Personality and language characteristics in parents from multiple-incidence autism families

Piven, Joseph; Palmer, Pat; Landa, Rebecca; Santangelo, Susan L.; Jacobi, Dinah; Childress, Deb

doi:10.1002/(sici)1096-8628(19970725)74:4<398::aid-ajmg11>3.0.co;2-d

Cited by 224 publications

(138 citation statements)

References 35 publications

(42 reference statements)

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“…[57][58][59][60] In the ICD-10 classification for schizophrenia and related disorders, 7 some of the diagnostic criteria appear to be very close to the criteria for AS. This seems to be valid especially for schizoid personality disorder.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide scan for loci of Asperger syndrome

et al. 2004

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Asperger syndrome (AS), characterised by inadequate social interaction, lack of empathy and a dependence of routines and rituals, is classified as belonging to the autism spectrum disorders (DSM-IV and ICD-10). Although the prevalence of AS has been estimated to range from 0.3 up to 48.4 per 10 000, the phenotype still remains relatively unrecognised by clinicians. Several reports, including the original description by Hans Asperger (1944), have suggested that AS has a strong genetic component. Here, we have performed a genome-wide scan on Finnish families ascertained for AS with a strictly defined phenotype. In the initial scan, Z max 41.5 was observed on nine chromosomal regions, 1q21-22, 3p14-24, 3q25-27, 4p14, 4q32, 6p25, 6q16, 13q31-33 and 18p11. In the fine mapping stage, the highest two-point LOD scores were observed on chromosomes 1q21-22 (D1S484, Z max dom ¼3.58), 3p14-24 (D3S2432, Z max dom ¼2.50) and 13q31-33 (D13S793, Z max dom ¼1.59). The loci on 1q21-22 and 3p14-24 overlap with previously published autism susceptibility loci, and the loci on 1q21-22 and 13q31-33 overlap with the reported schizophrenia susceptibility loci. The present study is the first genome-wide screen in AS and therefore replication data sets are needed to evaluate further the significance of the AS-loci identified here.

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Section: Discussionmentioning

confidence: 99%

Genome-wide scan for loci of Asperger syndrome

et al. 2004

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“…Within these families, there are also elevated rates of social difficulties; higher incidences of cognitive, communication, learning and executive function deficits; increased stereotyped behaviors; and anxiety, affective, language, and pragmatic disorders. 33,[49][50][51][52][53][54][55] Monozygotic twin pair studies have also shown a high concordance rate (60%) for DSM-IV Autistic Disorder, 71% for the broader autistic spectrum phenotype, and 92% for an even broader phenotype of social and communication deficits with stereotyped behaviors that nonetheless were clearly differentiated from normal. In contrast, no concordance for autism was noted in dizygotic twin pairs and only 10% were concordant for some form of cognitive, social or language deficit.…”

Section: Neurology 2000;55:468-479mentioning

confidence: 99%

Practice parameter: Screening and diagnosis of autism

Filipek¹,

Accardo²,

Ashwal³

et al. 2000

Neurology

834

414

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Article abstract-Autism is a common disorder of childhood, affecting 1 in 500 children. Yet, it often remains unrecognized and undiagnosed until or after late preschool age because appropriate tools for routine developmental screening and screening specifically for autism have not been available. Early identification of children with autism and intensive, early intervention during the toddler and preschool years improves outcome for most young children with autism. This practice parameter reviews the available empirical evidence and gives specific recommendations for the identification of children with autism. This approach requires a dual process: 1) routine developmental surveillance and screening specifically for autism to be performed on all children to first identify those at risk for any type of atypical development, and to identify those specifically at risk for autism; and 2) to diagnose and evaluate autism, to differentiate autism from other developmental disorders.This statement has been endorsed

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“…Parents of autistic children perform in the superior range on the Embedded Figures Test [20], visual search tasks [163], and other tasks that require processing of parts and details [102], but are below normal performance at inferring mental state from facial expression [20], a task that demands configural and integrative processing. In addition, parents share difficulties in pragmatic language tasks [87], impairments in some tasks that tap executive function [114], and autistic personality characteristics such as rigidity, aloofness, and anxiety [179,178]. Many first-degree relatives show a disparity between performance IQ and verbal IQ, with the performance score being lower [89,177,87] due to impairment on Picture Arrangement and Picture Completion, both of which demand attention to global, contextual information.…”

Section: Phenotypes Within and Beyond The Diagnosismentioning

confidence: 99%