Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities

Sprugnoli, Giulia; Rossi, Símone; Rotenberg, Alexander; Pascual‐Leone, Álvaro; El-Fakhri, Georges; Golby, Alexandra J.; Santarnecchi, Emiliano

doi:10.1016/j.ebiom.2021.103514

Cited by 12 publications

(8 citation statements)

References 100 publications

(180 reference statements)

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“…27,28 All previous structural and functional connectome analyses have pointed out that network features in brain tumors would provide more useful information for detecting the accumulation of glioma cells and deciding the treatment therapy. 29 Therefore, more studies on the brain network of gliomas should be conducted to broaden and deepen the understanding of brain tumors.…”

Section: Discussionmentioning

confidence: 99%

Fiber Density and Structural Brain Connectome in Glioblastoma Are Correlated With Glioma Cell Infiltration

et al. 2023

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BACKGROUND: Glioblastoma (GBM) preferred to infiltrate into white matter (WM) beyond the recognizable tumor margin. OBJECTIVE: To investigate whether fiber density (FD) and structural brain connectome can provide meaningful information about WM destruction and glioma cell infiltration. METHODS: GBM cases were collected based on inclusion criteria, and baseline information and preoperative MRI results were obtained. GBM lesions were automatically segmented into necrosis, contrast-enhanced tumor, and edema areas. We obtained the FD map to compute the FD and lnFD values in each subarea and reconstructed the structural brain connectome to obtain the topological metrics in each subarea. We also divided the edema area into a nonenhanced tumor (NET) area and a normal WM area based on the contralesional lnFD value in the edema area, and computed the NET ratio. RESULTS: Twenty-five GBM cases were included in this retrospective study. The FD/lnFD value and topological metrics (aCp, aLp, aEg, aEloc, and ar) were significantly correlated with GBM subareas, which represented the extent of WM destruction and glioma cell infiltration. The FD/lnFD values and topological parameters were correlated with the NET ratio. In particular, the lnFD value in the edema area was correlated with the NET ratio (coefficient, 0.92). Therefore, a larger lnFD value indicates more severe glioma infiltration in the edema area and suggests an extended resection for better clinical outcomes. CONCLUSION: The FD and structural brain connectome in this study provide a new insight into glioma infiltration and a different consideration of their clinical application in neurooncology.

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Section: Discussionmentioning

confidence: 99%

Fiber Density and Structural Brain Connectome in Glioblastoma Are Correlated With Glioma Cell Infiltration

et al. 2023

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“…Glioma is the most common malignant primary brain tumor, accounting for 15% of all brain tumors (Ostrom et al, 2021;Siegel et al, 2022). However, despite decades of intensive efforts, glioma remains one of the most challenging cancers to treat, with limited improvement in patient survival (Sprugnoli et al, 2021). Glioblastoma (GBM), the most frequent and aggressive high-grade glioma (HGG, WHO IV), is associated with a mean survival of approximately 16 to 18 months from diagnosis(Lara-Velazquez et al, 2017; Nayak and Reardon, 2017).…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis reveals CP is a potential biomarker and therapeutic target in glioma

Liu

Wang

Wang³

et al. 2023

Preprint

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Purpose: Glioma is a challenging brain tumor with limited treatment options and poor prognosis. Ceruloplasmin (CP), a multicopper protein involved in oxidative stress and iron homeostasis, has been implicated in various cancers but its role in glioma remains unclear. Methods: In this study, we investigated the association between CP expression and various factors, including prognosis, tumor microenvironment (TME), immune infiltration, and immune checkpoint markers. We utilized single-cell sequencing data to assess the expression of CP in both glioma tissues and normal tissues. Furthermore, we conducted in vitro experimentation to evaluate the effects of CP knockdown on glioma cells. Results: Our findings demonstrated a significant correlation between high CP expression and unfavorable clinical characteristics, as well as poor overall survival in glioma patients. Enrichment analysis revealed associations between CP and immune-related pathways, suggesting its involvement in immune regulation. We observed increased immune infiltration in glioma cases exhibiting high CP expression. Additionally, CP expression showed positive correlation with immune checkpoint genes, indicating its potential as an immunotherapy target. Single-cell analysis confirmed the expression of CP in both tumor and immune cells, further supporting its role as a biomarker. Moreover, our in vitro knockdown experiments demonstrated that inhibiting CP suppressed glioma cell proliferation. Conclusion: In summary, our findings suggest that CP is associated with glioma progression, immune regulation, and holds potential therapeutic implications.

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“…Currently, the basis of GBM treatment is still surgical removal of the tumor followed by adjuvant chemotherapy and radiation therapy (the STUPP protocol) [ 60 ]. While several personalized molecular and immune treatment strategies have been tried in high-grade gliomas, their benefit thus far appears limited [ 61 , 62 , 63 , 64 ].…”

Section: Review Of the Literaturementioning

confidence: 99%

ß-Adrenoreceptors in Human Cancers

Kraboth

Kálmán

2023

IJMS

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Cancer is the leading cause of death and represents a significant economic burden worldwide. The numbers are constantly growing as a result of increasing life expectancy, toxic environmental factors, and adoption of Western lifestyle. Among lifestyle factors, stress and the related signaling pathways have recently been implicated in the development of tumors. Here we present some epidemiological and preclinical data concerning stress-related activation of the ß-adrenoreceptors (ß-ARs), which contributes to the formation, sequential transformation, and migration of different tumor cell types. We focused our survey on research results for breast and lung cancer, melanoma, and gliomas published in the past five years. Based on the converging evidence, we present a conceptual framework of how cancer cells hijack a physiological mechanism involving ß-ARs toward a positive modulation of their own survival. In addition, we also highlight the potential contribution of ß-AR activation to tumorigenesis and metastasis formation. Finally, we outline the antitumor effects of targeting the ß-adrenergic signaling pathways, methods for which primarily include repurposed ß-blocker drugs. However, we also call attention to the emerging (though as yet largely explorative) method of chemogenetics, which has a great potential in suppressing tumor growth either by selectively modulating neuronal cell groups involved in stress responses affecting cancer cells or by directly manipulating specific (e.g., the ß-AR) receptors on a tumor and its microenvironment.

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Personalised, image-guided, noninvasive brain stimulation in gliomas: Rationale, challenges and opportunities

Cited by 12 publications

References 100 publications

Fiber Density and Structural Brain Connectome in Glioblastoma Are Correlated With Glioma Cell Infiltration

Fiber Density and Structural Brain Connectome in Glioblastoma Are Correlated With Glioma Cell Infiltration

Integrated analysis reveals CP is a potential biomarker and therapeutic target in glioma

ß-Adrenoreceptors in Human Cancers

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