Persistent Nonalcoholic Fatty Liver Disease Increases Risk for Carotid Atherosclerosis

Sinn, Dong Hyun; Cho, Soo-Jin; Gu, Seonhye; Seong, Donghyeong; Kang, Danbee; Kim, Hyun-Kyoung; Yi, Boram; Paik, Seung Woon; Güallar, Eliseo; Cho, Juhee; Gwak, Geum Youn

doi:10.1053/j.gastro.2016.06.001

Cited by 101 publications

(73 citation statements)

References 37 publications

(20 reference statements)

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“…NAFLD may accelerate atherosclerosis through increased levels of atherogenic, triglyceride-rich, cholesterol-rich particles and small dense LDL particles 36. Finally, improvement of NAFLD has been associated with reduced progression of carotid intima-media thickness,37 whereas persistent NAFLD was associated with an increased risk of subclinical carotid atherosclerosis development 38. These mechanisms further support the case that NAFLD is not just an epiphenomenon, but an active mediator directly contributing to the progression of atherosclerosis.…”

Section: Discussionmentioning

confidence: 81%

Non-alcoholic fatty liver disease and progression of coronary artery calcium score: a retrospective cohort study

Sinn

Kang

Chang

et al. 2016

Gut

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138

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Section: Discussionmentioning

confidence: 81%

Non-alcoholic fatty liver disease and progression of coronary artery calcium score: a retrospective cohort study

Sinn

Kang

Chang

et al. 2016

Gut

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138

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“…Recent retrospective cohort studies reported a significant association between ultrasound-diagnosed NAFLD and the progression of subclinical coronary or carotid atherosclerosis independent of multiple CVD risk factors. The risk of subclinical carotid/coronary atherosclerosis progression was also higher among patients with NAFLD with increased non-invasive markers of advanced fibrosis at baseline (NAFLD fibrosis score (NFS), fibrosis-4 score or elevated γ-glutamyl transferase levels) 53 54. Additionally, the regression of NAFLD on ultrasound over time was associated with a decreased risk of subclinical carotid atherosclerosis development 53…”

Section: Epidemiological Data Linking Nafld To Risk Of Cvdmentioning

confidence: 99%

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

Adams

Anstee

Tilg

et al. 2017

Gut

888

708

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Key physiological functions of the liver, including glucose and lipid metabolism, become disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated with a systemic inflammatory '' initiated in part by liver-secreted cytokines and molecules. Consequently, the pathophysiological effects of NAFLD extend beyond the liver with a large body of clinical evidence demonstrating NAFLD to be independently associated with both prevalent and incident cardiovascular disease (CVD), chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). The magnitude of risk of developing these extrahepatic diseases parallels the underlying severity of NAFLD, such that patients with non-alcoholic steatohepatitis (NASH) appear to be at greater risk of incident CVD, CKD and T2DM than those with simple steatosis. Other modifiers of risk may include genetic variants (eg, patatin-like phospholipase domain-containing 3 and trans-membrane 6 superfamily member 2 polymorphisms), visceral adipose tissue accumulation, dietary intake and the gut microbiome. Emerging data also suggest that NAFLD may be a risk factor for colonic neoplasia and reduced bone mineral density, especially among men. Importantly, improvement/resolution of NAFLD is associated with a reduced incidence of T2DM and improved kidney function, adding weight to causality and suggesting liver focused treatments may reduce risk of extrahepatic complications. Awareness of these associations is important for the clinicians such that CVD risk factor management, screening for T2DM and CKD are part of the routine management of patients with NAFLD.

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“…The development of NAFLD is linked to elevated BMI, central obesity, and the cardiometabolic syndrome (2,3). Moreover, NAFLD may be a predictor for the development of diabetes mellitus and is an independent risk factor for cardiovascular disease (4,5). Although NAFLD is connected to metabolic derangements associated with obesity, the pathways that link NAFLD, obesity, and cardiometabolic disease are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis

Kimberly¹,

O’Sullivan²,

Nath³

et al. 2017

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Persistent Nonalcoholic Fatty Liver Disease Increases Risk for Carotid Atherosclerosis

Cited by 101 publications

References 37 publications

Non-alcoholic fatty liver disease and progression of coronary artery calcium score: a retrospective cohort study

Non-alcoholic fatty liver disease and progression of coronary artery calcium score: a retrospective cohort study

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis

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