Persistent organic personality change as rare psychiatric manifestation of MELAS syndrome

Köller, Hubertus; Kornischka, Jürgen; Neuen-Jacob, Eva; Saleh, Andreas; Giesen, Hans-Jürgen von; Schmiedel, Janet; Reichmann, Heinz; Hartung, Hans‐Peter

doi:10.1007/s00415-003-0260-8

Cited by 12 publications

(9 citation statements)

References 9 publications

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“…Signs indicating ADHD in childhood have been reported in a middle-aged female patient with a mtDNA rearrangement [68]. Personality alterations, in some cases followed by cognitive decline, have been described in patients with mitochondrial disease with confirmed mtDNA mutations [34,76].…”

Section: Neuropsychiatric Symptoms Of Childhood and Personality Altermentioning

confidence: 96%

Is a "Mitochondrial Psychiatry" in the Future? A Review

Gardner¹,

Boles

2005

CPSR

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The field of "mitochondrial medicine" has advanced rapidly since the first patient with a mitochondrial disorder, a concept primarily used for defects of the respiratory chain, was described in 1962 and the first mitochondrial DNA (mtDNA) mutations were described in 1988. Because of the ubiquitous requirement for energy and unique aspects of mtDNA genetics, mtDNA mutations are known to cause a bewildering spectrum of clinical manifestations. However, because of its high-energy requirement, brain is the primary tissue affected in mitochondrial disorders. Using a variety of approaches, mitochondrial function has been shown in numerous studies to be abnormal in patients with schizophrenia and depression. Although less studied, an increase of psychiatric symptoms and disorders, in particular depression, are likely present in patients with mitochondrial disorders. The major categories of drugs used to treat schizophrenia and depression have been demonstrated to exert effects on mitochondria. The authors conclude that an association between energy metabolism and the mental disorders of schizophrenia and depression has been well documented, but that no conclusive evidence as yet demonstrates a causal relationship. A "mitochondrial psychiatry" model is proposed in which a moderate reduction in mitochondrial energy metabolism, genetically determined and/or acquired, is one predisposing factor in the multi-factorial development of certain chronic mental disorders. Clinical implications of our hypothesis, present and future, include the presence of co-morbid somatic symptoms/conditions, and specific treatment at least in highly-selected cases.

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Section: Neuropsychiatric Symptoms Of Childhood and Personality Altermentioning

confidence: 96%

Is a "Mitochondrial Psychiatry" in the Future? A Review

Gardner¹,

Boles

2005

CPSR

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show abstract

“…2) [2]. Psychiatric abnormalities in MIDs include impaired consciousness [12], impaired alertness, concentration, orientation, reasoning [13,14], acute or chronic confusional state, hallucinations [13], personality change [14][15][16], or unsteadiness [2,17].…”

Section: Clinical Abnormalitiesmentioning

confidence: 99%

Mitochondrial disorders, cognitive impairment and dementia

Finsterer

2009

Journal of the Neurological Sciences

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“…Psychiatric abnormalities are a frequent finding in RCDs and include impaired consciousness [27], impairment of alertness, concentration, orientation, reasoning, mood (depression) [28,29], acute or chronic confusional state [30,31], hallucinations [28], or personality change [32][33][34][35][36][37]. Encephalopathic psychosis has been particularly described in patients with mitochondrial encephalomyopathy, lactacidosis, and stroke-like episodes (MELAS) syndrome [38][39][40][41][42].…”

Section: Clinical Presentationmentioning

confidence: 99%

Cognitive decline as a manifestation of mitochondrial disorders (mitochondrial dementia)

Finsterer

2008

Journal of the Neurological Sciences

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Persistent organic personality change as rare psychiatric manifestation of MELAS syndrome

Cited by 12 publications

References 9 publications

Is a "Mitochondrial Psychiatry" in the Future? A Review

Is a "Mitochondrial Psychiatry" in the Future? A Review

Mitochondrial disorders, cognitive impairment and dementia

Cognitive decline as a manifestation of mitochondrial disorders (mitochondrial dementia)

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