Persistierende Schwellung nach Spülung eines Abszesses mit Octenisept®

Bauer, Bernd; Majic, M.; Rauthe, Stephan; Bröcker, Eva‐B.; Kerstan, Andrea

doi:10.1007/s00113-011-2116-5

Cited by 10 publications

(12 citation statements)

References 7 publications

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“…Octenisept ® shows considerable tissue toxicity in vivo, including -but not restricted toblood vessel damage. Deterioration of endothelial cells followed by oedema and continued tissue damage can be seen histologically [21]. Some studies have also focused on the cytotoxicity of antiseptics on human chondrocytes.…”

Section: The Comparative Irritant Properties Of Antisepticsmentioning

confidence: 98%

A comparison of the irritant and allergenic properties of antiseptics

Lachapelle¹

2014

European Journal of Dermatology

144

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Section: The Comparative Irritant Properties Of Antisepticsmentioning

confidence: 98%

A comparison of the irritant and allergenic properties of antiseptics

Lachapelle¹

2014

European Journal of Dermatology

144

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“…In the use of antiseptic solutions, the characteristics of the individual substances, the type of wound (wound cavities, protein error) as well as the individual risk profile (allergies) of the patient should be taken into consideration [49,51,52].…”

Section: Antisepsis and Breakthrough Of Chronic Inflammationmentioning

confidence: 99%

Evidence‐based topical management of chronic wounds according to the T.I.M.E. principle

Klein

Schreml

Dolderer

et al. 2013

J Deutsche Derma Gesell

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SummaryThe number of patients suffering from chronic wound healing disorders in Germany alone is estimated to be 2.5-4 million. Therapy related expenses reach 5-8 billion Euros annually. This number is partially caused by costly dressing changes due to non-standardized approaches and the application of non-evidence-based topical wound therapies. The purpose of this paper is to elucidate a straightforward principle for the management of chronic wounds, and to review the available evidence for the particular therapy options. The T.I.M.E.-principle (Tissue management, Inflammation and infection control, Moisture balance, Epithelial [edge] advancement) was chosen as a systematic strategy for wound bed preparation. Literature was retrieved from the PubMed and Cochrane Library databases and subjected to selective analysis.Topical wound management should be carried out according to a standardized principle and should further be synchronized to the phases of wound healing. Despite the broad implementation of these products in clinical practice, often no benefit exists in the rate of healing, when evaluated in meta-analyses or systematic reviews. This insufficient evidence is additionally limited by varying study designs. In case of non-superiority, the results suggest to prefer relatively inexpensive wound dressings over expensive alternatives. Arbitrary endpoints to prove the effectiveness of wound dressings, contribute to the random use of such therapies. Defining rational endpoints for future studies as well as the deployment of structured therapy strategies will be essential for the economical and evidence-based management of chronic wounds.

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“…Auch für Polyvidonjod konnte in einer kontrollierten Studie keine histologisch nachweisbare Gewebetoxizität gezeigt werden [50]. Umgekehrt verhält es sich mit Octenidinlösungen, welche mit 1,73-2,11 relativ hohe BI-Werte aufweisen, über deren unerwünschte Arzneimittelwirkungen mit Ödembildung und Gewebsnekrosen bei Anwendung unter Druck oder Verbleib in Wundhöhlen bereits wiederholt in "Rote-Hand-Briefen" informiert wurde [49,51]. Polyhexanidlösungen gelten bezüglich ihrer Gewebetoxizität und ihrer Kontaktsensibilisierung als risikoarm [44,52,53].…”

Section: Pathophysiologie Chronischer Wundenunclassified