Persistent tailoring of MSC activation through genetic priming
Michael A. Beauregard,
Guy C. Bedford,
Daniel A. Brenner
et al.
Abstract:Mesenchymal stem/stromal cells (MSCs) are an attractive platform for cell therapy due to their safety profile and unique ability to secrete broad arrays of immunomodulatory and regenerative molecules. Yet, MSCs are well known to require preconditioning or priming to boost their therapeutic efficacy. Current priming methods offer limited control over MSC activation, yield transient effects, and often induce expression of pro-inflammatory effectors that can potentiate immunogenicity. Here, we describe a "genetic… Show more
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