animal husbandry, and biomedicine [Korte et al, 2005;Øverli et al, 2007;Zozulya et al, 2008;Dingemanse and Wolf, 2010;Koolhaas et al, 2010;Stamps and Groothuis, 2010;Conrad et al, 2011;Castanheira et al, 2015;Duckworth, 2015;Hau and Goymann, 2015;Sih et al, 2015]. Among the questions raised are: via what mechanisms are trait correlations inherited, which circumstances benefit different complex phenotypes, and what are the costs and benefits of the limited plasticity imposed by fixed trait associations?…”

Section: Neurogenesis In Fishmentioning

confidence: 99%

On the Role of Neurogenesis and Neural Plasticity in the Evolution of Animal Personalities and Stress Coping Styles

Øverli

Sørensen

2016

Brain Behav Evol

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Individual variation in how animals react to stress and environmental change has become a central topic in a wide range of biological disciplines, from evolutionary ecology to biomedicine. Such variation manifests phenotypically as correlated trait-clusters (referred to as coping styles, behavioral syndromes, shyness-boldness, or personality traits). Thresholds for switching from active coping (fight-flight) to inhibition and passive behavior when exposed to stress depend on experience and genetic factors. Comparative research has revealed a range of neuroendocrine-behavioral associations which are conserved throughout the vertebrate subphylum, including factors affecting perception, learning, and memory of stimuli and events. Here we review conserved aspects of the contribution of neurogenesis and other aspects of neural plasticity to stress coping. In teleost fish, brain cell proliferation and neurogenesis have received recent attention. This work reveals that brain cell proliferation and neurogenesis are associated with heritable variation in stress coping style, and they are also differentially affected by short- and long-term stress in a biphasic manner. Routine-dependent and inflexible behavior in proactive individuals is associated with limited neural plasticity. These evolutionarily conserved relationships hold the potential to illuminate the biological background for stress-related neurobiological disorders.

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“…Exposure to a chronic stressor, on the other hand, can be a detriment to both physical and behavioral health, as these conditions increase the risk for a wide range of adverse health outcomes, including accelerated progression of coronary artery disease [1,2]; affective disorders [3,4], eating disorders and metabolic dysregulation [5][6][7][8], addiction [9]; and reproductive compromise [10]. In addition, chronic activation of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis also adversely affects immune function [11], increasing vulnerability to opportunistic disease [12,13]. These adverse health outcomes are secondary to the dysregulation of the LHPA axis that occurs during exposure to chronic stressors [14,15].…”

Section: Introductionmentioning

confidence: 99%

Administration of human leptin differentially affects parameters of cortisol secretion in socially housed female rhesus monkeys

Collura

Hoffman

Wilson

2009

Endocr

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Chronic exposure to psychosocial stress may lead to a dysregulation of the limbic-hypothalamic-pituitary-adrenal axis that results in a number of adverse health outcomes. The fat-derived hormone leptin has been indicated as a potential key component to maintaining homeostasis by enhancing glucocorticoid negative feedback. Using an established model of nonhuman primate social stress, notably social subordination, this study examined the effects of continuous leptin administration on cortisol secretion in female rhesus monkeys. The 20 subjects were maintained in stable five-member social groups with established dominance hierarchies. All females were ovariectomized but received estradiol throughout the study to maintain serum concentrations at early follicular phase levels. Three parameters of cortisol secretion were examined in dominant and subordinate females during control and leptin-treatment conditions: diurnal cortisol secretion; response to a dexamethasone suppression test; and response to a brief separation from their social group. We hypothesized that leptin supplementation would attenuate the hypercortisolemia characteristic of subordinate females. During baseline conditions, subordinate female rhesus monkeys had significantly lower levels of serum leptin compared with more dominant monkeys and were less sensitive to glucocorticoid negative feedback. Exogenous administration of leptin improved glucocorticoid negative feedback in subordinate females and decreased morning cortisol in all animals. However, there were no status differences in response to a social separation test and diurnal rhythm in cortisol during baseline conditions. However, leptin administration did not attenuate the increase in cortisol in response to a social separation. The data presented in this study demonstrate that leptin can attenuate several parameters of cortisol secretion in female rhesus monkeys and thus may play a role in the response of the adrenal glands to socio-environmental stimuli.

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Personality, Coping Style, and Constitutional Neuroimmunology

Cited by 57 publications

References 45 publications

Potential of Environmental Enrichment to Prevent Transgenerational Effects of Paternal Trauma

Potential of Environmental Enrichment to Prevent Transgenerational Effects of Paternal Trauma

On the Role of Neurogenesis and Neural Plasticity in the Evolution of Animal Personalities and Stress Coping Styles

Administration of human leptin differentially affects parameters of cortisol secretion in socially housed female rhesus monkeys

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