Persistent Symptoms in Post-COVID-19 Patients Attending Follow-Up OPD at Sukraraj Tropical and Infectious Disease Hospital (STIDH), Kathmandu, Nepal

Bastola, Anup; Nepal, Richa; Shrestha, B; Maharjan, Kijan; Shrestha, Sanjay; Chalise, Bimal Sharma; Neupane, Jenish

doi:10.3390/tropicalmed6030113

Cited by 16 publications

(24 citation statements)

References 19 publications

(21 reference statements)

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“…However, in that study, only 28.1% of patients had cough at hospital admission (26) which was much lower than that in our study (79%) and other studies in China (8,(32)(33)(34)(35). Compared with studies from European and American countries, the prevalence of post-COVID-19 cough in Asian countries seemed to be lower (20-41.9% vs. 27.5-29%) (20)(21)(22)(23)(24)(25)(26)(27)36). It is unclear whether the ethnic difference contributed to the prevalence of cough.…”

Section: Discussioncontrasting

confidence: 86%

“…Our study showed that symptoms of COVID-19 significantly reduced long after discharge, however, approximately one-fifth of patients still presented with at least one symptom, including cough, dyspnea, fatigue and anorexia at the follow-up. The incidence of symptoms in our study is significantly lower compared with previous studies (17,18,(21)(22)(23)26,27). We attributed it to a longer period after discharge, which also implied that COVID-19 infection would rarely cause severe and longterm sequelae.…”

Section: Discussioncontrasting

confidence: 73%

“…Another survey conducted on H1N1 influenza found that postinfectious cough occurred in 8.5% of patients and 2.8% of patients developed chronic cough (16). In online surveys, cough was reported in 20-64% of patients 2-6 months after the onset of symptoms of COVID-19 (17)(18)(19)(20)(21)(22)(23) and 2.5-23.3% after 6 months (24)(25)(26)(27). The results of the prevalence of cough in the long-term follow-up are quite different.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and risk factors for postinfectious cough in discharged patients with coronavirus disease 2019 (COVID-19)

Chen¹,

Zhang²,

Zeng³

et al. 2022

J Thorac Dis

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Background: Cough is one of the most common symptoms of coronavirus disease 2019 .However, the prevalence of persistent cough in recovered patients with COVID-19 during a longer followup remained unknown. This study aims to investigate the prevalence, and risk factors for postinfectious cough in COVID-19 patients after discharge. Methods:We conducted a follow-up study for 129 discharged patients with laboratory-confirmed COVID-19 in two large hospitals located in Hubei Province, China from January 2020 to December 2020.Baseline demographics, comorbidities and smoking history were extracted from the medical record. Current symptoms and severity were recorded by a uniform questionnaire. Spirometry, diffuse function and chest computed tomography (CT) were performed on part of patients who were able to return to the outpatient department at follow-up. Results:The median (interquartile range) follow-up time was 8.1 (7.9-8.5) months after discharge.The mean (standard deviation) age was 51.5 (14.9) years and 57 (44.2%) were male. A total of 27 (20.9%) patients had postinfectious cough (>3 weeks), 6 patients (4.7%) had persistent cough by the end of follow-up, including 3 patients with previous chronic respiratory diseases or current smoking. Other symptoms included dyspnea (6, 4.7%), sputum (4, 3.1%), fatigue (4, 3.1%), and anorexia (4, 3.1%) by the end of follow-up.Thirty-six of 41 (87.8%) patients showed impaired lung function or diffuse function, and 39 of 50 (78.0%) patients showed abnormal CT imaging. Patients with postinfectious cough demonstrated more severe and more frequent cough during hospitalization (P<0.001), and more chronic respiratory diseases (P=0.01).In multivariate logistic regression analysis, digestive symptoms during hospitalization [odds ratio (OR) 2.95, 95% confidence interval (CI): 1.10-7.92] and current smoking (OR 6.95, 95% CI: 1.46-33.14) were significantly associated with postinfectious cough of COVID-19.Conclusions: A small part of patients developed postinfectious cough after recovery from COVID-19, few patients developed chronic cough in spite of a higher proportion of impaired lung function and abnormal lung CT image. Current smoking and digestive symptoms during hospitalization were risk factors for postinfectious cough in COVID-19.

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Section: Discussioncontrasting

confidence: 86%

Section: Discussioncontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and risk factors for postinfectious cough in discharged patients with coronavirus disease 2019 (COVID-19)

Chen¹,

Zhang²,

Zeng³

et al. 2022

J Thorac Dis

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“…At the beginning of the COVID-19 pandemic, little was known about long-lasting symptoms following acute COVID-19. The current state of research now indicates various physical, cognitive, and psychological symptoms in affected patients which persist over weeks or months and depend on disease severity (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). According to current publications, more than 1/3 of patients with acute COVID-19 develop long COVID-19 symptoms (23,(29)(30)(31).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to neurocognitive symptoms in patients with long-COVID, the results of a meta-analysis found that 45% of hospitalized patients showed symptoms of depression and 47% showed symptoms of anxiety (42). The frequency of depression and anxiety symptoms among COVID-19 patients decreased within several weeks after disease onset but was still present in 9% (26) to 13.6% (17) of patients for anxiety and in ∼20% of patients for depression (26). Younger age, working in the healthcare sector, and female gender seem to be risk factors for depression and anxiety (43).…”

Section: Introductionmentioning

confidence: 99%

Rehabilitation and Return-to-Work of Patients Acquiring COVID-19 in the Workplace: A Study Protocol for an Observational Cohort Study

Müller

Zwingmann

Auerswald

et al. 2022

Front. Rehabilit. Sci.

