Persistent post-surgical pain and experimental pain sensitivity in the Tromsø study: Comorbid pain matters

Johansen, Aslak; Schirmer, Henrik; Stubhaug, Audun; Nielsen, Christopher Sivert

doi:10.1016/j.pain.2013.10.013

Cited by 62 publications

(47 citation statements)

References 43 publications

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“…48 Secondary hyperalgesia due to enhanced central processing may not necessarily directly affect postoperative spontaneous pain ratings, but may play a role in the development of chronic postsurgical pain. 9,17,20,21,28 Other studies using an incision model have shown that pretraumatic lidocaine injection, applied before an incision on the forearm of healthy volunteers, suppressed spontaneous pain, flare, and primary hyperalgesia more effectively than posttraumatic injection. Inhibition of secondary hyperalgesia by pretraumatic block indicated induction by peripheral input.…”

Section: Introductionmentioning

confidence: 99%

A novel human surrogate model of noninjurious sharp mechanical pain

Shabes

Schloss

Magerl

et al. 2016

Pain

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We propose a blade as a noninjurious nociceptive stimulus modeling sharp mechanical pain and yielding acute pain and hyperalgesia responses with closer proximity to incision-induced pain/hyperalgesia than punctate or blunt pressure mechanical pain models. Twenty-six healthy men and women were investigated to compare a small incision in the left forearm with noninvasive stimuli of different shapes and modalities to the right forearm. The magnitude and time course of incisional and blade-induced pain were assessed by numerical rating scales. Affective vs sensory components of pain experience were differentiated using a pain sensation questionnaire. The magnitude and time course of the axon reflex vasodilator response and of secondary hyperalgesia following a 7-second blade application were assessed. The maximum blade or incisional pain was similar (visual analogue scale [mean ± SD]: 32.9 ± 22.5 [blade] vs. 33.6 ± 29.8 [incision]), and both time courses matched closely in the first 10 seconds (paired t test; P = 0.5-1.0), whereas incision but not blade was followed by a second phase of pain, probably related to the tissue injury (decrease to half maximum pain 8 ± 2 vs. 33 ± 35 seconds; P < 0.01). Affective pain scores were significantly lower than sensory scores for all stimuli (P < 0.001). Comparing blade and incision, patterns of affective and sensory pain descriptors exhibited a remarkably similar pattern. Hence, we suggest the blade as novel model of sharp mechanical pain, which will be useful in investigating postoperative/mechanical pain and the role of self-injurious behavior in, eg, patients with borderline personality disorder.

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Section: Introductionmentioning

confidence: 99%

A novel human surrogate model of noninjurious sharp mechanical pain

Shabes

Schloss

Magerl

et al. 2016

Pain

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“…This probably reflects random differences between the two study populations. In a large epidemiologic study, cold pressor data were shown to be influenced by age, gender, chronic pain and hypertension 20,21. In addition, small differences in context and methods are known to influence pain scoring.…”

Section: Discussionmentioning

confidence: 99%

Validation of the Norwegian Pain Sensitivity Questionnaire

Valeberg¹,

Pedersen²,

Girotto³

et al. 2017

JPR

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Background and purposeThere is a large variation in people’s reactions to painful stimuli. Although some conditions are more painful, the variation between people is larger than the reaction to pain across conditions. Induced experimental pain is one way to assess some aspects of these differences in pain perception. Experimental nociceptive testing is time consuming and not always feasible in a clinical setting. In order to overcome the obstacles of assessing pain sensitivity using experimental stimulation, the Pain Sensitivity Questionnaire (PSQ) was developed. The purpose of this study is to validate the Norwegian version of the PSQ.MethodsConstruct validity was examined through an exploratory principal component factor analysis with varimax rotation. Internal consistency was measured by Cronbach’s alpha reliability for subscales and the total PSQ. As confounding variables such as age and gender may contribute to the experience of pain, a regression analysis was performed with demographic variables and PSQ scores as independent variables and the experimental measures of pain as the dependent variable.ResultsThe factor analysis yielded at two factor solution, with an eigenvalue greater than one, explain 58% of the variance. Cronbach’s alpha for the PSQ was 0.92. In the regression analysis, only PSQ scores contributed to explain the experimental pain intensity and tolerance. Gender only influenced the experimental pain threshold, as men had statistically significant higher heat pain threshold than women.ConclusionThis study shows that PSQ is a valid and reliable questionnaire and might be a promising instrument for assessing pain sensitivity in Norwegian clinical settings. Further studies are needed to examine whether the PSQ can be used in clinical settings to predict postoperative pain and the development of chronic pain.

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“…Interestingly, Johansen and coworkers found co-morbid pain to be strongly associated with persistent pain in the surgical site (15).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Persistent Pain and its Influence on Maternal Wellbeing After Cesarean Section

Niklasson¹,

Öhman²,

Segerdahl³

et al. 2016

Obstetric Anesthesia Digest

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PostprintThis is the accepted version of a paper published in Acta Obstetricia et Gynecologica Scandinavica. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Citation for the original published paper (version of record):Niklasson, B., Georgsson Öhman, S., Segerdahl, M., Blanck, A. (2015) Risk factors for persistent pain and its influence on maternal wellbeing after cesarean section. Acta Obstetricia et Gynecologica Conflicts of InterestThe authors have no conflict of interest.Persistent pain and Cesarean section 3 AbstractObjectives. To investigate the overall incidence and risk factors for persistent pain and its interference with daily life after cesarean section (CS).Design. Prospective long-term follow up study. Setting. Karolinska University Hospital, Stockholm, Sweden. Population. 260 healthy women who underwent elective CS. Methods: Key message boxSevere postoperative pain, a first time CS and if the operation was performed for psychological reasons were risk factors for developing persistent pain. Parameters related to quality of life were significantly impaired in women with long-term pain.Persistent pain and Cesarean section 5

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Persistent post-surgical pain and experimental pain sensitivity in the Tromsø study: Comorbid pain matters

Cited by 62 publications

References 43 publications

A novel human surrogate model of noninjurious sharp mechanical pain

A novel human surrogate model of noninjurious sharp mechanical pain

Validation of the Norwegian Pain Sensitivity Questionnaire

Risk Factors for Persistent Pain and its Influence on Maternal Wellbeing After Cesarean Section

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