Persistent reduction of conduction velocity and myelinated axon damage in vibrated rat tail nerves

Loffredo, Michael; Yan, Ji‐Geng; Kao, Dennis S.; Zhang, Lin Ling; Matloub, Hani S.; Riley, Denise

doi:10.1002/mus.21235

Cited by 30 publications

(23 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously, our laboratory an association of prolonged vibration with decreased NCV [8] as well as a reduction of retrograde axoplasmic transport [4,14]. The structural damage demonstrated by this study may be underlying neuropathological mechanism that leads to the decreases in NCV and retrograde transport.…”

Section: Discussionsupporting

confidence: 62%

A Quantitative Study of Vibration Injury to Peripheral Nerves—Introducing a New Longitudinal Section Analysis

Davis

Wang

Zhang

et al. 2014

Hand (New York, N,Y.)

Self Cite

View full text Add to dashboard Cite

Purpose Long-term vibrations are known to cause neurovascular diseases, which are common in workers who operate handheld power tools or motor vehicles. Understanding the neuropathology of vibration-induced nerve injury is critical to its prevention and treatment. This study aims to evaluate whether light microscopy of longitudinal nerve sections can be used as a simple yet effective method for quantifying nerve injury. Methods The rats were split into two groups that were subjected to vibration (4 h/day) for 7 or 14 days. They were then allowed to rest for varying periods of time. Longitudinal sections of the tail nerves were examined under light microscopy. Injuries to the nerves were classified into three types, counted, tallied, and then divided by the length of the nerve being studied.

show abstract

Section: Discussionsupporting

confidence: 62%

A Quantitative Study of Vibration Injury to Peripheral Nerves—Introducing a New Longitudinal Section Analysis

Davis

Wang

Zhang

et al. 2014

Hand (New York, N,Y.)

Self Cite

View full text Add to dashboard Cite

show abstract

“…Rodent models are useful to investigate the mechanisms of injury and pain [23,39,78,85,86]. Vibration of isolated limbs or the tail induces local myelin damage, endothelial cell death, growth factor upregulation, and increased vulnerability to reinjury [3,21,26,49,53].…”

Section: Discussionmentioning

confidence: 99%

“…Workers using vibrating hand tools exhibit nerve damage, pain, and paraesthesia in the hands [34,66]. Isolated vibration of the limb or tail in the rat produces damage in myelinated fibers [49,53]. WBV of the rat induces deformation in the cervical spine, which if repeated daily produces long-lasting behavioral sensitivity [11].…”

Section: Introductionmentioning

confidence: 99%

Whole-body Vibration at Thoracic Resonance Induces Sustained Pain and Widespread Cervical Neuroinflammation in the Rat