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BackgroundIn 2020, the novel coronavirus disease (COVID-19) developed into a worldwide pandemic. The course of COVID-19 is diverse, non-specific, and variable: Affected persons suffer from physical, cognitive, and psychological acute and long-term consequences. The symptoms influence everyday life activities, as well as work ability in the short or long-term. Healthcare professionals are considered particularly vulnerable to COVID-19 compared to the general population. In Germany, COVID-19 is recognized as an occupational disease or a work-related accident under certain conditions. Disease-specific rehabilitation is recommended for patients following acute COVID-19 to recover physical and neuropsychological performance and to improve work ability. Currently, there are limited findings on the short-term or long-term impact of COVID-19 as a recognized occupational disease or work-related accident, as well as on rehabilitation programs and associated influencing factors. Thus, the present research project will investigate these questions.MethodsFor this observational cohort study, post-acute patients with COVID-19 as a recognized occupational disease or work-related accident according to the insurance regulations for COVID-19 will be recruited at the BG Hospital for Occupational Disease in Bad Reichenhall, Germany. All participants will complete a comprehensive multimodal and interdisciplinary inpatient rehabilitation program for a duration of at least 3 weeks, beginning after their acute COVID-19 infection and depending on their individual indication and severity of disease. Participants will complete medical, functional, motor, psychological, and cognitive measurements at four time points (at the beginning (T1) and end (T2) of inpatient rehabilitation; 6 (T3) and 12 (T4) months after the beginning of inpatient rehabilitation).DiscussionThe present research project will help to assess and describe long-term effects of COVID-19 as a recognized occupational disease or work-related accident on physical and neuropsychological health, as well as on everyday activities and work ability of affected insured persons. In addition, this study will investigate influencing factors on severity and course of COVID-19. Furthermore, we will examine rehabilitation needs, measures, occurring specifics, and the feasibility of the rehabilitation procedure and disease development in the patients. The results of the intended study will further advance common recommendations for targeted and tailored rehabilitation management and participation in inpatient rehabilitation.Clinical Trial Registrationwww.drks.de, identifier: DRKS00022928.

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Undiagnosed Long COVID-19 in China Among Non-vaccinated Individuals: Identifying Persistent Symptoms and Impacts on Patients' Health-Related Quality of Life

Zhang

Lei

Zhang

et al. 2022

J Epidemiol Glob Health

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Is Long COVID-19 under-diagnosed? The definition of this new condition has received many contributions, and it is still under development as a great variety of symptoms have been associated to it. This study explores the possibility that there are non-diagnosed cases among individuals who have been infected by SARS-CoV-2 and have not been vaccinated. The long-term symptoms identified among a sample 255 individuals have been associated to Long COVID-19 by recent literature. The study relates these symptoms to risk factors and health-related quality of life (HRQoL) negative impacts. The individuals were screened 1 year after discharge to explore its potential relation to Long COVID-19. Patients diagnosed with COVID-19 and discharged from designated hospitals in a Chinese province between January and April 2020 were included in this study. They received computed tomography (CT) scans one month after discharge. One year after discharge, patients were invited to physical examination and interviewed with questionnaire on health-related quality of life (HRQoL) and post-COVID-19 symptoms. Tobit regression and Logistic regression were applied to evaluate the risk factors for health utility value and pain/discomfort and anxiety/depression. One year after discharge, 39.61% patients complained of several of the symptoms associated to Long COVID-19. More than half had abnormal chest CT. Previous studies focused on the post-COVID-19 symptoms and chest CT findings of patients, but few studies have assessed the COVID-19-associated risk factors for health-related quality of life.

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Persistent Symptoms in Post-COVID-19 Patients Attending Follow-Up OPD at Sukraraj Tropical and Infectious Disease Hospital (STIDH), Kathmandu, Nepal

Cited by 16 publications

References 19 publications

Prevalence and risk factors for postinfectious cough in discharged patients with coronavirus disease 2019 (COVID-19)

Prevalence and risk factors for postinfectious cough in discharged patients with coronavirus disease 2019 (COVID-19)

Rehabilitation and Return-to-Work of Patients Acquiring COVID-19 in the Workplace: A Study Protocol for an Observational Cohort Study

Undiagnosed Long COVID-19 in China Among Non-vaccinated Individuals: Identifying Persistent Symptoms and Impacts on Patients' Health-Related Quality of Life

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