Abstract:The apparent resolution of these papilloma lesions with cryotherapy suggests that this may be a useful treatment intervention for persistent canine papilloma lesions. Spontaneous resolution may still have taken place; consequently, large scale clinical trials are required to demonstrate unequivocally that this mode of therapy, as with other therapeutic modalities, is really effective in the treatment of canine papillomatosis.
“…The use of cryotherapy for viral lesions has been successfully documented in both human and veterinary medicine. Cryotherapy intervention in three dogs affected by persistent papilloma utilising a 5–6 freeze‐thaw cycle (15–30 s) was reported to be a highly effective treatment modality 7. Given the severity and extensive nature of the CPV growths, surgically debulking and ablating the growths first provided better penetration for cryotherapy administration.…”
Section: Discussionmentioning
confidence: 99%
“…The lesions were frozen with liquid nitrogen using a Mini‐Cryogun (Brymill, Vernon, Connecticut, USA). A more aggressive previously described freeze‐thaw cycle technique was used 7. Clindamycin hydrochloride capsules (Ranbaxy) 7.6 mg/kg orally twice daily for 1 week was restarted to prevent secondary infection and interferon was continued.…”
A 3-year-old, 29.5 kg female, spayed, labrador retriever cross with a 5-month history of severe, persistent papillomas affecting the oral mucous membranes was successfully treated using a multimodal approach that included staged aggressive cryotherapy. On presentation, verrucous growths varying in sizes of 2 mm–3 cm were appreciated affecting all tissues of the oral cavity. There were two alopecic, pedunculated growths with frond-like projections approximately 4 mm by 4 mm and 1 cm by 4 mm on the left pelvic paw. While the growths on the paws resolved with minimal intervention, the oral verrucous growths remained. A combination of interferon alpha-2B, canine papillomavirus-1 autologous vaccine, surgical excision, carbon dioxide laser ablation and aggressive cryotherapy led to complete resolution and continued remission of the canine oral viral papillomas.
“…The use of cryotherapy for viral lesions has been successfully documented in both human and veterinary medicine. Cryotherapy intervention in three dogs affected by persistent papilloma utilising a 5–6 freeze‐thaw cycle (15–30 s) was reported to be a highly effective treatment modality 7. Given the severity and extensive nature of the CPV growths, surgically debulking and ablating the growths first provided better penetration for cryotherapy administration.…”
Section: Discussionmentioning
confidence: 99%
“…The lesions were frozen with liquid nitrogen using a Mini‐Cryogun (Brymill, Vernon, Connecticut, USA). A more aggressive previously described freeze‐thaw cycle technique was used 7. Clindamycin hydrochloride capsules (Ranbaxy) 7.6 mg/kg orally twice daily for 1 week was restarted to prevent secondary infection and interferon was continued.…”
A 3-year-old, 29.5 kg female, spayed, labrador retriever cross with a 5-month history of severe, persistent papillomas affecting the oral mucous membranes was successfully treated using a multimodal approach that included staged aggressive cryotherapy. On presentation, verrucous growths varying in sizes of 2 mm–3 cm were appreciated affecting all tissues of the oral cavity. There were two alopecic, pedunculated growths with frond-like projections approximately 4 mm by 4 mm and 1 cm by 4 mm on the left pelvic paw. While the growths on the paws resolved with minimal intervention, the oral verrucous growths remained. A combination of interferon alpha-2B, canine papillomavirus-1 autologous vaccine, surgical excision, carbon dioxide laser ablation and aggressive cryotherapy led to complete resolution and continued remission of the canine oral viral papillomas.
“…The main advantages of LN‐cryotherapy are the selective destruction of diseased tissue without damaging the surrounding normal area and the avoidance of general anaesthesia . In the past, cryosurgery in dogs has been described in sedated or anaesthetized patients . Benign sebaceous or follicular tumours are common in dogs and they can be numerous .…”
Section: Introductionmentioning
confidence: 99%
“…1 In the past, cryosurgery in dogs has been described in sedated or anaesthetized patients. [2][3][4][5] Benign sebaceous or follicular tumours are common in dogs and they can be numerous. 6 Surgery under general anaesthesia is usually suggested to treat these lesions.…”
Background
Cryotherapy can be used to treat benign skin lesions without general anaesthesia. This technique has only been described in anaesthetized dogs.
Objective
To describe the feasibility, safety and efficacy of cryotherapy to treat benign skin tumours in conscious dogs.
Animals
Twenty‐five client‐owned dogs with 52 skin tumours diagnosed as benign sebaceous neoplasia (46) or follicular cysts (six).
Methods and materials
Cryotherapy was performed in conscious dogs using a liquid nitrogen spray technique with a handheld spray‐release system. If needed, cryotherapy was repeated every three to four weeks until complete cure was achieved or for a maximum of eight treatments. Effectiveness and adverse effects were recorded.
Results
Resolution was obtained for 29 of 52 lesions (57%) with a median number of one to two cryotherapy sessions. Eighteen of 52 (35%) lesions shrank to <0.1 cm. In one case, the tumour enlarged after cryotherapy, and histopathological examination of the excisional biopsy revealed an apocrine gland carcinoma. Pain and discomfort during the treatment were the most common adverse effects (33%).
Conclusions and clinical importance
In the present study, cryotherapy was possible in conscious dogs and proved to be effective to cure or reduce the size of benign sebaceous tumours and follicular cysts. The procedure is safe but the degree of pain during the treatment needs to be further investigated. Worsening of the lesion after cryotherapy suggests the need for surgical removal and histopathological examination.
“…Die Prognose ist bei Adenomen gut und bei Karzinomen je nach Ausmaß und Stadium vorsichtig.TherapieBeim Junghund ist meist keine Therapie nötig, da es in der Regel zur Spontanremission kommt[18]. Bei einer Traumatisierung oder beim älteren Hund ist eine (kryo-)chirurgische Therapie indiziert[26]. Umstritten ist die Herstellung einer Autovakzine.…”
Beim Hund sind Hauttumoren ein häufiger Grund für eine Vorstellung beim Tierarzt. Ihre Malignität wird
deutlich unterschätzt, denn immerhin verhalten sich etwa 20–30 % aller Hauttumoren beim Hund maligne
[19]. Eine gute Diagnostik und eine adäquate Therapie sind daher
essenziell für die weitere Prognose [12].
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