Personal exposure to PM2.5 oxidative potential and its association to birth outcomes

Impact of COVID-19 lockdown on particulate matter oxidative potential at urban backgroundversustraffic sites

“…The OP analysis was performed on PM extracted from collected filter samples on both sites using a simulated lung fluid (SLF) solution at 25 µg ml -1 iso-mass concentration (28), similar to the techniques applied in other studies by our group (11,47,50).…”

“…The OP analysis was performed on PM extracted from collected lter samples on both sites using a simulated lung uid (SLF) solution at 25 mg ml −1 iso-mass concentration, 28 similar to the techniques applied in other studies by our group. 11,47,50 Two assays were used to assess OP activity, namely (1) dithiothreitol (DTT) and (2) ascorbic acid (AA) assays. The OP activity or OP v is based on the OP consumption (nmol min −1 ) of the particles normalized by the sampled air volume (m 3 ), representing the OP exposure in each sample.…”

Ambient air pollution and adverse birth outcomes: A review of underlying mechanisms

“…However, other studies examining links between air pollution concentrations, markers of oxidative stress and an adverse birth outcome do not provide evidence that an increased oxidative burden with increased exposure during pregnancy is associated with preterm or negative indices of fetal growth. [52][53][54] Studies that have sought to evaluate the involvement of oxidative stress by examining whether the OP of PM 2.5 modifies the relation between PM 2.5 mass concentrations/exposures and adverse birth outcomes have reported mixed results, possibly indicative of different assays employed and birth outcomes evaluated 64,65 (Table S1). Studies focusing on gene-environment interactions in pregnant women suggest an interaction between exposure to air pollution during pregnancy and genetic polymorphisms in antioxidant genes that results in an increased risk of preterm delivery 66,67 (Table S1).…”

Source apportionment of oxidative potential depends on the choice of the assay: insights into 5 protocols comparison and implications for mitigation measures

“…8,12,15,16,18,23,24,29 These ndings agree with previous cohort studies showing that respiratory health was more strongly associated with OPDTT than with PM mass. 24 Other effects, such as restrictions in foetal growth 20,30 and reduced lung function in children, 26 have been found in cohort studies where consistent associations with OPDTT have been observed. OP is a relatively simple measure of PM redox activity but also reects a complex and dynamic interplay of particle size, composition, and chemistry.…”