Persistent tubular resistance to aldosterone in infants with congenital hydronephrosis corrected neonatally

Marra, Giuseppina; Goj, V.; Appiani, Aldo Claris; agnola, C A Dell'; Tirelli, Silvia; Tadini, B.; Nicolini, Umberto; Cavanna, G; Assael, B.M.

doi:10.1016/s0022-3476(87)80398-0

Cited by 36 publications

(25 citation statements)

References 6 publications

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“…In contrast to classical pseudohypoaldosteronism in which familial cases are common, only sporadic cases have been reported in transient pseudohypoaldosteron ism [6,[10][11][12], In our cases the aldosterone receptors in both parents were normal, further supporting the hypoth esis that the disorder in these patients is acquired.…”

Section: Discussionsupporting

confidence: 68%

“…Resistance towards aldosterone associated with ob structive uropathy has been described previously, how ever, the mechanism is not known [6,[10][11][12][13], We were able to demonstrate, for the first time, reduced aldoste rone receptors which might explain the apparent resis tance to aldosterone. In contrast to the patients with clas sical, familial pseudohypoaldosteronism, the amount of aldosterone receptors in obstructive uropathy return to normal after successful surgical correction of the obstruc tion.…”

Section: Discussionsupporting

confidence: 52%

“…bacteria toxins, damage the aldosterone recep tors, leading to aldosterone resistance. This would explain the transient nature of the defect, although the continuing elevation of aldosterone as well as the plasma renin activi ty in our patient and in various reports in the literature seem to indicate permanent damage to at least some of the aldosterone receptors [10,11].…”

Section: Discussionsupporting

confidence: 49%

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Transient Pseudohypoaldosteronism in Obstructive Renal Disease with Transient Reduction of Lymphocytic Aldosterone Receptors

et al. 1993

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We report two patients with transient pseudohypoaldosteronism due to obstructive renal disease. Both patients presented with a salt-losing episode simulating adrenal insufficiency. In one patient, transient reduction of aldosterone receptors could be documented, while in the second patient the clinical and biochemical parameters were consistent with transient pseudohypoaldosteronism. Aldosterone receptors were normal in both patients when studied after the surgical correction of the obstruction.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionsupporting

confidence: 52%

Section: Discussionsupporting

confidence: 49%

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Transient Pseudohypoaldosteronism in Obstructive Renal Disease with Transient Reduction of Lymphocytic Aldosterone Receptors

et al. 1993

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“…Secondary PHA in infants with various structural urinary tract lesions has been described [1,13,17]. Surgical correction of these lesions does not always result in hormonal restoration to normal [17]. This is the first case to our knowledge of a persistent secondary PHA in the presence of a dysplastic kidney.…”

Section: Discussionmentioning

confidence: 93%

“…In a previous study of children with urinary tract infection and renal scarring, the hormonal imbalance also persisted after successful treatment of the infection [16]. Secondary PHA in infants with various structural urinary tract lesions has been described [1,13,17]. Surgical correction of these lesions does not always result in hormonal restoration to normal [17].…”

Section: Discussionmentioning

confidence: 99%

Rare causes of acute hyperkalemia in the 1st week of life

et al. 2004

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We describe three neonates with hyperkalemia and renal salt wasting during the 1st week of life. Endocrinological evaluation led to the diagnosis of selective hypoaldosteronism (HA) in two neonates and secondary pseudohypoaldosteronism (PHA) in one. The infant with PHA developed a urinary tract infection, and radiological investigation demonstrated a small dysplastic left kidney with vesicoureteral reflux. The electrolyte and hormonal disturbances in this infant persisted throughout the first months of life. The two infants with selective HA improved rapidly after administration of fludrocortisone orally and the electrolytes and renin values returned to normal. Secondary PHA and selective HA should be considered in the differential diagnosis in salt-losing neonates during the first days of life. Renal ultrasonography, urine culture, and assays of aldosterone and plasma renin activity should be performed in any infant presenting with hyperkalemia and salt wasting after the exclusion of congenital adrenal hyperplasia.

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Management of Impaired Renal Function in the Newborn

Morgan

Jones

2018

Rickham's Neonatal Surgery

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Persistent tubular resistance to aldosterone in infants with congenital hydronephrosis corrected neonatally

Cited by 36 publications

References 6 publications

Transient Pseudohypoaldosteronism in Obstructive Renal Disease with Transient Reduction of Lymphocytic Aldosterone Receptors

Transient Pseudohypoaldosteronism in Obstructive Renal Disease with Transient Reduction of Lymphocytic Aldosterone Receptors

Rare causes of acute hyperkalemia in the 1st week of life

Management of Impaired Renal Function in the Newborn

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