Personal exposure to NO2 and benzene in the Cape Town region of South Africa is associated with shorter leukocyte telomere length in women

Everson, Frans; Martens, Dries S.; Nawrot, Tim S.; Goswami, Nandu; Mthethwa, Mashudu; Webster, Ingrid; Mashele, Nyiko; Charania, Sana; Kamau, Festus; Boever, Patrick De; Strijdom, Hans

doi:10.1016/j.envres.2019.108993

Cited by 17 publications

(6 citation statements)

References 53 publications

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“…Another important environmental factor that can activate cellular senescence is air pollution. It is reported that some pollutants in Brazil, China, and South Africa may predispose cellular senescence by inducing telomere shortening or reducing catalase activity [260][261][262]. Furthermore, endothelial cells, skin keratinocytes, and mouse lung fibroblast can enter cellular senescence mode because of pollutants, fine dust, particulate matter 2.5, and polycyclic aromatic hydrocarbons via inducing senescence regulators, ROS, or the ATM serine/threonine kinase/H2A histone family member X pathway [263][264][265].…”

Section: Lifestyle Modificationsmentioning

confidence: 99%

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

et al. 2022

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Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role of MSCs in tissue homeostasis, aging-related diseases, and cellular therapy is clinically suggested. As aging is a universal problem that has large socioeconomic effects, an improved understanding of the concepts of aging can direct public policies that reduce its adverse impacts on the healthcare system and humanity. Several studies of aging have been carried out over several years to understand the phenomenon and different factors affecting human aging. A reduced ability of adult stem cell populations to reproduce and regenerate is one of the main contributors to the human aging process. In this context, MSCs senescence is a major challenge in front of cellular therapy advancement. Many factors, ranging from genetic and metabolic pathways to extrinsic factors through various cellular signaling pathways, are involved in regulating the mechanism of MSC senescence. To better understand and reverse cellular senescence, this review highlights the underlying mechanisms and signs of MSC cellular senescence, and discusses the strategies to combat aging and cellular senescence. Graphical Abstract

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Section: Lifestyle Modificationsmentioning

confidence: 99%

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

et al. 2022

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“…When a study consisting of coke-oven workers (n = 1,005, males) looked at the association of PAH exposure and mosaic loss of chromosome Y (mLOY), one of the most common structure somatic event contributing to disease and mortality, found that a 10-fold increase in urinary 1-hydroxynaphthalene (1-OHNa), 1-hydroxyphenanthrene (1-OHPh), 2-OHPh, 1-hydroxypyrene (1-OHP) resulted in increased incidence of mLOY in a dosedependent linear association (Liu et al, 2020). In another study that monitored healthy women residing in the Cape Town region of South Africa revealed that levels of personal NO 2 and benzene exposure was inversely associated with leukocyte telomere length, where the magnitude of effects corresponded to > 6 year increase in chronological age (Everson et al, 2020). For a more recent update on air pollution and skin aging the readers are highly suggested to consult a recent review (Schikowski and Hüls, 2020).…”

Section: Nilson 2002mentioning

confidence: 99%

The Chemical Exposome of Human Aging

Misra

2020

Front. Genet.

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Aging is an inevitable biological phenomenon displayed by single cells and organs to entire organismal systems. Aging as a biological process is characterized as a progressive decline in intrinsic biological function. Understanding the causative mechanisms of aging has always captured the imagination of researchers since time immemorial. Although both biological and chronological aging are well defined and studied in terms of genetic, epigenetic, and lifestyle predispositions, the hallmarks of aging in terms of small molecules (i.e., endogenous metabolites to chemical exposures) are limited to obscure. On top of the endogenous metabolites leading to the onset and progression of healthy aging, human beings are constantly exposed to a natural and anthropogenic “chemical” environment round the clock, from conception till death, affecting one’s physiology, health and well-being, and disease predisposition. The research community has started gaining sizeable insights into deciphering the aging factors such as immunosenescence, nutrition, frailty, inflamm-aging, and diseases till date, without much input from their interaction with exogenous chemical exposures. The “exposome” around us, mostly, accelerates the process of aging by affecting the internal biological pathways and signaling mechanisms that result in the deterioration of human health. However, the entirety of exposome on human aging is far from established. This review intends to catalog the known and established associations of the exposome from past studies focusing on aging in humans and other model organisms. Further discussed are the current technologies and informatics tools that enable the study of aging exposotypes, and thus, provide a window of opportunities and challenges to study the “aging exposome” in granular details.

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“…At the same time, research also found that activation of Keap1 can lead to decreased self‐renewal ability of hematopoietic stem cells 23 and thus participate in leukemia progression 24 . Besides, hematopoietic stem cell (HSC) senescence contributed to the development of hematopoietic diseases, 25 and multiple environmental pollutants are particularly sensitive inducements of cells senescence 26 . Senescence cells expressed senescence‐associated β‐galactosidase (SA‐β‐gal), associated with abnormal expression of senescence executive proteins p53/p21 27 .…”

Section: Introductionmentioning

confidence: 99%

“…24 Besides, hematopoietic stem cell (HSC) senescence contributed to the development of hematopoietic diseases, 25 and multiple environmental pollutants are particularly sensitive inducements of cells senescence. 26 Senescence cells expressed senescence-associated β-galactosidase (SA-β-gal), associated with abnormal expression of senescence executive proteins p53/p21. 27 As reported that exposure to brominated flame retardants (BFRs) could lead to the dysregulation of p53/p21 pathway and induced cell senescence.…”

mentioning

confidence: 99%

Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL/6J mice

Guo

Cheng

Wang

et al. 2023

Environmental Toxicology

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Nanoplastics (NPs) has become a worrying serious environmental problem. However, the toxicological effects and mechanisms of NPs on hematopoiesis are still unknown. To this end, male C57BL/6J mice were directly exposed to the serial concentration gradient of polystyrene NPs (PSNPs, 0, 30, 60, and 120 μg d), respectively, for 42 days by intragastric administration. Results show that PSNPs were clearly visible in bone tissues, meanwhile, induced the count of major blood indicators (WBC, RBC, and LYM) decreased. H&E staining displayed that exposed to PSNPs can cause hematopoietic damage of BM and extramedullary hematopoiesis in spleen. Flow cytometry result show that the proportion of LSK represented a dose‐dependent significantly decreased after PSNPs exposure. Further research found that PSNPs can cause the systemic oxidative stress occurs manifested as MDA accumulated. In addition, as the dose of PSNPs increased, the fluorescence intensity of Keap1 and p53 in femur sections gradually increased, meanwhile, the expression of cell oxeiptosis signal pathway Keap1/PGAM5/AIFM1 and the cell senescence signal pathway p53/p21 was all increased, markedly. Overall, our study demonstrated that PSNPs exposure caused oxidative stress, potentially resulting in cell oxeiptosis and senescence to develop haematotoxicity in C57BL/6J mice.

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Personal exposure to NO2 and benzene in the Cape Town region of South Africa is associated with shorter leukocyte telomere length in women

Cited by 17 publications

References 53 publications

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

The Chemical Exposome of Human Aging

Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL/6J mice

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