Persistent sensitization of depressive‐like behavior and thermogenic response during maternal separation in pre‐ and post‐weaning guinea pigs

Schneider, Randi L.; Schiml, Patricia A.; Deak, Terrence; Hennessy, Michael B.

doi:10.1002/dev.20609

Cited by 12 publications

(30 citation statements)

References 161 publications

(172 reference statements)

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“…2). These increases are not associated with increases in locomotor activity, and neither the behavioral nor the core temperature change can be accounted for by the increasing age of the animals (Schneider et al, 2012; Yusko et al, 2012). The sensitization of the fever response implies a sensitization of inflammatory mechanisms, though this remains to be directly tested.…”

Section: Modeling Effects Of Maternal Separation On the Development Omentioning

confidence: 93%

“…Even a single 3-hr separation increases the level of passive, but not active, behaviors observed during separation the following day (Schneider et al, 2012). If 3-week-old pups are then separated a third time 4 or 10 days after the first separation, the same heightened level of passive behavior is observed (Hennessy, Paik, Caraway, Schiml, & Deak, 2011; Schneider et al, 2012; Yusko, Hawk, Schiml, Deak, & Hennessy, 2012; Fig. 2).…”

Section: Modeling Effects Of Maternal Separation On the Development Omentioning

confidence: 99%

“…Mean core temperature of pups undergoing repeated separation. * p < 0.05 versus each of the other separations (bottom) (adapted from Schneider et al, 2012). …”

Section: Figurementioning

confidence: 99%

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Filial attachment and its disruption: Insights from the guinea pig

Hennessy

2014

Developmental Psychobiology

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Guinea pigs are precocial rodents that show evidence of a selective attachment to the mother who, in turn, exhibits little active maternal care. Effects of separation in guinea pigs are, therefore, more likely to reflect the disruption of attachment than the removal of, or alterations in, patterns of maternal care. Here, effects in guinea pigs of the presence or absence of the mother on psychobiological endpoints and of maternal separation on depressive-like behavior are reviewed. It is argued that results with guinea pigs often align more closely with those of nonhuman primates than those of laboratory rats and mice, and that the guinea pig offers a valuable translational model for studies of the consequences of attachment and its disruption.

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Section: Modeling Effects Of Maternal Separation On the Development Omentioning

confidence: 93%

Section: Modeling Effects Of Maternal Separation On the Development Omentioning

confidence: 99%

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Filial attachment and its disruption: Insights from the guinea pig

Hennessy

2014

Developmental Psychobiology

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“…Attachment disruptions can lead to severe psychological and social impairments in both mother and offspring. For instance, mother guinea pigs demonstrate a passive, depressive-type response when separated from their pups across a wide range of infant ages (Schneider, Schiml, Deak, & Hennessy, 2012). As discussed above in the section on social buffering, social support from conspecifics also appears to be important across many species for dealing with difficult circumstances.…”

Section: Social Complexitymentioning

confidence: 99%

The Psychology of Cows

Marino¹,

Allen²

2017

ABC

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-Domestic cows (Bos taurus) are consumed worldwide as beef and veal, kept as dairy product producers, employed as draft animals in labor, and are used for a long list of other products, including leather and manure. But despite global reliance on cows for thousands of years, most people's perception of them is as plodding herd animals with little individual personality and very simple social relationships or preferences. Yet, a review of the scientific literature on cow behavior points to more complex cognitive, emotional and social characteristics. Moreover, when cow behavior is addressed, it is almost entirely done within the framework of and applied to their use as food commodities. Therefore, there is relatively little attention to the study of cow intelligence, personality and sociality at a basic comparative level. In this review, we examine the current state of scientific knowledge about cows within an objective comparative framework, describing their cognitive, emotional, and social characteristics. Our aim is to provide a more veridical and objective current summary of cow psychology on its own terms and in ways which will facilitate better-informed comparisons with other animals. Moreover, an understanding of the capabilities and characteristics of domestic cows will, it is hoped, advance our understanding of who they are as individuals.

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“…Subsequent work revealed that the sensitization would persist for more than just 24 hr. For instance, Schneider et al [41] found that pups separated on two consecutive days, and then again 10 days after the first, exhibited more of the passive depressive-like behavior during both of the later separations, as well as a larger and more-rapid fever response, particularly during the last separation.…”

Section: Introductionmentioning

confidence: 99%

Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation

Hennessy

Stafford

Yusko-Osborne

et al. 2015

Physiology & Behavior

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Early life stress can increase susceptibility for later development of depressive illness though a process thought to involve inflammatory mediators. Isolated guinea pig pups exhibit a passive, depressive-like behavioral response and fever that appear mediated by proinflammatory activity, and which sensitize with repeated separations. Treatment with an anti-inflammatory can attenuate the behavioral response during the initial separation and separation the following day. Here we used the cyclooxygenase inhibitor naproxen to examine the role of prostaglandins in mediating the depressive-like behavior and core body temperature of young guinea pigs during an initial separation, separation the next day, and separation 10 days after the first. The passive, depressive-like behavior as well as fever sensitized with repeated separation. Three days of injection with 14 mg/kg of naproxen prior to the initial separation reduced depressive-like behavior during all three separations. A 28 mg/kg dose of naproxen, however, had minimal effect on behavior. Fever during the early separations was moderated by naproxen, but only at the higher dose. These results suggest a role of prostaglandins in the behavioral and febrile response to maternal separation, and particularly in the sensitization of depressive-like behavior following repeated separation.

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Persistent sensitization of depressive‐like behavior and thermogenic response during maternal separation in pre‐ and post‐weaning guinea pigs

Cited by 12 publications

References 161 publications

Filial attachment and its disruption: Insights from the guinea pig

Filial attachment and its disruption: Insights from the guinea pig

The Psychology of Cows

Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation

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