Persistent Truncus Arteriosus: A Classification According to Anatomic Types

Collett, Robert W.; Edwards, Jesse E.

doi:10.1016/s0039-6109(16)32803-1

Cited by 571 publications

(257 citation statements)

References 43 publications

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“…In NCA embryos of the three-injection series, a commonly observed cardiovascular defect was TA, in which one great artery arises from the base of the heart and gives origin to the coronary, pulmonary, and systemic arteries (Abbott, 1927;Lev and Saphir, 1942;Collett, 1949;Van Praagh and Van Praagh, 1965; Fig. 5D-F).…”

Section: Ablation Of Neural Crest In the Mouse Embryo Results In A Wimentioning

confidence: 99%

Temporal–spatial ablation of neural crest in the mouse results in cardiovascular defects

Porras

Brown

2007

Developmental Dynamics

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Neural crest cells are thought to play a critical role in human conotruncal morphogenesis and dysmorphogenesis. Much of our understanding of the contribution of neural crest to cardiovascular patterning comes from ablation and transplantation experiments in avian species. Although fate mapping experiments in mice suggests a conservation of function, the functional requirement for neural crest in cardiovascular development in mammals has not been formally tested. We used a novel two component genetic system for the temporal-spatial ablation of neural crest in the mouse. Affected embryos displayed a spectrum of cardiovascular outflow tract defects and aortic arch patterning abnormalities. We show that the severity of the cardiovascular phenotype is directly related to the level and extent of neural crest ablation. This is the first report of cardiac neural crest ablation in mammals, and it provides important insight into the role of the mammalian neural crest during cardiovascular development. Developmental Dynamics 237:153-162, 2008.

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Section: Ablation Of Neural Crest In the Mouse Embryo Results In A Wimentioning

confidence: 99%

Temporal–spatial ablation of neural crest in the mouse results in cardiovascular defects

Porras

Brown

2007

Developmental Dynamics

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“…The PAs originate from the arterial trunk in various patterns25, 26 and the presence of normal‐sized PAs results in bilateral PH, unless there is stenosis of the origin of 1 or both PAs (present in half of the patients). When branch pulmonary artery stenosis is severe, it may “protect” the respective lung from developing pulmonary vascular disease; segmental PH develops in the contralateral lung 26, 27.…”

Section: Conditions In Which Segmental Ph May Developmentioning

confidence: 99%

Definition and Management of Segmental Pulmonary Hypertension

Dimopoulos

Diller

Opotowsky

et al. 2018

JAHA

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“…If we move to the A-P septum, the truncus types 2, 3, and 4 represent a complete failure of A-P septation, whereas in truncus type 1, there is only a partial A-P septation deficiency being the pulmonary trunk present. In this specific context, concerning the anatomic variations in the pattern of origin of the pulmonary and aortic tributaries from the ascending arterial trunk, it is important to refer to the study of Collett and Edwards (1949), who provided, to the best of our knowledge, the first clear-cut classification of truncus malformation.…”

Section: Truncal Septation: Development Of the Arterial Valvesmentioning

confidence: 99%

Cardiac outflow tract: A review of some embryogenetic aspects of the conotruncal region of the heart

et al. 2006

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A review concerning some embryogenetic aspects of the cardiac outflow tract is presented. Two main topics are discussed: the truncal septation and the secondary heart field. In the context of the septation of the truncus arteriosus, the development of the arterial valves is largely discussed, particularly in reference to the sinuses of Valsalva. Emphasis is also given to the fate of the external myocardial wall of the truncus arteriosus, as this primordial myocardial surface disappears later in the development. Molecular genetics data concerning Sox4 and NF-Atc transcription factors are correlated in the present review with rare forms of truncus malformations encountered in human pathology. The roles exerted by the secondary heart field and the neural crest on the development and growth of the conotruncal musculature are largely discussed. Reported experimental ablations of both secondary heart field and neural crest, showed conotruncal defects such as persistent truncus arteriosus, tetralogy of Fallot, and double-outlet right ventricle, which were considered as the result of a short outflow tract causing, ultimately, a lack of conotruncal rotation. In this regard, some morphologic correlations are carried out, in the present review, between these experimental animal models and human malformations, and it is thought that this sort of conotruncal defects cannot be explained always in terms of conotruncal hypoplasia. Finally, influence of Pitx2c, a left-right laterality signaling gene, on the modulation of the conotruncal rotation, as most recently reported, is emphasized in terms of very likely multifactorial contributions in the embryogenesis of the conotruncal region of the heart. Anat Rec Part A, 288A: 936-943, 2006

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Persistent Truncus Arteriosus: A Classification According to Anatomic Types

Cited by 571 publications

References 43 publications

Temporal–spatial ablation of neural crest in the mouse results in cardiovascular defects

Temporal–spatial ablation of neural crest in the mouse results in cardiovascular defects

Definition and Management of Segmental Pulmonary Hypertension

Cardiac outflow tract: A review of some embryogenetic aspects of the conotruncal region of the heart

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