Personal Fine Particulate Matter Constituents, Increased Systemic Inflammation, and the Role of DNA Hypomethylation

Lei, Xiaoning; Chen, Renjie; Wang, Cuicui; Shi, Jingjin; Zhao, Zhuohui; Li, Weihua; Yan, Beizhan; Chillrud, S. N.; Cai, Jing; Kan, Haidong

doi:10.1021/acs.est.9b02305

Cited by 47 publications

(54 citation statements)

References 40 publications

(74 reference statements)

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“…A time-series study in Hong Kong, China showed that short-term exposure to CO was associated with a reduced risk of hospitalization for COPD (7). However, in Spain, a retrospective study found that elevated CO levels were associated with increased hospital admissions in patients with COPD (8), which was the same as our results. Therefore, further studies are needed to confirm the direct health effects of CO exposure on patients with COPD.…”

Section: Discussionsupporting

confidence: 87%

Exposure Response Relationship of Acute Effects of Air Pollution on Respiratory Diseases — China, 2013−2018

Niu

et al. 2021

China CDC Weekly

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Section: Discussionsupporting

confidence: 87%

Exposure Response Relationship of Acute Effects of Air Pollution on Respiratory Diseases — China, 2013−2018

Niu

et al. 2021

China CDC Weekly

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“…Due to the implementation of air pollution prevention and control strategies in Beijing, the emissions from fossil fuel combustion (e.g., coal combustion) are considerably decreased, while vehicle emissions account for greater proportion over time [ 18 , 45 ]. Accordingly, the components change with the restructuring of pollution sources [ 46 , 47 ], and thus the exposure–health association might not decrease along with the declining concentrations of air pollutants [ 28 , 48 , 49 ]. In addition, the changes of demographic distribution and population susceptibility might also be reasons for the findings [ 28 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Short-Term Exposure to Ambient Air Pollution and Increased Emergency Room Visits for Skin Diseases in Beijing, China

Wang

Zhang

Zhao

et al. 2021

Toxics

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Skin diseases have become a global concern. This study aims to evaluate the associations between ambient air pollution and emergency room visits for skin diseases under the background of improving air quality in China. Based on 45,094 cases from a general hospital and fixed-site monitoring environmental data from 2014–2019 in Beijing, China, this study used generalized additive models with quasi-Poisson regression to estimate the exposure–health associations at lag 0–1 to lag 0–7. PM2.5 and NO2 exposure were associated with increased emergency room visits for total skin diseases (ICD10: L00-L99). Positive associations of PM2.5, PM10, O3 and NO2 with dermatitis/eczema (ICD-10: L20–30), as well as SO2 and NO2 with urticaria (ICD-10: L50) visits were also found. For instance, a 10 μg/m3 increase in PM2.5 was associated with increases of 0.7% (95%CI: 0.2%, 1.2%) in total skin diseases visits at lag 0–5 and 1.1% (95%CI: 0.6%, 1.7%) in dermatitis/eczema visits at lag 0–1, respectively. For PM2.5, PM10 and CO, stronger annual associations were typically observed in the high-pollution (2014) and low-pollution (2018/2019) years. For instance, a 10 μg/m3 increase in PM2.5 at lag 0–5 was associated with increases of 1.8% (95%CI: 1.0%, 2.6%) and 2.3% (95%CI: 0.4%, 4.3%) in total skin disease visits in 2014 and 2018, respectively. Our study emphasizes the necessity of controlling the potential health hazard of air pollutants on skin, although significant achievements in air quality control have been made in China.

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“…Lei et al. reported a significant short-term relationship between lead of PM 2.5 and TNF-α (percent change = 65.20%, 95% CI: 37.07%, 99.10%) ( Lei et al., 2019 ). A meta-analysis of European cohorts reported a significant long-term association between fibrinogen and zinc of PM 2.5 (percent change = 1.2%, 95%CI: 0.1%, 2.4%), but an insignificant association for PM 2.5 mass ( Hampel et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis

Tang

Cheng

et al. 2020

Environmental Pollution

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Inflammation and the coagulation cascade are considered to be the potential mechanisms of ambient particulate matter (PM) exposure-induced adverse cardiovascular events. Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and fibrinogen are arguably the four most commonly assayed markers to reflect the relationships of PM with inflammation and blood coagulation. This review summarized and quantitatively analyzed the existing studies reporting short- and long-term associations of PM 2.5 (PM with an aerodynamic diameter ≤2.5 μm)/PM 10 (PM with an aerodynamic diameter≤10 μm) with important inflammation and blood coagulation markers (TNF-α, IL-6, IL-8, fibrinogen). We reviewed relevant studies published up to July 2020, using three English databases (PubMed, Web of Science, Embase) and two Chinese databases (Wang-Fang, China National Knowledge Infrastructure). The OHAT tool, with some modification, was applied to evaluate risk of bias. Meta-analyses were conducted with random-effects models for calculating the pooled estimate of markers. To assess the potential effect modifiers and the source of heterogeneity, we conducted subgroup analyses and meta-regression analyses where appropriate. The assessment and correction of publication bias were based on Begg’s and Egger’s test and “trim-and-fill” analysis. We identified 44 eligible studies. For short-term PM exposure, the percent change of a 10 μg/m 3 PM 2.5 increase on TNF-α and fibrinogen was 3.51% (95% confidence interval (CI): 1.21%, 5.81%) and 0.54% (95% confidence interval (CI): 0.21%, 0.86%) respectively. We also found a significant short-term association between PM 10 and fibrinogen (percent change = 0.17%, 95% CI: 0.04%, 0.29%). Overall analysis showed that long-term associations of fibrinogen with PM 2.5 and PM 10 were not significant. Subgroup analysis showed that long-term associations of fibrinogen with PM 2.5 and PM 10 were significant only found in studies conducted in Asia. Our findings support significant short-term associations of PM with TNF-α and fibrinogen. Future epidemiological studies should address the role long-term PM exposure plays in inflammation and blood coagulation markers level change.

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Personal Fine Particulate Matter Constituents, Increased Systemic Inflammation, and the Role of DNA Hypomethylation

Cited by 47 publications

References 40 publications

Exposure Response Relationship of Acute Effects of Air Pollution on Respiratory Diseases — China, 2013−2018

Exposure Response Relationship of Acute Effects of Air Pollution on Respiratory Diseases — China, 2013−2018

Short-Term Exposure to Ambient Air Pollution and Increased Emergency Room Visits for Skin Diseases in Beijing, China

The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis

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