Persistently poor pregnancy outcomes in women with insulin dependent diabetes

Simmons, David

doi:10.1136/bmj.315.7103.263

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Introduction3

Congenital Malformations and Timing Of Anatomical Scan1

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2001

2011

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Cited by 9 publications

(4 citation statements)

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“…Pregnancy in a diabetic mother is still associated with additional risk, both to mother and offspring [1]. Recent audits from two centres in England identified persistently poorer outcomes when compared with the overall obstetric experience [2,3].…”

Section: Introductionmentioning

confidence: 99%

Obstetric and diabetic care for pregnancy in diabetic women: 10 years outcome analysis, 1985–1995

et al. 2001

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Section: Introductionmentioning

confidence: 99%

Obstetric and diabetic care for pregnancy in diabetic women: 10 years outcome analysis, 1985–1995

et al. 2001

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“…Of the group that could benefit from preconception care, approximately 50–60% can successfully achieve targeted levels of glycemic control. Therefore, substantial numbers of diabetic women will be exposed to hyperglycemia during organogenesis41–44.…”

Section: Congenital Malformations and Timing Of Anatomical Scanmentioning

confidence: 99%

Ultrasound biometry evolves in the management of diabetes in pregnancy

Langer

2005

Ultrasound in Obstet & Gyne

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“…Although normalization of the risk of congenital malformations has been reported, many clinics report that in practice this is hard to achieve [15]. This is particularly due to a large proportion of pregnancies (generally around 50%) among women with known, preexisting, type 1 or type 2 diabetes remaining unplanned or without prior optimal glycemic control [15].…”

Section: Introductionmentioning

confidence: 98%

The utility and efficacy of the new insulins in the management of diabetes and pregnancy

Simmons

2002

Curr Diab Rep

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The quest for tight glucose control has led to the development of insulin analogues (insulin lispro, insulin aspart, insulin glargine) designed to optimize glucose control while minimizing the impact of insulin therapy on daily life. Women with diabetes are increasingly likely to become pregnant on these new products and to benefit from their use while pregnant. Caution over the use of new medications in pregnancy has limited experience, but increasing evidence is emerging that use of insulin lispro is not associated with excess risk of fetal malformations, is associated with similar or better outcomes during pregnancy, and is preferred over regular insulin. Similar evidence for the other insulin analogues has yet to emerge, but is unlikely to be dissimilar.

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Persistently poor pregnancy outcomes in women with insulin dependent diabetes

Cited by 9 publications

References 11 publications

Obstetric and diabetic care for pregnancy in diabetic women: 10 years outcome analysis, 1985–1995

Obstetric and diabetic care for pregnancy in diabetic women: 10 years outcome analysis, 1985–1995

Ultrasound biometry evolves in the management of diabetes in pregnancy

The utility and efficacy of the new insulins in the management of diabetes and pregnancy

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