Zeeman

Kartha

Jaumard

et al. 2015

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Background Whole-body vibration (WBV) is associated with back and neck pain in military personnel and civilians. However, the role of vibration frequency and the physiological mechanisms involved in pain symptoms are unknown. Questions/purposes This study asked the following questions: (1) What is the resonance frequency of the rat spine for WBV along the spinal axis, and how does frequency of WBV alter the extent of spinal compression/ extension? (2) Does a single WBV exposure at resonance induce pain that is sustained? (3) Does WBV at resonance alter the protein kinase C epsilon (PKCe) response in the dorsal root ganglia (DRG)? (4) Does WBV at resonance alter expression of calcitonin gene-related peptide (CGRP) in the spinal dorsal horn? (5) Does WBV at resonance alter the spinal neuroimmune responses that regulate pain? Methods Resonance of the rat (410 ± 34 g, n = 9) was measured by imposing WBV at frequencies from 3 to 15 Hz. Separate groups (317 ± 20 g, n = 10/treatment) underwent WBV at resonance (8 Hz) or at a nonresonant frequency (15 Hz). Behavioral sensitivity was assessed throughout to measure pain, and PKCe in the DRG was quantified as well as spinal CGRP, glial activation, and cytokine levels at Day 14. Results Accelerometer-based thoracic transmissibility peaks at 8 Hz (1.86 ± 0.19) and 9 Hz (1.95 ± 0.19, mean difference [MD] 0.290 ± 0.266, p \ 0.03), whereas the video-based thoracic transmissibility peaks at 8 Hz (1.90 ± 0.27), 9 Hz (2.07 ± 0.20), and 10 Hz (1.80 ± 0.25, MD 0.359 ± 0.284, p \ 0.01). WBV at 8 Hz produces more cervical extension (0.745 ± 0.582 mm, MD 0.242 ± 0.214, p \ 0.03) and compression (0.870 ± 0.676 mm, MD 0.326 ± 0.261, p \ 0.02) than 15 Hz (extension, 0.503 ± 0.279 mm; compression, 0.544 ± 0.400 mm). Pain is longer lasting (through Day 14) and more robust (p \ 0.01) after WBV at the resonant frequency (8 Hz) compared with 15 Hz WBV. PKCe in the nociceptors of the DRG increases according to the severity of WBV with greatest increases after 8 Hz WBV (p \ 0.03). However, spinal CGRP, cytokines, and glial activation are only evident after painful WBV at resonance. Conclusions WBV at resonance produces long-lasting pain and widespread activation of a host of nociceptive and neuroimmune responses as compared with WBV at a nonresonance condition. Based on this work, future investigations into the temporal and regional neuroimmune response to resonant WBV in both genders would be useful.

show abstract

“…In addition, cold hypersensitivity is both a frequent symptom of vibration exposure [9,12,13,29] as well as a common feature of some forms of peripheral neuropathy [18,27,73]. Finally, vibration is well established to produce peripheral neuropathies in both animals [14,30,33,36,52,55] and humans [9,19,29,32,37,46,77,78]. Thus, failure to have well-described neuropathic muscle pain syndromes may be due, in part, to patients being asked to use descriptors commonly employed for neuropathic pain in the cutaneous domain.…”

Section: Discussionmentioning

confidence: 99%

Neuropathic pain-like alterations in muscle nociceptor function associated with vibration-induced muscle pain

Chen

Green

Levine

2010

Pain

View full text Add to dashboard Cite

We recently developed a rodent model of the painful muscle disorders induced by occupational exposure to vibration. In the present study we used this model to evaluate the function of sensory neurons innervating the vibration-exposed gastrocnemius muscle. Activity of 74 vibration-exposed and 40 control nociceptors, with mechanical receptive fields in the gastrocnemius muscle, were recorded. In vibration-exposed rats ~15% of nociceptors demonstrated an intense and long-lasting barrage of action potentials in response to sustained suprathreshold mechanical stimulation (average of 2635 action potentials with frequency of ~44 Hz during a 1 minute suprathreshold stimulus) much greater than has been reported to be produced even by potent inflammatory mediators. While these high-firing nociceptors had lower mechanical thresholds than the remaining nociceptors, exposure to vibration had no effect on conduction velocity and did not induce spontaneous activity. Hyperactivity was not observed in any of 19 neurons from vibration exposed rats pretreated with intrathecal antisense for the IL-6 receptor subunit gp130. Since vibration can injure peripheral nerves, and IL-6 has been implicated in painful peripheral neuropathies, we suggest that the dramatic change in sensory neuron function and development of muscles pain, induced by exposure to vibration, reflects a neuropathic muscle pain syndrome.

show abstract

Persistent reduction of conduction velocity and myelinated axon damage in vibrated rat tail nerves

Cited by 30 publications

References 23 publications

A Quantitative Study of Vibration Injury to Peripheral Nerves—Introducing a New Longitudinal Section Analysis

A Quantitative Study of Vibration Injury to Peripheral Nerves—Introducing a New Longitudinal Section Analysis

Whole-body Vibration at Thoracic Resonance Induces Sustained Pain and Widespread Cervical Neuroinflammation in the Rat

Neuropathic pain-like alterations in muscle nociceptor function associated with vibration-induced muscle pain

Contact Info

Product

Resources

About