Persistent over-expression of specific CC class chemokines correlates with macrophage and T-cell recruitment in mdx skeletal muscle

Porter, John D.; Guo, Wei; Merriam, Anita P.; Khanna, Sangeeta; Cheng, Georgina; Zhou, Xiaohua; Andrade, Francisco H.; Richmonds, Chelliah R.; Kaminski, Henry J.

doi:10.1016/s0960-8966(02)00242-0

Cited by 89 publications

(87 citation statements)

References 60 publications

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“…Factor XIIIa crosslinks fibrin during blood coagulation though its transglutaminase activity, however, there is accumulating evidence that the protein also has roles in cardiovascular biology [26], possibly through macrophage activation [27,28]. Macrophages are known to infiltrate dystrophic muscle [29], which may explain the lower level of this protein in serum. The same peptide has also previously been identified by mass spectrometry in human serum where a Val34Leu mutation of the protein is correlated with a lower incidence of myocardial infarction and ischemic stroke [30], where cardiovascular abnormalities are well characterized in the mdx mouse [31].…”

Section: Discussionmentioning

confidence: 99%

Serum protein profiling in mice: Identification of Factor XIIIa as a potential biomarker for muscular dystrophy

et al. 2008

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Protein profiling in blood serum by fractionation and MS analysis has been applied in mice to assess its applicability as a fast, economical alternative to current DNA and RNA analyses for diagnosis of neuromuscular disorders. Mass spectra of peptides and proteins were generated using serum from dystrophin-deficient mdx and control mice by WCX ClinProt bead fractionation, followed by MALDI-MS. Double cross-validatory linear discriminant and logistic regression data analysis methods were compared with a new Bayesian logistic regression method. These were evaluated on their ability to discriminate between healthy and dystrophic samples, and to identify the discriminatory peaks in the mass spectra. All three approaches classified the spectra with comparable misclassification rates (between 18.4 and 20.6%), with much overlap between the differential peaks identified between the methods. The differential peak pattern from the Bayesian method was sparser and easier to interpret than from the other two methods, without compromising classifying strength. One of the two main differentiating peaks at m/z 3908 was identified as an N-terminal peptide of coagulation Factor XIIIa, previously identified in human serum. This work underlines the translational aspect of serum protein profiling in mice and supports a further study with serum from patients with neuromuscular disorders.

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Section: Discussionmentioning

confidence: 99%

Serum protein profiling in mice: Identification of Factor XIIIa as a potential biomarker for muscular dystrophy

et al. 2008

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“…Interestingly, many growth factors and chemokines, such as basic fibroblast growth factor (bFGF), 6 monocyte chemoattractant protein-1 (MCP-1), 7,8 and nerve growth factor, 9 are upregulated in mdx mice. However, their role in DMD pathogenesis is still unclear.…”

Section: See P 3290mentioning

confidence: 99%

Enhanced Arteriogenesis and Wound Repair in Dystrophin-Deficient mdx Mice

et al. 2004

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Background-The absence of functional dystrophin in Duchenne muscular dystrophy (DMD) patients and in mdx mice results in progressive muscle degeneration associated with necrosis, fibrosis, and inflammation. Because vascular supply plays a key role in tissue repair, we examined whether new blood vessel development was altered in mdx mice. Methods and Results-In a model of hindlimb ischemia on femoral artery dissection, hindlimb perfusion, measured by laser Doppler imaging, was higher in mdx mice (0.67Ϯ0.26) than in wild-type (WT) mice (0.33Ϯ0.18, PϽ0.03). In keeping with these data, a significant increase in arteriole length density was found in mdx mice (13.6Ϯ8.4 mm/mm 3 ) compared with WT mice (7.8Ϯ4.6 mm/mm 3 , PϽ0.03). Conversely, no difference was observed in capillary density between mice of the 2 genotypes. The enhanced regenerative response was not limited to ischemic skeletal muscle, because in a wound-healing assay, mdx mice showed an accelerated wound closure rate compared with WT mice. Moreover, a vascularization assay in Matrigel plugs containing basic fibroblast growth factor injected subcutaneously revealed an increased length density of arterioles in mdx (46.9Ϯ14.7 mm/mm 3 ) versus WT mice (19.5Ϯ5.8 mm/mm 3 , PϽ0.001). Finally, serum derived from mdx mice sustained formation of endothelium-derived tubular structures in vitro more efficiently than WT serum.Conclusions-These results demonstrate that arteriogenesis is enhanced in mdx mice both after ischemia and skin wounding and in response to growth factors.

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“…Chemokines are important for the migration of muscle precursor cells during embryonic myogenesis (Vasyutina et al, 2005;Yusuf et al, 2006) and for macrophage infiltration into damaged muscle tissue (McLennan, 1996;Robertson et al, 1993). Furthermore, chemokines and their receptors are expressed by diseased or regenerating muscle tissue (Hirata et al, 2003;Porter et al, 2003;Sachidanandan et al, 2002;Warren et al, 2005;Warren et al, 2004;Civatte et al, 2005;Demoule et al, 2009). Finally, chemokines are known to regulate migration of several cell types postnatally, such as immune cells, sperm and metastasizing cancer cells (Kim, 2004;Kim, 2005;Stebler et al, 2004;Bleul et al, 1996;Isobe et al, 2002;Miyazaki et al, 2006;Vandercappellen et al, 2008;Muciaccia et al, 2005a;Muciaccia et al, 2005b).…”

Section: Introductionmentioning

confidence: 99%

Chemokine expression and control of muscle cell migration during myogenesis

Griffin

Apponi

Long

et al. 2010

Journal of Cell Science

133

105

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SummaryAdult regenerative myogenesis is vital for restoring normal tissue structure after muscle injury. Muscle regeneration is dependent on progenitor satellite cells, which proliferate in response to injury, and their progeny differentiate and undergo cell-cell fusion to form regenerating myofibers. Myogenic progenitor cells must be precisely regulated and positioned for proper cell fusion to occur. Chemokines are secreted proteins that share both leukocyte chemoattractant and cytokine-like behavior and affect the physiology of a number of cell types. We investigated the steady-state mRNA levels of 84 chemokines, chemokine receptors and signaling molecules, to obtain a comprehensive view of chemokine expression by muscle cells during myogenesis in vitro. A large number of chemokines and chemokine receptors were expressed by primary mouse muscle cells, especially during times of extensive cell-cell fusion. Furthermore, muscle cells exhibited different migratory behavior throughout myogenesis in vitro. One receptor-ligand pair, CXCR4-SDF-1 (CXCL12), regulated migration of both proliferating and terminally differentiated muscle cells, and was necessary for proper fusion of muscle cells. Given the large number of chemokines and chemokine receptors directly expressed by muscle cells, these proteins might have a greater role in myogenesis than previously appreciated.

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Persistent over-expression of specific CC class chemokines correlates with macrophage and T-cell recruitment in mdx skeletal muscle

Cited by 89 publications

References 60 publications

Serum protein profiling in mice: Identification of Factor XIIIa as a potential biomarker for muscular dystrophy

Serum protein profiling in mice: Identification of Factor XIIIa as a potential biomarker for muscular dystrophy

Enhanced Arteriogenesis and Wound Repair in Dystrophin-Deficient mdx Mice

Chemokine expression and control of muscle cell migration during myogenesis

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